Search Results - "Keech, E"

A long‐term study of women with normal colposcopy after referral with low‐grade cytological abnormalities by Smith, MCG, Keech, SEJ, Perryman, K, Soutter, WP

“…Background  About 50 000 women are referred annually to colposcopy in England because of a low‐grade smear. About 35% of these women have no colposcopic…”
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Feasibility and acceptability of a decision aid designed for people facing advanced or terminal illness: a pilot randomized trial by Matlock, Dan D., Keech, Tarah A. E., McKenzie, Marlene B., Bronsert, Michael R., Nowels, Carolyn T., Kutner, Jean S.

“…Background  Patients nearing the end of their lives face an array of difficult decisions. Objective  This study was designed to assess the feasibility and…”
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The Design and Synthesis of Potent Inhibitors of Hepatitis C Virus NS3–4A Proteinase by Attwood, MR, Bennett, JM, Campbell, AD, Canning, GGM, Carr, MG, Conway, E, Dunsdon, RM, Greening, JR, Jones, PS, Kay, PB, Handa, BK, Hurst, DN, Jennings, NS, Jordan, S, Keech, E, O'Brien, MA, Overton, HA, King-Underwood, J, Raynham, TM, Stenson, KP, Wilkinson, CS, Wilkinson, TCI, Wilson, FX

“…Hepatitis C virus (HCV) is the cause of the majority of transfusion-associated hepatitis and a significant proportion of community-acquired hepatitis…”
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The design, synthesis and properties of highly potent and selective inhibitors of herpes simplex virus types 1 and 2 thymidine kinase by MARTIN, J. A, THOMAS, G. J, SIMMONITE, H, KAI-IN, P. W, HOLLAND, M, MERRETT, J. H, LAMBERT, R. W, BUSHNELL, D. J, DUNSDON, S. J, FREEMAN, A. C, HOPKINS, R. A, JOHNS, I. R, KEECH, E

“…The rational design and synthesis of nucleotide analogues as inhibitors of herpes simplex virus (HSV) thymidine kinase is described. Starting from thymidine,…”
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THE DEVELOPMENT OF A PREDICTIVE MODEL FOR THE RISK OF REHOSPITALIZATION AMONG HOME CARE PATIENTS by Keech, E K, Short, T

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Potent selective inhibitors of protein kinase C by Davis, Peter D., Hill, Christopher H., Keech, Elizabeth, Lawton, Geoffrey, Nixon, John S., Sedgwick, Anthony D., Wadsworth, Julie, Westmacott, Donald, Wilkinson, Sandra E.

“…A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine…”
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Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity by Davis, Peter D, Elliott, Lucy H, Harris, William, Hill, Christopher H, Hurst, Steven A, Keech, Elizabeth, Kumar, M. K. Hari, Lawton, Geoffrey, Nixon, John S, Wilkinson, Sandra E

“…A hypothetical mode of inhibition of protein kinase C (PKC) by the natural product staurosporine has been used as a basis for the design of substituted…”
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Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction by Bit, Rino A., Davis, Peter D., Elliott, Lucy H., Harris, William, Hill, Christopher H., Keech, Elizabeth, Kumar, Hari, Lawton, Geoffrey, Maw, Anna, Nixon, John S., Vesey, David R., Wadsworth, Julie, Wilkinson, Sandra E.

“…The protein kinase inhibitor staurosporine has been used to design a series of selective bisindolylmaleimide inhibitors of protein kinase C (PKC). Guided by…”
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Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides by Davis, Peter D, Hill, Christopher H, Lawton, Geoffrey, Nixon, John S, Wilkinson, Sandra E, Hurst, Steven A, Keech, Elizabeth, Turner, Susan E

“…The design and synthesis of a series of novel inhibitors of protein kinase C (PKC) is described. These 2,3-bisarylmaleimides were derived from the structural…”
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Nucleoside Analogues as Highly Potent and Selective Inhibitors of Herpes Simplex Virus Thymidine Kinase by Martin, Joseph A, Lambert, Robert W, Merrett, John H, Parkes, Kevin E.B, Thomas, Gareth J, Baker, Stewart J, Bushnell, David J, Cansfield, Julie E, Dunsdon, Stephen J, Freeman, Andrew C, Hopkins, Richard A, Johns, Ian R, Keech, Elizabeth, Simmonite, Heather, Walmsley, Andrea, Wong Kai-In, Philippe, Holland, Mark

“…A series of carboxamide derivatives of 5′-amino-2′,5′-dideoxy-5-ethyluridine has been prepared as inhibitors of HSV-TK (herpes simplex virus thymidine kinase)…”
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Peptide based inhibitors of interleukin-8: structural simplification and enhanced potency by Attwood, Michael R., Conway, Elizabeth A., Dunsdon, Rachel M., Greening, John R., Handa, Balraj K., Jones, Philip S., Jordan, Steven C., Keech, Elizabeth, Wilson, Francis X.

