Search Results - "Keek, Simon"

A review on radiomics and the future of theranostics for patient selection in precision medicine by Keek, Simon A, Leijenaar, Ralph Th, Jochems, Arthur, Woodruff, Henry C

“…The growing complexity and volume of clinical data and the associated decision-making processes in oncology promote the advent of precision medicine. Precision…”
Get full text

Automated detection and segmentation of non-small cell lung cancer computed tomography images by Primakov, Sergey P., Ibrahim, Abdalla, van Timmeren, Janita E., Wu, Guangyao, Keek, Simon A., Beuque, Manon, Granzier, Renée W. Y., Lavrova, Elizaveta, Scrivener, Madeleine, Sanduleanu, Sebastian, Kayan, Esma, Halilaj, Iva, Lenaers, Anouk, Wu, Jianlin, Monshouwer, René, Geets, Xavier, Gietema, Hester A., Hendriks, Lizza E. L., Morin, Olivier, Jochems, Arthur, Woodruff, Henry C., Lambin, Philippe

“…Detection and segmentation of abnormalities on medical images is highly important for patient management including diagnosis, radiotherapy, response…”
Get full text

Radiomics: from qualitative to quantitative imaging by Rogers, William, Thulasi Seetha, Sithin, Refaee, Turkey A G, Lieverse, Relinde I Y, Granzier, Renée W Y, Ibrahim, Abdalla, Keek, Simon A, Sanduleanu, Sebastian, Primakov, Sergey P, Beuque, Manon P L, Marcus, Damiënne, van der Wiel, Alexander M A, Zerka, Fadila, Oberije, Cary J G, van Timmeren, Janita E, Woodruff, Henry C, Lambin, Philippe

“…Historically, medical imaging has been a qualitative or semi-quantitative modality. It is difficult to quantify what can be seen in an image, and to turn it…”
Get full text

Privacy-preserving distributed learning of radiomics to predict overall survival and HPV status in head and neck cancer by Bogowicz, Marta, Jochems, Arthur, Deist, Timo M., Tanadini-Lang, Stephanie, Huang, Shao Hui, Chan, Biu, Waldron, John N., Bratman, Scott, O’Sullivan, Brian, Riesterer, Oliver, Studer, Gabriela, Unkelbach, Jan, Barakat, Samir, Brakenhoff, Ruud H., Nauta, Irene, Gazzani, Silvia E., Calareso, Giuseppina, Scheckenbach, Kathrin, Hoebers, Frank, Wesseling, Frederik W. R., Keek, Simon, Sanduleanu, Sebastian, Leijenaar, Ralph T. H., Vergeer, Marije R., Leemans, C. René, Terhaard, Chris H. J., van den Brekel, Michiel W. M., Hamming-Vrieze, Olga, van der Heijden, Martijn A., Elhalawani, Hesham M., Fuller, Clifton D., Guckenberger, Matthias, Lambin, Philippe

“…A major challenge in radiomics is assembling data from multiple centers. Sharing data between hospitals is restricted by legal and ethical regulations…”
Get full text

Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy by Keek, Simon, Sanduleanu, Sebastian, Wesseling, Frederik, de Roest, Reinout, van den Brekel, Michiel, van der Heijden, Martijn, Vens, Conchita, Giuseppina, Calareso, Licitra, Lisa, Scheckenbach, Kathrin, Vergeer, Marije, Leemans, C René, Brakenhoff, Ruud H, Nauta, Irene, Cavalieri, Stefano, Woodruff, Henry C, Poli, Tito, Leijenaar, Ralph, Hoebers, Frank, Lambin, Philippe

“…In this study, we investigate the role of radiomics for prediction of overall survival (OS), locoregional recurrence (LRR) and distant metastases (DM) in stage…”
Get full text

A clinically relevant computed tomography (CT) radiomics strategy for intracranial rodent brain tumour monitoring by Connor, Kate, Conroy, Emer, White, Kieron, Shiels, Liam P., Keek, Simon, Ibrahim, Abdalla, Gallagher, William M., Sweeney, Kieron J., Clerkin, James, O’Brien, David, Cryan, Jane B., O’Halloran, Philip J., Heffernan, Josephine, Brett, Francesca, Lambin, Philippe, Woodruff, Henry C., Byrne, Annette T.

