Search Results - "Kee, Anthony"

Male Presence can Increase Body Mass and Induce a Stress-Response in Female Mice Independent of Costs of Offspring Production by Garratt, Michael, Kee, Anthony J., Palme, Rupert, Brooks, Robert C.

“…Sexual reproduction in animals requires close interactions with the opposite sex. These interactions may generate costs of reproduction, because mates can…”
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Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans by Hook, Jeff W, Seto, Jane T, Gunning, Peter W, MacArthur, Daniel G, Quinlan, Kate G, Huttley, Gavin A, Lemckert, Frances A, Hardeman, Edna C, Edwards, Michael R, Berman, Yemima, Easteal, Simon, Kee, Anthony J, North, Kathryn N, Yang, Nan, Raftery, Joanna M

“…More than a billion humans worldwide are predicted to be completely deficient in the fast skeletal muscle fiber protein α-actinin-3 owing to homozygosity for a…”
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An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake by Kee, Anthony J., Yang, Lingyan, Lucas, Christine A., Greenberg, Michael J., Martel, Nick, Leong, Gary M., Hughes, William E., Cooney, Gregory J., James, David E., Ostap, E. Michael, Han, Weiping, Gunning, Peter W., Hardeman, Edna C.

“…Actin has an ill‐defined role in the trafficking of GLUT4 glucose transporter vesicles to the plasma membrane (PM). We have identified novel actin filaments…”
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Tropomyosin isoforms: divining rods for actin cytoskeleton function by Gunning, Peter W., Schevzov, Galina, Kee, Anthony J., Hardeman, Edna C.

“…Actin filament functional diversity is paralleled by variation in the composition of isoforms of tropomyosin in these filaments. Although the role of…”
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Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments by Schevzov, Galina, Kee, Anthony J, Wang, Bin, Sequeira, Vanessa B, Hook, Jeff, Coombes, Jason D, Lucas, Christine A, Stehn, Justine R, Musgrove, Elizabeth A, Cretu, Alexandra, Assoian, Richard, Fath, Thomas, Hanoch, Tamar, Seger, Rony, Pleines, Irina, Kile, Benjamin T, Hardeman, Edna C, Gunning, Peter W

“…ERK-regulated cell proliferation requires multiple phosphorylation events catalyzed first by MEK and then by casein kinase 2 (CK2), followed by interaction…”
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An Actn3 knockout mouse provides mechanistic insights into the association between α-actinin-3 deficiency and human athletic performance by MacArthur, Daniel G., Seto, Jane T., Chan, Stephen, Quinlan, Kate G.R., Raftery, Joanna M., Turner, Nigel, Nicholson, Megan D., Kee, Anthony J., Hardeman, Edna C., Gunning, Peter W., Cooney, Gregory J., Head, Stewart I., Yang, Nan, North, Kathryn N.

“…A common nonsense polymorphism (R577X) in the ACTN3 gene results in complete deficiency of the fast skeletal muscle fiber protein α-actinin-3 in an estimated…”
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On-target action of anti-tropomyosin drugs regulates glucose metabolism by Kee, Anthony J., Chagan, Jayshan, Chan, Jeng Yie, Bryce, Nicole S., Lucas, Christine A., Zeng, Jun, Hook, Jeff, Treutlein, Herbert, Laybutt, D. Ross, Stehn, Justine R., Gunning, Peter W., Hardeman, Edna C.

“…The development of novel small molecule inhibitors of the cancer-associated tropomyosin 3.1 (Tpm3.1) provides the ability to examine the metabolic function of…”
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Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy by Cowling, Belinda S, McGrath, Meagan J, Nguyen, Mai-Anh, Cottle, Denny L, Kee, Anthony J, Brown, Susan, Schessl, Joachim, Zou, Yaqun, Joya, Josephine, Bönnemann, Carsten G, Hardeman, Edna C, Mitchell, Christina A

“…Regulators of skeletal muscle mass are of interest, given the morbidity and mortality of muscle atrophy and myopathy. Four-and-a-half LIM protein 1 (FHL1) is…”
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ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2 by Kee, Anthony J., Bryce, Nicole S., Yang, Lingyan, Polishchuk, Elena, Schevzov, Galina, Weigert, Roberto, Polishchuk, Roman, Gunning, Peter W., Hardeman, Edna C.

