Search Results - "Keefer, Christopher"

In-Silico Extraction of Design Ideas Using MMPA-by-QSAR and its Application on ADME Endpoints by Koutsoukas, Alexios, Chang, George, Keefer, Christopher E

“…Matched molecular pair analysis (MMPA) has emerged as a powerful approach to mine and extract tacit knowledge from measured databases of small molecules…”
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In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development by Lombardo, Franco, Desai, Prashant V, Arimoto, Rieko, Desino, Kelly E, Fischer, Holger, Keefer, Christopher E, Petersson, Carl, Winiwarter, Susanne, Broccatelli, Fabio

“…In silico tools to investigate absorption, distribution, metabolism, excretion, and pharmacokinetics (ADME-PK) properties of new chemical entities are an…”
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Evaluating the Differences in Cycloalkyl Ether Metabolism Using the Design Parameter “Lipophilic Metabolism Efficiency” (LipMetE) and a Matched Molecular Pairs Analysis by Stepan, Antonia F, Kauffman, Gregory W, Keefer, Christopher E, Verhoest, Patrick R, Edwards, Martin

“…We have observed previously that modification of ring size and substitution pattern may be used as a strategy to mitigate the metabolic instability of…”
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Interpretable, Probability-Based Confidence Metric for Continuous Quantitative Structure–Activity Relationship Models by Keefer, Christopher E, Kauffman, Gregory W, Gupta, Rishi Raj

“…A great deal of research has gone into the development of robust confidence in prediction and applicability domain (AD) measures for quantitative…”
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The Comparison of Machine Learning and Mechanistic In Vitro–In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance by Keefer, Christopher E., Chang, George, Di, Li, Woody, Nathaniel A., Tess, David A., Osgood, Sarah M., Kapinos, Brendon, Racich, Jill, Carlo, Anthony A., Balesano, Amanda, Ferguson, Nicholas, Orozco, Christine, Zueva, Larisa, Luo, Lina

“…Accurate prediction of human pharmacokinetics (PK) remains one of the key objectives of drug metabolism and PK (DMPK) scientists in drug discovery projects…”
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Prediction of Fraction Unbound in Microsomal and Hepatocyte Incubations: A Comparison of Methods across Industry Datasets by Winiwarter, Susanne, Chang, George, Desai, Prashant, Menzel, Karsten, Faller, Bernard, Arimoto, Rieko, Keefer, Christopher, Broccatell, Fabio

“…The fraction unbound in the incubation, f u,inc, is an important parameter to consider in the evaluation of intrinsic clearance measurements performed in vitro…”
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The use of matched molecular series networks for cross target structure activity relationship translation and potency prediction by Keefer, Christopher E, Chang, George

“…Matched molecular series (MMS) analysis is an extension of matched molecular pair (MMP) analysis where all of the MMPs belong to the same chemical series. An…”
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Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors by Jr, James E. Crowe, Tumpey, Terrence M, Altschuler, Eric L, Hicar, Mark D, Keefer, Christopher J, Wilson, Ian A, Aguilar, Patricia V, Pappas, Claudia, Basler, Christopher F, McGraw, Patricia A, Yu, Xiaocong, Martinez, Osvaldo, Tsibane, Tshidi, Perrone, Lucy A, Stevens, James, House, Frances S

“…Investigation of the human antibody response to influenza virus infection has been largely limited to serology, with relatively little analysis at the…”
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Extraction of tacit knowledge from large ADME data sets via pairwise analysis by Keefer, Christopher E., Chang, George, Kauffman, Gregory W.

“…Pharmaceutical companies routinely collect data across multiple projects for common ADME endpoints. Although at the time of collection the data is intended for…”
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Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design by Di, Li, Keefer, Christopher, Scott, Dennis O., Strelevitz, Timothy J., Chang, George, Bi, Yi-An, Lai, Yurong, Duckworth, Jonathon, Fenner, Katherine, Troutman, Matthew D., Obach, R. Scott

“…Metabolic stability of drug candidates are often determined in both liver microsome and hepatocyte assays. Comparison of intrinsic clearance values between the…”
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A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles by Chang, George, Huard, Kim, Kauffman, Gregory W., Stepan, Antonia F., Keefer, Christopher E.