“…Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted…”
Get full text

Predicting Adverse Radiation Effects in Brain Tumors After Stereotactic Radiotherapy With Deep Learning and Handcrafted Radiomics by Keek, Simon A., Beuque, Manon, Primakov, Sergey, Woodruff, Henry C., Chatterjee, Avishek, van Timmeren, Janita E., Vallières, Martin, Hendriks, Lizza E. L., Kraft, Johannes, Andratschke, Nicolaus, Braunstein, Steve E., Morin, Olivier, Lambin, Philippe

“…Introduction There is a cumulative risk of 20–40% of developing brain metastases (BM) in solid cancers. Stereotactic radiotherapy (SRT) enables the application…”
Get full text

Correction: Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy by Keek, Simon, Sanduleanu, Sebastian, Wesseling, Frederik, Reinout de Roest, Michiel van den Brekel, van der Heijden, Martijn, Vens, Conchita, Giuseppina, Calareso, Licitra, Lisa, Scheckenbach, Kathrin, Vergeer, Marije, Leemans, C. René, Brakenhoff, Ruud H., Nauta, Irene, Cavalieri, Stefano, Woodruff, Henry C., Poli, Tito, Leijenaar, Ralph, Hoebers, Frank, Lambin, Philippe

“…[This corrects the article DOI: 10.1371/journal.pone.0232639.]…”
Get full text

A Prospectively Validated Prognostic Model for Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck Based on Radiomics of Computed Tomography Images by Keek, Simon A., Wesseling, Frederik W. R., Woodruff, Henry C., van Timmeren, Janita E., Nauta, Irene H., Hoffmann, Thomas K., Cavalieri, Stefano, Calareso, Giuseppina, Primakov, Sergey, Leijenaar, Ralph T. H., Licitra, Lisa, Ravanelli, Marco, Scheckenbach, Kathrin, Poli, Tito, Lanfranco, Davide, Vergeer, Marije R., Leemans, C. René, Brakenhoff, Ruud H., Hoebers, Frank J. P., Lambin, Philippe

“…Background: Locoregionally advanced head and neck squamous cell carcinoma (HNSCC) patients have high relapse and mortality rates. Imaging-based decision…”
Get full text

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models by O’Farrell, Alice C., Jarzabek, Monika A., Lindner, Andreas U., Carberry, Steven, Conroy, Emer, Miller, Ian S., Connor, Kate, Shiels, Liam, Zanella, Eugenia R., Lucantoni, Federico, Lafferty, Adam, White, Kieron, Meyer Villamandos, Mariangela, Dicker, Patrick, Gallagher, William M., Keek, Simon A., Sanduleanu, Sebastian, Lambin, Philippe, Woodruff, Henry C., Bertotti, Andrea, Trusolino, Livio, Byrne, Annette T., Prehn, Jochen H. M.

“…Resistance to chemotherapy often results from dysfunctional apoptosis, however multiple proteins with overlapping functions regulate this pathway. We sought to…”
Get full text

Investigation of the added value of CT-based radiomics in predicting the development of brain metastases in patients with radically treated stage III NSCLC by Keek, Simon A., Kayan, Esma, Chatterjee, Avishek, Belderbos, José S. A., Bootsma, Gerben, van den Borne, Ben, Dingemans, Anne-Marie C., Gietema, Hester A., Groen, Harry J. M., Herder, Judith, Pitz, Cordula, Praag, John, De Ruysscher, Dirk, Schoenmaekers, Janna, Smit, Hans J. M., Stigt, Jos, Westenend, Marcel, Zeng, Haiyan, Woodruff, Henry C., Lambin, Philippe, Hendriks, Lizza

“…Introduction: Despite radical intent therapy for patients with stage III non-small-cell lung cancer (NSCLC), cumulative incidence of brain metastases (BM)…”
Get full text

865: Clinical evaluation of organs at risk deep learning auto-segmentation for cervix brachytherapy by Keek, Simon A., Mans, Anton, Nowee, Marlies E., Rijkmans, Eva E., Schaake, Eva C., Simões, Rita, Janssen, Tomas M.

