Search Results - "Kedan, Amir"

Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis by Verma, Nandini, Müller, Anna-Katharina, Kothari, Charu, Panayotopoulou, Effrosini, Kedan, Amir, Selitrennik, Michael, Mills, Gordon B, Nguyen, Lan K, Shin, Sungyoung, Karn, Thomas, Holtrich, Uwe, Lev, Sima

“…Triple-negative breast cancer (TNBC) is a highly aggressive, heterogeneous disease with poor prognosis and no effective targeted therapies. EGFR is highly…”
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Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing by Laufman, Orly, Kedan, Amir, Hong, Wanjin, Lev, Sima

“…The crucial roles of Sec1/Munc18 (SM)‐like proteins in membrane fusion have been evidenced in genetic and biochemical studies. SM proteins interact directly…”
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The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis by Keinan, Omer, Kedan, Amir, Gavert, Nancy, Selitrennik, Michael, Kim, SoHui, Karn, Thomas, Becker, Sven, Lev, Sima

“…The involvement of epithelial-mesenchymal transition (EMT) in breast cancer metastasis has been demonstrated in many studies. However, the intracellular…”
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The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling by Kim, SoHui, Kedan, Amir, Marom, Merav, Gavert, Nancy, Keinan, Omer, Selitrennik, Michael, Laufman, Orly, Lev, Sima

“…Phosphatidic acid (PA) and phosphoinositides are metabolically interconverted lipid second messengers that have central roles in many growth factor…”
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Correction: The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis (doi:10.1242/jcs.155721) by Keinan, Omer, Kedan, Amir, Gavert, Nancy, Selitrennik, Michael, Kim, SoHui, Karn, Thomas, Becker, Sven, Lev, Sima

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PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein by Kedan, Amir, Verma, Nandini, Saroha, Ashish, Shreberk-Shaked, Michal, Müller, Anna-Katharina, Nair, Nishanth Ulhas, Lev, Sima

“…The tumor suppressor Hippo pathway negatively regulates the transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with…”
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Correction: Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis by Verma, Nandini, Müller, Anna-Katharina, Kothari, Charu, Panayotopoulou, Effrosini, Kedan, Amir, Selitrennik, Michael, Mills, Gordon B, Nguyen, Lan K, Shin, Sungyoung, Karn, Thomas, Holtrich, Uwe, Lev, Sima

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The role of Lipid transfer proteins in membrane trafficking and signal transduction by Lev, Sima, Kim, SoHui, Kedan, Amir, Selitrennik, Michael, Keinan, Omer

“…Abstract only Lipid transfer proteins (LTPs) were initially discovered as soluble factors that accelerate the transfer of different lipid species between…”
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The Roles of the Lipid-Transfer Protein Nir2 and Its Interacting Tyrosine Kinase PYK2 in Breast Cancer Invasion and Metastasis by Kedan, Amir

“…Breast cancer is the most prevalent cancer among women, and one of the leading causes of cancer death worldwide. While early detection of primary breast cancer…”
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