Search Results - "Keck, Jacob M"

Exploration of the Role of the C‑Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity by Dougherty, Ashley C, Hawaz, Mariam G, Hoang, Kristine G, Trac, Judy, Keck, Jacob M, Ayes, Carmen, Deweese, Joseph E

“…Human topoisomerase IIα (TOP2A) is a vital nuclear enzyme involved in resolving knots and tangles in DNA during replication and cell division. TOP2A is a…”
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Treatment-emergent cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii is associated with insertion sequence IS Aba36 in the siderophore receptor pirA by Huang, En, Thompson, Rebekah N, Moon, Sun Hee, Keck, Jacob M, Lowry, Michael S, Melero, Joe, Jun, Se-Ran, Rosenbaum, Eric R, Dare, Ryan K

“…We report the emergence of cefiderocol resistance in a carbapenem-resistant isolate from a sacral decubitus ulcer. Cefiderocol was initially used; however, a…”
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Safety, Efficacy, and Effectiveness of Delabeling in Patients with Multiple Drug Allergy Labels by Vethody, Chandra, Yu, Roger, Keck, Jacob M., Onasch, Michelle K., Stone, Cosby A., Phillips, Elizabeth J.

“…Patients with multiple drug allergy labels (MDALs) present a challenging barrier to patient care. To assess the efficacy, safety, and effectiveness of removing…”
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Examination of the Effect of Copper (II) α‐(N)‐Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIβ by Keck, Jacob M., Connor, Jennifer D., Jiang, Xiaohua, Lisic, Edward C., Deweese, Joseph E.

“…During replication, transcription, and cell division, knots and tangles can form in DNA. To relieve this stress, type II topoisomerases are employed, which use…”
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The variable C‐terminal domain of human type II topoisomerases as a functionally relevant therapeutic target by Deweese, Joseph E., Hoang, Kristine G., Menzie, Renee A., Fief, Cole A., Ayes, Carmen A., Keck, Jacob M., Wilson, James T., Cordova, Salvador, Nelson, Chase W.

“…Topoisomerase II is a critical enzyme involved in unknotting and detangling DNA during replication, transcription, and cell division. Humans have two isoforms…”
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