CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis

Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immun...

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Bibliographic Details
Published in:Journal of immune based therapies and vaccines Vol. 8; no. 1; p. 1
Main Authors: Bhagawati-Prasad, Vijay Ns, De Leenheer, Evy, Keefe, Nadine P, Ryan, Lorna A, Carlring, Jennifer, Heath, Andrew W
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 04-02-2010
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Summary:Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A.
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ISSN:1476-8518
1476-8518
DOI:10.1186/1476-8518-8-1