Search Results - "Keegan, Alissa"

Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC by Keegan, Alissa, Ricciuti, Biagio, Garden, Padric, Cohen, Limor, Nishihara, Reiko, Adeni, Anika, Paweletz, Cloud, Supplee, Julianna, Jänne, Pasi A, Severgnini, Mariano, Awad, Mark M, Walt, David R

“…BackgroundBlood-based biomarkers of anti-solid tumor immune checkpoint blockade (ICB) response are lacking. We hypothesized that changes in systemic cytokine…”
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A phase I study of the safety and efficacy of talimogene laherparepvec in Japanese patients with advanced melanoma by Yamazaki, Naoya, Isei, Taiki, Kiyohara, Yoshio, Koga, Hiroshi, Kojima, Takashi, Takenouchi, Tatsuya, Yokota, Kenji, Namikawa, Kenjiro, Yi, Min, Keegan, Alissa, Fukushima, Satoshi

“…Talimogene laherparepvec (T‐VEC) is approved for the treatment of unresectable melanoma in the USA, Europe, and Australia. This phase I, multicenter,…”
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Impact of clinical sample handling and processing on ultra-low level measurements of plasma cytokines by Cohen, Limor, Keegan, Alissa, Melanson, Stacy E.F., Walt, David R.

“…In this study, we evaluated the impact of clinical sample handling and processing on IL-6, IL-10, IFNγ, and IL-2 measurements in plasma. We collected whole…”
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Real World Assessment of Treatment Patterns and Outcomes Among Multiple Myeloma Patients across Different Risk Stratification Criteria in the United States: A Retrospective Cohort Study by Rahman, Motiur, Kim, Christopher, Mateus, Jazmine, Keegan, Alissa

“…Background: Despite the development of highly active novel agents, high risk (HR) multiple myeloma (MM) patients continue to demonstrate relatively poor…”
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Real-world assessment of the treatment patterns and outcomes among patients with multiple myeloma across different risk stratification criteria in the United States: a retrospective cohort study by Rahman, Motiur, Keegan, Alissa, Mateus, Jazmine, Kim, Christopher

“…This study evaluated prognostic performance of International Staging System (ISS), revised ISS, and chromosomal abnormalities (CA) in newly diagnosed multiple…”
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High-Throughput Screening of a Luciferase Reporter of Gene Silencing on the Inactive X Chromosome by Keegan, Alissa, Plath, Kathrin, Damoiseaux, Robert

“…Assays of luciferase gene activity are a sensitive and quantitative reporter system suited to high-throughput screening. We adapted a luciferase assay to a…”
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Trial in progress: Phase 1b/3 study of bemarituzumab + mFOLFOX6 + nivolumab versus mFOLFOX6 + nivolumab in previously untreated advanced gastric and gastroesophageal junction (GEJ) cancer with FGFR2b overexpression (FORTITUDE-102) by Wainberg, Zev A., Van Cutsem, Eric, Moehler, Markus H., Kang, Yoon-Koo, Yen, Priscilla, Finger, Elizabeth, Keegan, Alissa, Shitara, Kohei

“…TPS4165 Background: Fibroblast growth factor receptor 2b (FGFR2b) is overexpressed in approximately 30% of non-human epidermal growth factor receptor 2…”
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A phase 1/2, open-label, multicenter, dose escalation and cohort expansion study of the safety and efficacy of anti-CD70 allogeneic CRISPR-Cas9–engineered T cells (CTX131) in adult patients with relapsed or refractory solid tumors by Pal, Sumanta Kumar, Reimers, Melissa Andrea, Garmezy, Benjamin, Xu, Wenxin, Hoimes, Christopher J., Weinstein, Michael, Cullingford, Erika L, Ma, Anna, Williams, Leah M, Dar, Henia, Keegan, Alissa, Srour, Samer Ali

“…TPS2676 Background: CD70, a type II transmembrane protein and member of the tumor necrosis factor (TNF) receptor family, demonstrates high expression across…”
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An Overview of Characteristics of Clinical Next-Generation Sequencing-Based Testing for Hematologic Malignancies by Zhang, Bing M, Keegan, Alissa, Li, Peng, Lindeman, Neal I, Nagarajan, Rakesh, Routbort, Mark J, Vasalos, Patricia, Kim, Annette S, Merker, Jason D

“…With the increasing integration of molecular alterations into the evaluation of hematologic malignancies (HM), somatic mutation profiling by next-generation…”
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Proficiency Testing of Standardized Samples Shows High Interlaboratory Agreement for Clinical Next Generation Sequencing-Based Hematologic Malignancy Assays With Survey Material-Specific Differences in Variant Frequencies by Keegan, Alissa, Bridge, Julia A, Lindeman, Neal I, Long, Thomas A, Merker, Jason D, Moncur, Joel T, Montgomery, Nathan D, Nagarajan, Rakesh, Rothberg, Paul G, Routbort, Mark J, Vasalos, Patricia, Xian, Rena, Kim, Annette S

“…As laboratories increasingly turn from single-analyte testing in hematologic malignancies to next-generation sequencing-based panel testing, there is a…”
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Abstract CT002: CTX130 allogeneic CRISPR-Cas9-engineered chimeric antigen receptor (CAR) T cells in patients with advanced clear cell renal cell carcinoma: Long-term follow-up and translational data from the phase 1 COBALT-RCC study by Pal, Sumanta Kumar, Tran, Ben, Haanen, John B., Hurwitz, Michael, Sacher, Adrian, Agarwal, Neeraj, Tannir, Nizar, Budde, Elizabeth, Harrison, Simon, Klobuch, Sebastian, Patel, Sagar S., Dequeant, Mary-Lee, He, Qiuling Ally, Keegan, Alissa, Dar, Henia, Ma, Anna, Morrow, PK, Srour, Samer A.

“…Abstract Background: The mainstay of therapy for clear cell renal cell carcinoma (ccRCC), the most prevalent subtype of kidney cancer, includes checkpoint…”
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Development of a Commercial Reference Laboratory Elective Rotation for Residents in Clinical Pathology by Lewandrowski, Kent, Keegan, Alissa, Makarenko, Vladislav, Maryamchak, Elena, Mata, Douglas A, Palte, Michael J, Rudolf, Joseph W, Safdar, Nida, Schmidt, Ryan J, Stuart, Lena, Xiong, Yiqin, Rao, Lokinendi, Melanson, Stacy E F, Michael Snyder, L

“…Abstract Objectives To develop a curriculum for a commercial reference laboratory clinical pathology training elective. Methods A 4-day elective at Quest…”
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31. The PT alphabet soup: LDT, FDA, NGS, non-NGS, @#$! by Kim, Annette S., Bartley, Angela N., Bridge, Julia A., Devereaux, Kelly, Iafrate, A. John, Jennings, Lawrence, Kamel-Reid, Suzanne, Keegan, Alissa, Lazar, Alexander J., Lindeman, Neal I., Long, Thomas A., Merker, Jason D., Moncur, Joel T., Montgomery, Nathan, Montgomery, Stephen B., Nagarajan, Rakesh, Oakley, Fredrick D., Portier, Bryce P., Rai, Alex J., Rimm, David L., Rothberg, Paul G., Smail, Craig, Surrey, Lea F., Vasalos, Patricia, Xian, Rena

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