Search Results - "Kee, Seung Jung"
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Protocatechuic acid prevents isoproterenol‐induced heart failure in mice by downregulating kynurenine‐3‐monooxygenase
Published in Journal of cellular and molecular medicine (01-08-2023)“…Protocatechuic acid (3,4‐dihydroxybenzoic acid) prevents oxidative stress, inflammation and cardiac hypertrophy. This study aimed to investigate the…”
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MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA
Published in PloS one (24-03-2021)“…Vascular remodeling and contraction contribute to the development of hypertension. We investigated the role of miR-212-5p and its downstream target in vascular…”
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3
Histone deacetylase inhibitor LMK235 attenuates vascular constriction and aortic remodelling in hypertension
Published in Journal of cellular and molecular medicine (01-04-2019)“…Here, we report that LMK235, a class I and histone deacetylase (HDAC6)‐preferential HDAC inhibitor, reduces hypertension via inhibition of vascular contraction…”
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4
Protocatechuic acid attenuates isoproterenol-induced cardiac hypertrophy via downregulation of ROCK1–Sp1–PKCγ axis
Published in Scientific reports (30-08-2021)“…Cardiac hypertrophy is an adaptive response of the myocardium to pressure overload or adrenergic agonists. Here, we investigated the protective effects and the…”
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Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension
Published in PloS one (04-03-2019)“…Non-selective histone deacetylase (HDAC) inhibitors are known to improve hypertension. Here, we investigated the therapeutic effect and regulatory mechanism of…”
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Under-diagnosis of vector-borne diseases among individuals suspected of having Scrub Typhus in South Korea
Published in PloS one (02-06-2023)“…Due to environmental and ecological changes and suitable habitats, the occurrence of vector-borne diseases is increasing. We investigated the seroprevalence of…”
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Selective HDAC8 Inhibition Attenuates Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis via p38 MAPK Pathway
Published in Frontiers in pharmacology (20-04-2021)“…Histone deacetylase (HDAC) expression and enzymatic activity are dysregulated in cardiovascular diseases. Among Class I HDACs, HDAC2 has been reported to play…”
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Hdac8 Inhibitor Alleviates Transverse Aortic Constriction-Induced Heart Failure in Mice by Downregulating Ace1
Published in Oxidative medicine and cellular longevity (2022)“…Background. Heart failure is characterized by activation of the renin-angiotensin-aldosterone system, which is involved in the regulation of cardiac…”
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Activation and increased production of interleukin‐17 and tumour necrosis factor‐α of mucosal‐associated invariant T cells in patients with periodontitis
Published in Journal of clinical periodontology (01-07-2022)“…Aim Mucosal‐associated invariant T (MAIT) cells are known to be resident in oral mucosal tissue, but their roles in periodontitis are unknown. This study aimed…”
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Xpert MTB/RIF Assay as a Substitute for Smear Microscopy in an Intermediate-Burden Setting
Published in American journal of respiratory and critical care medicine (15-03-2019)“…Use of Xpert MTB/RIF assay as a substitute for smear microscopy in routine clinical practice remains unexplored in an intermediate-tuberculosis-burden setting…”
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Biomarkers for discrimination between latent tuberculosis infection and active tuberculosis disease
Published in The Journal of infection (01-03-2017)“…Summary Objective We aimed to determine whether combinations of multiplex cytokine responses could differentiate Mycobacterium tuberculosis ( Mtb ) infection…”
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HDAC5 inhibition reduces angiotensin II-induced vascular contraction, hypertrophy, and oxidative stress in a mouse model
Published in Biomedicine & pharmacotherapy (01-02-2021)“…•HDAC5 deficiency prevented Ang II-induced hypertension.•HDAC5 deficiency suppressed vascular contraction.•HDAC5 deficiency decreased Ang II-induced ROS…”
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Viral Load Kinetics of SARS-CoV-2 Infection in Saliva in Korean Patients: a Prospective Multi-center Comparative Study
Published in Journal of Korean medical science (10-08-2020)“…This study was performed to compare the viral load and kinetics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in saliva with those in…”
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Activation, Deficiency, and Reduced IFN-γ Production of Mucosal-Associated Invariant T Cells in Patients with Inflammatory Bowel Disease
Published in Journal of innate immunity (01-09-2020)“…Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can activate either in response to T-cell receptor (TCR) engagement or through…”
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Gentisic acid prevents the transition from pressure overload-induced cardiac hypertrophy to heart failure
Published in Scientific reports (28-02-2019)“…We previously reported that gentisic acid attenuates cardiac hypertrophy and fibrosis in transverse aortic constriction (TAC)-induced cardiac hypertrophy…”
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Pediatric humoral immune responses and infection risk after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and two-dose vaccination during SARS-CoV-2 omicron BA.5 and BN.1 variants predominance in South Korea
Published in Frontiers in immunology (20-12-2023)“…Humoral immune responses and infection risk after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019…”
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Performance of Severe Acute Respiratory Syndrome Coronavirus 2 Serological Diagnostic Tests and Antibody Kinetics in Coronavirus Disease 2019 Patients
Published in Frontiers in microbiology (14-04-2022)“…Serological testing is recommended to support the detection of undiagnosed coronavirus disease 2019 (COVID-19) cases. However, the performance of serological…”
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The “Intermediate” CD14 + CD16 + monocyte subpopulation plays a role in IVIG responsiveness of children with Kawasaki disease
Published in Pediatric rheumatology online journal (31-05-2021)“…Background Kawasaki disease (KD) is an acute, self-limited febrile illness of unknown cause. Intravenous immunoglobulin (IVIG)-resistance are related to…”
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Prediction of Mid-term Platelet Transfusion in Stable Trauma Patients Using Rotational Thromboelastometry
Published in Annals of laboratory medicine (01-01-2024)“…BackgroundRotational thromboelastometry (ROTEM; TEM International GmbH, Munich, Germany) is a global coagulation test that guides evidence-based platelet…”
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Whole-Genome Sequence Analysis of Candida glabrata Isolates from a Patient with Persistent Fungemia and Determination of the Molecular Mechanisms of Multidrug Resistance
Published in Journal of fungi (Basel) (26-04-2023)“…Whole-genome sequencing (WGS) was used to determine the molecular mechanisms of multidrug resistance for 10 serial bloodstream isolates obtained from a…”
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