Get full text

Radiomics Analysis for Clinical Decision Support in Nuclear Medicine by Ibrahim, Abdalla, Vallières, Martin, Woodruff, Henry, Primakov, Sergey, Beheshti, Mohsen, Keek, Simon, Refaee, Turkey, Sanduleanu, Sebastian, Walsh, Sean, Morin, Olivier, Lambin, Philippe, Hustinx, Roland, Mottaghy, Felix M.

“…Radiomics – the high-throughput computation of quantitative image features extracted from medical imaging modalities- can be used to aid clinical decision…”
Get full text

MODL-24. ESTABLISHING A CLINICALLY RELEVANT CT AND ASSOCIATED RADIOMICS PIPELINE FOR INTRACRANIAL RODENT TUMOUR MODELS by Connor, Kate, Conroy, Emer, White, Kieron, Shiels, Liam, Keek, Simon, Ibrahim, Abdalla, Gallagher, William, Clerkin, James, Sweeney, Kieron, O'Brien, David, Cryan, Jane, Heffernan, Josephine, Brett, Francesca, Lambin, Philippe, Woodruff, Henry, Byrne, Annette

“…Abstract While magnetic resonance imaging (MRI) is the predominant imaging modality for glioblastoma (GBM), pre-clinical MRI scanner availability is limited…”
Get full text

EXTH-30. EXPANDING THE UTILITY OF PRE-CLINICAL CONTRAST ENHANCED CT (CE-CT) FOR TUMOR DETECTION IN ORTHOTOPIC GBM MODELS USING RADIOMICS by Connor, Kate, Conroy, Emer, White, Kieron, Shiels, Liam, Gallagher, William, Keek, Simon, Ibrahim, Abdalla, Clerkin, James, O’Brien, David, Lambin, Philippe, Woodruff, Henry, Byrne, Annette

“…Abstract Despite magnetic resonance imaging (MRI) being the gold-standard imaging modality in the glioblastoma (GBM) setting, the availability of rodent MRI…”
Get full text

Development of a multiomics database for personalized prognostic forecasting in head and neck cancer: The Big Data to Decide EU Project by Cavalieri, Stefano, De Cecco, Loris, Brakenhoff, Ruud H., Serafini, Mara Serena, Canevari, Silvana, Rossi, Silvia, Lanfranco, Davide, Hoebers, Frank J. P., Wesseling, Frederik W. R., Keek, Simon, Scheckenbach, Kathrin, Mattavelli, Davide, Hoffmann, Thomas, López Pérez, Laura, Fico, Giuseppe, Bologna, Marco, Nauta, Irene, Leemans, C. René, Trama, Annalisa, Klausch, Thomas, Berkhof, Johannes Hans, Tountopoulos, Vasilis, Shefi, Ron, Mainardi, Luca, Mercalli, Franco, Poli, Tito, Licitra, Lisa

“…Background Despite advances in treatments, 30% to 50% of stage III‐IV head and neck squamous cell carcinoma (HNSCC) patients relapse within 2 years after…”
Get full text

Correction: Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma by Keek, Simon, Sanduleanu, Sebastian, Wesseling, Frederik, Reinout de Roest, Michiel van den Brekel, van der Heijden, Martijn, Vens, Conchita, Giuseppina, Calareso, Licitra, Lisa, Scheckenbach, Kathrin, Vergeer, Marije, Leemans, C. René, Brakenhoff, Ruud H, Nauta, Irene, Cavalieri, Stefano, Woodruff, Henry C, Poli, Tito, Leijenaar, Ralph, Hoebers, Frank, Lambin, Philippe

Get full text

Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma by Keek, Simon, Sanduleanu, Sebastian, Wesseling, Frederik, de Roest, Reinout, van den Brekel, Michiel, van der Heijden, Martijn, Vens, Conchita, Giuseppina, Calareso, Licitra, Lisa, Scheckenbach, Kathrin, Vergeer, Marije, Leemans, C. René, Brakenhoff, Ruud H, Nauta, Irene, Cavalieri, Stefano, Woodruff, Henry C, Poli, Tito, Leijenaar, Ralph, Hoebers, Frank, Lambin, Philippe, Hsieh, Jason Chia-Hsun

“…Introduction In this study, we investigate the role of radiomics for prediction of overall survival (OS), locoregional recurrence (LRR) and distant metastases…”
Get full text