Search Results - "Kechko, Olga I."

Natural Isoforms of Listeria monocytogenes Virulence Factor Inlb Differ in c-Met Binding Efficiency and Differently Affect Uptake and Survival Listeria in Macrophage by Chalenko, Yaroslava M, Slonova, Daria A, Kechko, Olga I, Kalinin, Egor V, Mitkevich, Vladimir A, Ermolaeva, Svetlana A

“…virulence factor InlB specifically interacts with the receptors c-Met and gC1q-R. Both receptors are present in non-professional and professional phagocytes,…”
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Switching On/Off Amyloid Plaque Formation in Transgenic Animal Models of Alzheimer's Disease by Kozin, Sergey A, Kechko, Olga I, Adzhubei, Alexei A, Makarov, Alexander A, Mitkevich, Vladimir A

“…A hallmark of Alzheimer's disease (AD) are the proteinaceous aggregates formed by the amyloid-beta peptide (Aβ) that is deposited inside the brain as amyloid…”
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Aberrant interactions between amyloid-beta and alpha5 laminins as possible driver of neuronal disfunction in Alzheimer’s disease by Rodin, Sergey, Kozin, Sergey A., Kechko, Olga I., Mitkevich, Vladimir A., Makarov, Alexander A.

“…It has been widely accepted that laminins are involved in pathogenesis of Alzheimer’s disease (AD). Amyloid plaques in AD patients are associated with…”
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Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer's Amyloid-β with Taiwan (D7H) Mutation by Kechko, Olga I, Adzhubei, Alexei A, Tolstova, Anna P, Indeykina, Maria I, Popov, Igor A, Zhokhov, Sergey S, Gnuchev, Nikolay V, Mitkevich, Vladimir A, Makarov, Alexander A, Kozin, Sergey A

“…Amyloid-β (Aβ) is a peptide formed by 39-43 amino acids, heterogenous by the length of its C-terminus. Aβ constitutes a subnanomolar monomeric component of…”
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Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin by Nefedova, Victoria V, Kopylova, Galina V, Shchepkin, Daniil V, Kochurova, Anastasia M, Kechko, Olga I, Borzova, Vera A, Ryabkova, Natalia S, Katrukha, Ivan A, Mitkevich, Vladimir A, Bershitsky, Sergey Y, Levitsky, Dmitrii I, Matyushenko, Alexander M

“…Tropomyosin (Tpm) mutations cause inherited cardiac diseases such as hypertrophic and dilated cardiomyopathies. We applied various approaches to investigate…”
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Discrimination between G/C Binding Sites by Olivomycin A Is Determined by Kinetics of the Drug-DNA Interaction by Beniaminov, Artemy D, Chashchina, Galina V, Livshits, Mikhail A, Kechko, Olga I, Mitkevich, Vladimir A, Mamaeva, Olga K, Tevyashova, Anna N, Shtil, Alexander A, Shchyolkina, Anna K, Kaluzhny, Dmitry N

“…Olivomycin A (OA) exerts its cytotoxic potency due to binding to the minor groove of the G/C-rich DNA and interfering with replication and transcription…”
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The English (H6R) Mutation of the Alzheimer's Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation by Radko, Sergey P, Khmeleva, Svetlana A, Kaluzhny, Dmitry N, Kechko, Olga I, Kiseleva, Yana Y, Kozin, Sergey A, Mitkevich, Vladimir A, Makarov, Alexander A

“…The coordination of zinc ions by histidine residues of amyloid-beta peptide (Aβ) plays a critical role in the zinc-induced Aβ aggregation implicated in…”
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Interplay of histidine residues of the Alzheimer’s disease Aβ peptide governs its Zn-induced oligomerization by Istrate, Andrey N., Kozin, Sergey A., Zhokhov, Sergey S., Mantsyzov, Alexey B., Kechko, Olga I., Pastore, Annalisa, Makarov, Alexander A., Polshakov, Vladimir I.

“…Conformational changes of Aβ peptide result in its transformation from native monomeric state to the toxic soluble dimers, oligomers and insoluble aggregates…”
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Williams–Beuren syndrome‐related methyltransferase WBSCR27: cofactor binding and cleavage by Mariasina, Sofia S., Chang, Chi‐Fon, Petrova, Olga A., Efimov, Sergey V., Klochkov, Vladimir V., Kechko, Olga I., Mitkevich, Vladimir A., Sergiev, Petr V., Dontsova, Olga A., Polshakov, Vladimir I.

