Search Results - "Keegan, E"

A Primer on Bayesian Inference for Biophysical Systems by Hines, Keegan E.

“…Bayesian inference is a powerful statistical paradigm that has gained popularity in many fields of science, but adoption has been somewhat slower in…”
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Determination of parameter identifiability in nonlinear biophysical models: A Bayesian approach by Hines, Keegan E, Middendorf, Thomas R, Aldrich, Richard W

“…A major goal of biophysics is to understand the physical mechanisms of biological molecules and systems. Mechanistic models are evaluated based on their…”
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Inferring subunit stoichiometry from single molecule photobleaching by Hines, Keegan E

“…Single molecule photobleaching is a powerful tool for determining the stoichiometry of protein complexes. By attaching fluorophores to proteins of interest,…”
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Insights into DNA-binding motifs and mechanisms of Francisella tularensis novicida two-component system response regulator proteins QseB, KdpE, and BfpR by Gaddy, Keegan E., Bensch, Elody M., Cavanagh, John, Milton, Morgan E.

“…Two component system bacterial response regulators are typically DNA-binding proteins which enable the genetic regulation of many adaptive bacterial behaviors…”
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Analyzing Single-Molecule Time Series via Nonparametric Bayesian Inference by Hines, Keegan E., Bankston, John R., Aldrich, Richard W.

“…The ability to measure the properties of proteins at the single-molecule level offers an unparalleled glimpse into biological systems at the molecular scale…”
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Nasal Epithelial Cell-Based Models for Individualized Study in Cystic Fibrosis by Keegan, Duncan E, Brewington, John J

“…The emergence of highly effective CFTR modulator therapy has led to significant improvements in health care for most patients with cystic fibrosis (CF). For…”
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Winter Rye Cover Crop Impacts on Runoff Water Quality in a Northern New York (USA) Tile-Drained Maize Agroecosystem by Griffith, Keegan E., Young, Eric O., Klaiber, Laura B., Kramer, Stephen R.

“…Nonpoint source phosphorus (P) and nitrogen (N) pollution from agriculture is a global concern. Planting a cover crop after harvesting annual crops such as…”
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Becoming a birth mother in the context of a planned same-sex family: 'As amazing as it is, it's kind of a tough road to navigate' by Keegan, Mary E., Nixon, Elizabeth, Creaner, Mary

“…This qualitative study explored how ten birth mothers in same-sex relationships in Ireland experienced becoming a mother. Semi-structured, face-to-face…”
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Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability by Vallianatos, Christina N, Farrehi, Clara, Friez, Michael J, Burmeister, Margit, Keegan, Catherine E, Iwase, Shigeki

“…Intellectual disability (ID) affects up to 2% of the population world-wide and often coincides with other neurological conditions such as autism spectrum…”
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Periurethral injection therapy for urinary incontinence in women by Keegan, P E, Atiemo, K, Cody, J, McClinton, S, Pickard, R

“…Periurethral or transurethral injection of bulking agents is a surgical procedure most often used for the treatment of stress urinary incontinence a common,…”
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Genotype–phenotype analysis of 523 patients by genetics evaluation and clinical exome sequencing by Ziats, Mark N., Ahmad, Ayesha, Bernat, John A., Fisher, Rachel, Glassford, Megan, Hannibal, Mark C., Jacher, Joseph E., Weiser, Natasha, Keegan, Catherine E., Lee, Kristen N., Marzulla, Tessa B., O’Connor, Bridget C., Quinonez, Shane C., Seemann, Lauren, Turner, Lauren, Bielas, Stephanie, Harris, Nicholas L., Ogle, Jacob D., Innis, Jeffrey W., Martin, Donna M.

“…Background As clinical exome sequencing (CES) becomes more common, understanding which patients are most likely to benefit and in what manner is critical for…”
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MAP3K1‐related gonadal dysgenesis: Six new cases and review of the literature by Granados, Andrea, Alaniz, Veronica I., Mohnach, Lauren, Barseghyan, Hayk, Vilain, Eric, Ostrer, Harry, Quint, Elisabeth H., Chen, Ming, Keegan, Catherine E.

