Search Results - "Keefe, David L"

Widespread Transcriptional Scanning in the Testis Modulates Gene Evolution Rates by Xia, Bo, Yan, Yun, Baron, Maayan, Wagner, Florian, Barkley, Dalia, Chiodin, Marta, Kim, Sang Y., Keefe, David L., Alukal, Joseph P., Boeke, Jef D., Yanai, Itai

“…The testis expresses the largest number of genes of any mammalian organ, a finding that has long puzzled molecular biologists. Our single-cell transcriptomic…”
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Resveratrol protects against age-associated infertility in mice by Liu, Mengyuan, Yin, Yu, Ye, Xiaoying, Zeng, Ming, Zhao, Qiang, Keefe, David L., Liu, Lin

“…STUDY QUESTION Does resveratrol counteract age-associated infertility in a mouse model of reproductive aging? SUMMARY ANSWER Long-term-oral administration of…”
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mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy by Goldman, Kara N., Chenette, Devon, Arju, Rezina, Duncan, Francesca E., Keefe, David L., Grifo, Jamie A., Schneider, Robert J.

“…The ovary contains oocytes within immature (primordial) follicles that are fixed in number at birth. Activation of follicles within this fixed pool causes an…”
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Easing US restrictions on mitochondrial replacement therapy would protect research interests but grease the slippery slope by Keefe, David L.

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Physician Referral for Fertility Preservation in Oncology Patients: A National Study of Practice Behaviors by Quinn, Gwendolyn P, Vadaparampil, Susan T, Lee, Ji-Hyun, Jacobsen, Paul B, Bepler, Gerold, Lancaster, Johnathan, Keefe, David L, Albrecht, Terrance L

“…Cancer survival rates are improving, and the focus is moving toward quality survival. Fertility is a key aspect of quality of life for cancer patients of…”
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Rif1 Maintains Telomere Length Homeostasis of ESCs by Mediating Heterochromatin Silencing by Dan, Jiameng, Liu, Yifei, Liu, Na, Chiourea, Maria, Okuka, Maja, Wu, Tao, Ye, Xiaoying, Mou, Chunlin, Wang, Lei, Wang, Lingling, Yin, Yu, Yuan, Jihong, Zuo, Bingfeng, Wang, Fang, Li, Zhiguo, Pan, Xinghua, Yin, Zhinan, Chen, Lingyi, Keefe, David L., Gagos, Sarantis, Xiao, Andrew, Liu, Lin

“…Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of embryonic stem cells (ESCs). We show that telomere-associated…”
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Delay in oocyte aging in mice by the antioxidant N-acetyl-l-cysteine (NAC) by Liu, Jinmiao, Liu, Mengyuan, Ye, Xiaoying, Liu, Kai, Huang, Junjiu, Wang, Lingling, Ji, Guangzhen, Liu, Na, Tang, Xiangdong, Baltz, Jay M., Keefe, David L., Liu, Lin

“…BACKGROUND Ovarian aging is associated with declining numbers and quality of oocytes and follicles. Oxidative stress by reactive oxygen species (ROS)…”
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Molecular Features of Polycystic Ovary Syndrome Revealed by Transcriptome Analysis of Oocytes and Cumulus Cells by Li, Jie, Chen, Haixia, Gou, Mo, Tian, Chenglei, Wang, Huasong, Song, Xueru, Keefe, David L., Bai, Xiaohong, Liu, Lin

“…Polycystic ovary syndrome (PCOS) is typically characterized by a polycystic ovarian morphology, hyperandrogenism, ovulatory dysfunction, and infertility…”
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In every end there is a beginning—telomeres in male reproduction by Keefe, David L., M.D

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Phenotypic continuum between Waardenburg syndrome and idiopathic hypogonadotropic hypogonadism in humans with SOX10 variants by Rojas, Rebecca A., Kutateladze, Anna A., Plummer, Lacey, Stamou, Maria, Keefe, David L., Salnikov, Kathryn B., Delaney, Angela, Hall, Janet E., Sadreyev, Ruslan, Ji, Fei, Fliers, Eric, Gambosova, Katarina, Quinton, Richard, Merino, Paulina M., Mericq, Veronica, Seminara, Stephanie B., Crowley, William F., Balasubramanian, Ravikumar