“…Williams–Beuren syndrome, characterized by numerous physiological and mental problems, is caused by the heterozygous deletion of chromosome region 7q11.23,…”
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Relative Quantitation of Beta-Amyloid Peptide Isomers with Simultaneous Isomerization of Multiple Aspartic Acid Residues by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry by Ivanov, Daniil G, Indeykina, Maria I, Pekov, Stanislav I, Bugrova, Anna E, Kechko, Olga I, Iusupov, Adel E, Kononikhin, Alexey S, Makarov, Alexander A, Nikolaev, Eugene N, Popov, Igor A

“…Matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry can be used for rapid quantitation of peptides with various…”
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SARS-CoV-2 Establishes a Productive Infection in Hepatoma and Glioblastoma Multiforme Cell Lines by Smirnova, Olga A, Ivanova, Olga N, Fedyakina, Irina T, Yusubalieva, Gaukhar M, Baklaushev, Vladimir P, Yanvarev, Dmitry V, Kechko, Olga I, Mitkevich, Vladimir A, Vorobyev, Pavel O, Fedorov, Vyacheslav S, Bartosch, Birke, Valuev-Elliston, Vladimir T, Lipatova, Anastasiya L, Ivanov, Alexander V

“…Severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and rapidly caused a pandemic that led to the death of >6…”
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Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity by Kechko, Olga I, Petrushanko, Irina Yu, Brower, Christopher S, Adzhubei, Alexei A, Moskalev, Alexey A, Piatkov, Konstantin I, Mitkevich, Vladimir A, Makarov, Alexander A

“…Alzheimer's disease (AD) is accompanied by the dysfunction of intracellular protein homeostasis systems, in particular the ubiquitin-proteasome system (UPS)…”
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Amyloid-β peptides slightly affect lifespan or antimicrobial peptide gene expression in Drosophila melanogaster by Shaposhnikov, Mikhail V, Zemskaya, Nadezhda V, Koval, Lyubov А, Minnikhanova, Natalya R, Kechko, Olga I, Mitkevich, Vladimir A, Makarov, Alexander A, Moskalev, Alexey А

“…Beta-amyloid peptide (Aβ) is the key protein in the pathogenesis of Alzheimer's disease, the most common age-related neurodegenerative disorder in humans. Aβ…”
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Bacterial hepatocyte growth factor receptor agonist stimulates hepatocyte proliferation and accelerates liver regeneration in a partial hepatectomy rat model by Kalinin, Egor V., Chalenko, Yaroslava M., Sysolyatina, Elena V., Midiber, Konstantin Y., Gusarov, Alexey M., Kechko, Olga I., Kulikova, Alexandra A., Mikhaleva, Ludmila M., Mukhachev, Andrey Ya, Stanishevskyi, Yaroslav M., Mitkevich, Vladimir A., Sobyanin, Konstantin A., Ermolaeva, Svetlana A.

“…Hepatocyte growth factor (HGF) is central to liver regeneration. The Internalin B (InlB) protein is a virulence factor produced by the pathogenic bacterium…”
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Zinc-induced heterodimer formation between metal-binding domains of intact and naturally modified amyloid-beta species: implication to amyloid seeding in Alzheimer's disease? by Mezentsev, Yuri V., Medvedev, Alexei E., Kechko, Olga I., Makarov, Alexander A., Ivanov, Alexis S., Mantsyzov, Alexey B., Kozin, Sergey A.

“…Zinc ions and modified amyloid-beta peptides (Aβ) play a critical role in the pathological aggregation of endogenous Aβ in Alzheimer's disease (AD)…”
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Natural Isoforms of IListeria monocytogenes/I Virulence Factor Inlb Differ in c-Met Binding Efficiency and Differently Affect Uptake and Survival Listeria in Macrophage by Chalenko, Yaroslava M, Slonova, Daria A, Kechko, Olga I, Kalinin, Egor V, Mitkevich, Vladimir A, Ermolaeva, Svetlana A

“…Listeria monocytogenes virulence factor InlB specifically interacts with the receptors c-Met and gC1q-R. Both receptors are present in non-professional and…”
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The English Mutation of the Alzheimer's Disease Amyloid-[beta] Peptide Modulates Its Zinc-Induced Aggregation by Radko, Sergey P, Khmeleva, Svetlana A, Kaluzhny, Dmitry N, Kechko, Olga I, Kiseleva, Yana Y, Kozin, Sergey A, Mitkevich, Vladimir A, Makarov, Alexander A

“…The coordination of zinc ions by histidine residues of amyloid-beta peptide (A[beta]) plays a critical role in the zinc-induced A[beta] aggregation implicated…”
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Interplay of histidine residues of the Alzheimer's disease A[beta] peptide governs its Zn-induced oligomerization by Istrate, Andrey N, Kozin, Sergey A, Zhokhov, Sergey S, Mantsyzov, Alexey B, Kechko, Olga I, Pastore, Annalisa, Makarov, Alexander A, Polshakov, Vladimir I

“…Conformational changes of Aβ peptide result in its transformation from native monomeric state to the toxic soluble dimers, oligomers and insoluble aggregates…”
Get full text