“…We have identified novel actin filaments defined by tropomyosin Tpm4.2 at the ER. EM analysis of mouse embryo fibroblasts (MEFs) isolated from mice expressing…”
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Tropomyosin Regulates Cell Migration during Skin Wound Healing by Lees, Justin G., Ching, Yu Wooi, Adams, Damian H., Bach, Cuc T.T., Samuel, Michael S., Kee, Anthony J., Hardeman, Edna C., Gunning, Peter, Cowin, Allison J., O'Neill, Geraldine M.

“…Precise orchestration of actin polymer into filaments with distinct characteristics of stability, bundling, and branching underpins cell migration. A key…”
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Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy by Nguyen, Mai-Anh T., Joya, Josephine E., Kee, Anthony J., Domazetovska, Ana, Yang, Nan, Hook, Jeff W., Lemckert, Frances A., Kettle, Emma, Valova, Valentina A., Robinson, Philip J., North, Kathryn N., Gunning, Peter W., Mitchell, Christina A., Hardeman, Edna C.

“…Nemaline myopathy, the most common congenital myopathy, is caused by mutations in genes encoding thin filament and thin filament-associated proteins in…”
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Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens by Caldwell, Benjamin J., Lucas, Christine, Kee, Anthony J., Gaus, Katharina, Gunning, Peter W., Hardeman, Edna C., Yap, Alpha S., Gomez, Guillermo A.

“…Epithelial cells generate contractile forces at their cell–cell contacts. These are concentrated at the specialized apical junction of the zonula adherens…”
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Diverse roles of the actin cytoskeleton in striated muscle by Kee, Anthony J., Gunning, Peter W., Hardeman, Edna C.

“…In addition to the highly specialized contractile apparatus, it is becoming increasingly clear that there is an extensive actin cytoskeleton which underpins a…”
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Cover Image, Volume 74, Issue 10 by Kee, Anthony J., Bryce, Nicole S., Yang, Lingyan, Polishchuk, Elena, Schevzov, Galina, Weigert, Roberto, Polishchuk, Roman, Gunning, Peter W., Hardeman, Edna C.

“…The cover image, by Anthony J. Kee et al., is based on the Short Report ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2,…”
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Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscle by Vlahovich, Nicole, Kee, Anthony J, Van der Poel, Chris, Kettle, Emma, Hernandez-Deviez, Delia, Lucas, Christine, Lynch, Gordon S, Parton, Robert G, Gunning, Peter W, Hardeman, Edna C

“…The functional diversity of the actin microfilaments relies in part on the actin binding protein tropomyosin (Tm). The muscle-specific Tms regulate…”
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Tropomyosins in skeletal muscle diseases by Kee, Anthony J, Hardeman, Edna C

“…A number of congenital muscle diseases and disorders are caused by mutations in genes that encode the proteins present in or associated with the thin filaments…”
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An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake by Kee, Anthony J., Yang, Lingyan, Lucas, Christine A., Greenberg, Michael J., Martel, Nick, Leong, Gary M., Hughes, William E., Cooney, Gregory J., James, David E., Ostap, E. Michael, Han, Weiping, Gunning, Peter W., Hardeman, Edna C.

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Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice by Garratt, Michael, Pichaud, Nicolas, Glaros, Elias N., Kee, Anthony John, Brooks, Robert C.

“…Oxidative stress (an overproduction of reactive oxygen species in relation to defense mechanisms) may restrict investment in life history traits, such as…”
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Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis by O'Leary, Michael J, Xue, Aiqun, Scarlett, Christopher J, Sevette, Andre, Kee, Anthony J, Smith, Ross C

“…Early nutrition is recommended for patients with sepsis, but data are conflicting regarding the optimum route of delivery. Enteral nutrition (EN), compared…”
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Sorting of a Nonmuscle Tropomyosin to a Novel Cytoskeletal Compartment in Skeletal Muscle Results in Muscular Dystrophy by Kee, Anthony J., Schevzov, Galina, Nair-Shalliker, Visalini, Robinson, C. Stephen, Vrhovski, Bernadette, Ghoddusi, Majid, Qiu, Min Ru, Jim J.-C. Lin, Weinberger, Ron, Gunning, Peter W., Hardeman, Edna C.

“…Tropomyosin (Tm) is a key component of the actin cytoskeleton and >40 isoforms have been described in mammals. In addition to the isoforms in the sarcomere, we…”
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