“…Important areas of a lead peptide inhibitor of IL-8 had been previously identified. Chemical modification led to the identification of key amide bonds which…”
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Identification and characterisation of an inhibitor of interleukin-8: a receptor based approach by Attwood, Michael R., Borkakoti, Neera, Bottomley, Gillian A., Conway, Elizabeth A., Cowan, Irene, Fallowfield, Amanda G., Handa, Balraj K., Jones, Philip S., Keech, Elizabeth, Kirtland, Stephen J., Williams, Glyn, Wilson, Francis X.

“…Identification of the extracellular domains of the interleukin-8 (IL-8) receptor led to the synthesis of several peptide sequences. A peptide derived from a…”
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Making Health Care More Accessible to Rural Communities in Waslala, Nicaragua Using Low-Cost Telecommunications by Singh, P., Kulkarni, S., Keech, E., McDermott-Levy, R., Klingler, J.

“…In rural Nicaragua, access to health care professionals and medical facilities is limited. Minimally trained community health workers (CHWs) and understaffed…”
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FMOC solid phase synthesis of an endothelin converting enzyme substrate. Use of allyl ester as the third orthogonal protecting group by Handa, B K, Keech, E

“…The synthesis of a substrate for the endothelin converting enzyme using the continuous flow FMOC solid phase method has been accomplished. The allyl group,…”
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Inhibitors of protein kinase C. II: Substituted bisindolylmaleimides with improved potency and selectivity by DAVIS, P. D, ELLIOTT, L. H, HARRIS, W, HILL, C. H, HURST, S. A, KEECH, E, HARI KUMAR, M. K, LAWTON, G, NIXON, J. S, WILKINSON, S. E

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Synthesis and antiviral activity of metabolites of rimantadine by Manchand, Percy S, Cerruti, Richard L, Martin, Joseph A, Hill, Christopher H, Merrett, John H, Keech, Elizabeth, Belshe, Robert B, Connell, Edward V, Sim, Iain S

“…The hydroxy metabolites of rimantadine (3-5) were synthesized and compared to amantadine (1) and rimantadine (2) for their ability to inhibit the replication…”
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Inhibitors of protein kinase C. III: Potent and highly selective bisindolylmaleimides by conformational restriction by BIT, R. A, DAVIS, P. D, VESEY, D. R, WADSWORTH, J, WILKINSON, S. E, ELLIOTT, L. H, HARRIS, W, HILL, C. H, KEECH, E, HARI KUMAR, LAWTON, G, MAW, A, NIXON, J. S

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Synthesis and antitumomr acitivity of novel 4-demethoxyanthracyclines by ADAMS, N, BLAKE, C, BORADHURST, M. J, BUSHNELL, D. J, HASSALL, C. H, HARTMANN, H. R, KEECH, E, STRATTON, A. R, THOMAS, G. J

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Synthesis and antitumor activity of 9-[(carbamoyloxy)alkyl]anthracyclines a novel class of anthracycline derivatives by Adams, Nigel, Blake, Colin, Broadhurst, Michael J, Bushnell, David J, Hassall, Cedric H, Hartmann, Hans R, Keech, Elizabeth, Stratton, Alan R, Thomas, Gareth J

“…A number of 4-demethoxyanthracyclines having hydroxylalkyl functions at the 9-position have previously been synthesized and shown to have potent antitumor…”
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Synthesis and antitumor activity of novel 4-demethoxyanthracyclines by Adams, Nigel, Blake, Colin, Broadhurst, Michael J, Bushnell, David J, Hassall, Cedric H, Hartmann, Hans R, Keech, Elizabeth, Stratton, Alan R, Thomas, Gareth J

“…A versatile and efficient synthetic route to 4-demethoxyanthracyclinones has been utilized in the preparation of a number of aglycons having 9-alkyl,…”
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