Search Results - "Kebede, Micheal T"

Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies by Zheng, Qiuchen, Kebede, Micheal T, Kemeh, Merc M, Islam, Saadman, Lee, Bethany, Bleck, Stuart D, Wurfl, Liliana A, Lazo, Noel D

“…The amyloid-β (Aβ) peptide and tau protein are thought to play key neuropathogenic roles in Alzheimer's disease (AD). Both Aβ and tau self-assemble to form the…”
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Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme by Zheng, Qiuchen, Kebede, Micheal T, Lee, Bethany, Krasinski, Claire A, Islam, Saadman, Wurfl, Liliana A, Kemeh, Merc M, Ivancic, Valerie A, Jakobsche, Charles E, Spratt, Donald E, Lazo, Noel D

“…The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aβ42 that has been linked to the neurodegeneration in Alzheimer's disease…”
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Coordination complexes of isoquinoline with cobalt and nickel halides by Bellerive, Michelle A., Kebede, Micheal T., Dickie, Diane A., Landee, Christopher P., Rademeyer, Melanie, Turnbull, Mark M.

“…Reaction of isoquinoline (iQuin) with cobalt(II) and nickel(II) chloride and bromide produced a family of neutral coordination complexes: (iQuin) 2 CoX 2 [X =…”
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Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes by Zheng, Qiuchen, Lee, Bethany, Kebede, Micheal T., Ivancic, Valerie A., Kemeh, Merc M., Brito, Henrique Lemos, Spratt, Donald E., Lazo, Noel D.

“…Insulin-degrading enzyme (IDE) is an evolutionarily conserved ubiquitous zinc metalloprotease implicated in the efficient degradation of insulin monomer…”
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Determinants of the IDE-Dependent Degradation of Insulin by Kebede, Micheal T

“…Insulin-degrading enzyme (IDE) is an attractive target for the development of therapeutic strategies for type-2 diabetes mellitus and Alzheimer’s disease (AD)…”
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