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Telomeres and reproductive aging by Keefe, David L, Liu, Lin

“…Infertility, miscarriage and aneuploid offspring increase with age in women, and meiotic dysfunction underlies reproductive aging. How aging disrupts meiotic…”
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Association of telomere length with authentic pluripotency of ES/iPS cells by Huang, Junjiu, Wang, Fang, Okuka, Maja, Liu, Na, Ji, Guangzhen, Ye, Xiaoying, Zuo, Bingfeng, Li, Minshu, Liang, Ping, Ge, William W, Tsibris, John CM, Keefe, David L, Liu, Lin

“…Telomerase and telomeres are important for indefinite replication of stem cells. Recently, telomeres of somatic cells were found to be reprogrammed to elongate…”
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Reconstitution of ovarian function following transplantation of primordial germ cells by Zeng, Ming, Sheng, Xiaoyan, Keefe, David L., Liu, Lin

“…Ovarian aging occurs earlier than somatic aging. We tested the hypothesis that ovarian functions could be artificially reconstructed by transplantation of…”
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Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration by Taroc, Ed Zandro M, Naik, Ankana S, Lin, Jennifer M, Peterson, Nicolas B, Keefe, Jr, David L, Genis, Elizabet, Fuchs, Gabriele, Balasubramanian, Ravikumar, Forni, Paolo E

“…During mammalian development, gonadotropin-releasing-hormone-1 neurons (GnRH-1ns) migrate from the developing vomeronasal organ (VNO) into the brain asserting…”
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Robust measurement of telomere length in single cells by Wang, Fang, Pan, Xinghua, Kalmbach, Keri, Seth-Smith, Michelle L, Ye, Xiaoying, Antumes, Danielle M F, Yin, Yu, Liu, Lin, Keefe, David L, Weissman, Sherman M

“…Measurement of telomere length currently requires a large population of cells, which masks telomere length heterogeneity in single cells, or requires FISH in…”
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Zscan4 Contributes to Telomere Maintenance in Telomerase-Deficient Late Generation Mouse ESCs and Human ALT Cancer Cells by Dan, Jiameng, Zhou, Zhongcheng, Wang, Fang, Wang, Hua, Guo, Renpeng, Keefe, David L, Liu, Lin

“…Proper telomere length is essential for indefinite self-renewal of embryonic stem (ES) cells and cancer cells. Telomerase-deficient late generation mouse ES…”
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Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells by Wang, Fang, Yin, Yu, Ye, Xiaoying, Liu, Kai, Zhu, Haiying, Wang, Lingling, Chiourea, Maria, Okuka, Maja, Ji, Guangzhen, Dan, Jiameng, Zuo, Bingfeng, Li, Minshu, Zhang, Qian, Liu, Na, Chen, Lingyi, Pan, Xinghua, Gagos, Sarantis, Keefe, David L, Liu, Lin

“…Rejuvenation of telomeres with various lengths has been found in induced pluripotent stem cells （iPSCs）. Mechanisms of telomere length regulation during…”
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Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome by Pedroso, Daiana Cristina Chielli, M.Sc, Miranda-Furtado, Cristiana Libardi, Ph.D, Kogure, Gislaine Satyko, M.Sc, Meola, Juliana, Ph.D, Okuka, Maja, B.S, Silva, Celso, M.D, Calado, Rodrigo T., M.D., Ph.D, Ferriani, Rui Alberto, M.D., Ph.D, Keefe, David L., M.D., Ph.D, dos Reis, Rosana Maria, M.D., Ph.D

“…Objective To analyze whether leukocyte telomere length (LTL) is impaired in women with polycystic ovary syndrome (PCOS). Design Case–control study. Setting…”
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The telomere theory of reproductive senescence in women by Keefe, David L, Marquard, Kerri, Liu, Lin

“…A unifying theory of reproductive aging, based on telomere shortening, is proposed. Telomere shortening may mediate both 'hits' involved in reproductive aging,…”
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Telomere fusions as a signal of term placental aging? A pilot study by Kohlrausch, Fabiana B, Wang, Fang, Luo, Danxia, Mahn, Rebecca, Keefe, David L

“…The placenta plays an essential role at the beginning of life, nourishing and supporting the fetus, but its life span is limited. In late pregnancy, the…”
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