“…[Display omitted] Aromatic rings, ubiquitous in pharmaceutical compounds, are often exchanged with another ring during the optimization process of drug…”
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Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein by Bates, John T, Keefer, Christopher J, Slaughter, James C, Kulp, Daniel W, Schief, William R, Crowe, James E

“…Abstract The role of binding kinetics in determining neutralizing potency for antiviral antibodies is poorly understood. While it is believed that increased…”
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In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development: Miniperspective by Lombardo, Franco, Desai, Prashant V, Arimoto, Rieko, Desino, Kelly E, Fischer, Holger, Keefer, Christopher E, Petersson, Carl, Winiwarter, Susanne, Broccatelli, Fabio

“…In silico tools to investigate absorption, distribution, metabolism, excretion, and pharmacokinetics (ADME-PK) properties of new chemical entities are an…”
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Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency by Bates, John T, Keefer, Christopher J, Utley, Thomas J, Correia, Bruno E, Schief, William R, Crowe, Jr, James E

“…The role of affinity in determining neutralizing potency of mAbs directed against viruses is not well understood. We investigated the kinetic, structural, and…”
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P142 - Evaluation of fraction unbound across five species and seven tissues and the impact of low temperature by Ryu, Sangwoo, Atkinson, Karen, Novak, Jonathan, Burchett, Woodrow, Tess, David, Di, Li, Keefer, Christopher, Chang, George, Steeno, Gregory, Patel, Roshan, Riccardi, Keith

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A Recombinant Human Monoclonal Antibody to Human Metapneumovirus Fusion Protein That Neutralizes Virus In Vitro and Is Effective Therapeutically In Vivo by WILLIAMS, John V, ZHIFENG CHEN, BURTON, Dennis R, CROWE, James E, WILLIAMSON, R. Anthony, CSEKE, Gabriella, WRIGHT, David W, KEEFER, Christopher J, TOLLEFSON, Sharon J, HESSELL, Ann, PODSIAD, Amy, SHEPHERD, Bryan E, PAOLO SANNA, Pietro

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Correction: Corrigendum: Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors by Yu, Xiaocong, Tsibane, Tshidi, McGraw, Patricia A., House, Frances S., Keefer, Christopher J., Hicar, Mark D., Tumpey, Terrence M., Pappas, Claudia, Perrone, Lucy A., Martinez, Osvaldo, Stevens, James, Wilson, Ian A., Aguilar, Patricia V., Altschuler, Eric L., Basler, Christopher F., Crowe, James E.

“…Nature 455, 532–536 (2008); doi:10.1038/nature07231 In this Letter, the heavy-chain sequence of 1F1 was in error and has been corrected in GenBank…”
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Rejecting unclassifiable samples with decision forests by Keefer, Christopher E., Woody, Nathaniel A.

“…Validation of empirical models is designed to produce statistics related to the average error rate of the model. These statistics can be used to minimize…”
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Reovirus-Induced G2/M Cell Cycle Arrest Requires ς1s and Occurs in the Absence of Apoptosis by Poggioli, George J., Keefer, Christopher, Connolly, Jodi L., Dermody, Terence S., Tyler, Kenneth L.

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mitotic Phosphorylation of Bcl-2 during Normal Cell Cycle Progression and Taxol-induced Growth Arrest by Scatena, Caroline D., Stewart, Zoe A., Mays, Deborah, Tang, Luo Jia, Keefer, Christopher J., Leach, Steven D., Pietenpol, Jennifer A.

“…There is increasing evidence that prolonged mitotic arrest initiates apoptosis; however, little is known about the signaling pathways involved. Several studies…”
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