“…Investigation of disorders of sex development (DSD) has resulted in the discovery of multiple sex‐determining genes. MAP3K1 encodes a signal transduction…”
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Telomere Protection by TPP1 Is Mediated by POT1a and POT1b by Kibe, Tatsuya, Osawa, Gail A., Keegan, Catherine E., de Lange, Titia

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Connexin 43 (GJA1) Mutations Cause the Pleiotropic Phenotype of Oculodentodigital Dysplasia by Paznekas, William A., Boyadjiev, Simeon A., Shapiro, Robert E., Daniels, Otto, Wollnik, Bernd, Keegan, Catherine E., Innis, Jeffrey W., Dinulos, Mary Beth, Christian, Cathy, Hannibal, Mark C., Jabs, Ethylin Wang

“…Gap junctions are assemblies of intercellular channels that regulate a variety of physiologic and developmental processes through the exchange of small ions…”
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Genetics of Bladder-Exstrophy-Epispadias Complex (BEEC): Systematic Elucidation of Mendelian and Multifactorial Phenotypes by Reutter, Heiko, Keppler-Noreuil, Kim, E Keegan, Catherine, Thiele, Holger, Yamada, Gen, Ludwig, Michael

“…The Bladder-Exstrophy-Epispadias Complex (BEEC) represents the severe end of the urorectal malformation spectrum, and has a profound impact on continence, and…”
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Trauma as a Public Health Moment: Addressing Vaccine Uptake in Trauma Patients by Keegan, Grace E, Alexander, Rachel, Ogunnowo, Simi, Brown, Isaiah, Zakrison, Tanya L, Hoefer, Lea E

“…Our objective was to identify factors associated with COVID-19 vaccination in trauma patients and to provide an opportunity for patients to engage in…”
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Unexpected ethical dilemmas in sex assignment in 46,XY DSD due to 5‐alpha reductase type 2 deficiency by Byers, Heather M., Mohnach, Lauren H., Fechner, Patricia Y., Chen, Ming, Thomas, Inas H., Ramsdell, Linda A., Shnorhavorian, Margarett, McCauley, Elizabeth A., Amies Oelschlager, Anne‐Marie E., Park, John M., Sandberg, David E., Adam, Margaret P., Keegan, Catherine E.

“…Sex assignment at birth remains one of the most clinically challenging and controversial topics in 46,XY disorders of sexual development (DSD). This is…”
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TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis by Grill, Sherilyn, Padmanaban, Shilpa, Friedman, Ann, Perkey, Eric, Allen, Frederick, Tesmer, Valerie M, Chase, Jennifer, Khoriaty, Rami, Keegan, Catherine E, Maillard, Ivan, Nandakumar, Jayakrishnan

“…Telomerase catalyzes chromosome end replication in stem cells and other long-lived cells. Mutations in telomerase or telomere-related genes result in diseases…”
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Next-generation sequencing identifies the Danforth's short tail mouse mutation as a retrotransposon insertion affecting Ptf1a expression by Vlangos, Christopher N, Siuniak, Amanda N, Robinson, Dan, Chinnaiyan, Arul M, Lyons, Jr, Robert H, Cavalcoli, James D, Keegan, Catherine E

“…The semidominant Danforth's short tail (Sd) mutation arose spontaneously in the 1920s. The homozygous Sd phenotype includes severe malformations of the axial…”
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Identification of critical regions for clinical features of distal 10q deletion syndrome by Yatsenko, SA, Kruer, MC, Bader, PI, Corzo, D, Schuette, J, Keegan, CE, Nowakowska, B, Peacock, S, Cai, WW, Peiffer, DA, Gunderson, KL, Ou, Z, Chinault, AC, Cheung, SW

“…Array comparative genomic hybridization studies were performed to further characterize cytogenetic abnormalities found originally by karyotype and fluorescence…”
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