Search Results - "Keegan, Mackenzie"
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Longitudinal comparison of the self‐entry Amyotrophic Lateral Sclerosis Functional Rating Scale‐Revised (ALSFRS‐RSE) and Rasch‐Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) as outcome measures in people with amyotrophic lateral sclerosis
Published in Muscle & nerve (01-10-2022)“…Introduction/aims Improved functional outcome measures in amyotrophic lateral sclerosis (ALS) would aid ALS trial design and help hasten drug discovery. We…”
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Journal Article -
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A novel digital tool for detection and monitoring of amyotrophic lateral sclerosis motor impairment and progression via keystroke dynamics
Published in Scientific reports (22-07-2024)“…Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition leading to progressive muscle weakness, atrophy, and ultimately death…”
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Journal Article -
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Multicenter expanded access program for access to investigational products for amyotrophic lateral sclerosis
Published in Muscle & nerve (01-08-2024)“…Introduction/Aims Expanded access (EA) is a Food and Drug Administration‐regulated pathway to provide access to investigational products (IPs) to individuals…”
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Journal Article -
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Speech motor impairment in ALS is associated with multiregional cortical thinning beyond primary motor cortex
Published in Frontiers in neurology (01-10-2024)“…Cortical thinning is well-documented in individuals with amyotrophic lateral sclerosis (ALS), yet its association with speech deterioration remains…”
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Selective atrophy of the cervical enlargement in whole spinal cord MRI of amyotrophic lateral sclerosis
Published in NeuroImage clinical (01-01-2022)“…•Participants with ALS exhibited atrophy of the cervical enlargement in the spinal cord.•We did not observe similar evidence of atrophy of the thoracolumbar…”
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Journal Article -
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Using Smartphones to Reduce Research Burden in a Neurodegenerative Population and Assessing Participant Adherence: A Randomized Clinical Trial and Two Observational Studies
Published in JMIR mHealth and uHealth (04-02-2022)“…Smartphone studies provide an opportunity to collect frequent data at a low burden on participants. Therefore, smartphones may enable data collection from…”
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Journal Article -
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Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish
Published in Science (American Association for the Advancement of Science) (15-05-2020)“…The establishment of reproductive barriers between populations can fuel the evolution of new species. A genetic framework for this process posits that…”
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Journal Article -
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The Genetic Architecture of Variation in the Sexually Selected Sword Ornament and Its Evolution in Hybrid Populations
Published in Current biology (08-03-2021)“…Biologists since Darwin have been fascinated by the evolution of sexually selected ornaments, particularly those that reduce viability. Uncovering the genetic…”
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Journal Article -
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Longitudinal comparison of the self-administered ALSFRS-RSE and ALSFRS-R as functional outcome measures in ALS
Published in Amyotrophic lateral sclerosis and frontotemporal degeneration (01-08-2024)“…Test the feasibility, adherence rates and optimal frequency of digital, remote assessments using the ALSFRS-RSE via a customized smartphone-based app. This…”
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Journal Article -
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“Tsuchigumo no sōshi”: The tale of the mountain spider
Published 01-01-2009“…The early-medieval work of Japanese fiction titled Tsuchigumo no sōshi tells the fantastic story of the Heian period courtier Minamoto no Raikō and his…”
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Dissertation -
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"Tsuchigumo no soshi": The tale of the mountain spider
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Dissertation