Search Results - "Kebabian, John W."

RBI-257 : A highly potent dopamine D4 receptor-selective ligand by KULA, N. S, BALDESSARINI, R. J, KEBABIAN, J. W, BAKTHAVACHALAM, V, XU, L

“…RBI-257 (1-[4-iodobenzyl]-4-[N-(3-isopropoxy-2-pyridinyl)-N-methyl]-aminopiperid ine), the p-iodobenzyl analog of U-101,958…”
Get full text

Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor by DeNinno, Michael P, Schoenleber, Robert, Perner, Richard J, Lijewski, Linda, Asin, Karen E, Britton, Donald R, MacKenzie, Robert, Kebabian, John W

“…The synthesis and dopaminergic activity of a series of C3 and nitrogen-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans (isochromans) is…”
Get full text

Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission by Kebabian, John W., Greengard, Paul

“…An adenyl cyclase activated by low concentrations of dopamine has been found in the mammalian superior cervical sympathetic ganglion. The existence of this…”
Get full text

Multiple receptors for dopamine by Kebabian, John W, Calne, Donald B

Get full text

Agonist-induced desensitization of the D-2 dopamine receptor in the intermediate lobe of the rat pituitary gland by Agui, T, Amlaiky, N, Caron, M G, Kebabian, J W

“…The mechanism of agonist-induced desensitization of the D-2 dopamine receptor in the intermediate lobe (IL) of the rat pituitary gland was investigated…”
Get more information

Activation of the 5‐HT1c receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393 by Briggs, Clark A., Pollock, Nancy J., Frail, Donald E., Paxson, Cheryl L., Rakowski, Robert F., Kang, Chae Hee, Kebabian, John W.

“…1 A cloned 5‐HT1C receptor expressed in Xenopus laevis oocytes was used to characterize the action of four dopamine D1‐selective benzazepines at the 5‐HT1C…”
Get full text

(1R,3S)-1-(Aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist by DeNinno, Michael P, Schoenleber, Robert, Asin, Karen E, MacKenzie, Robert, Kebabian, John W

Get full text

Multiple classes of dopamine receptors in mammalian central nervous system: the involvement of dopamine-sensitive adenylyl cyclase by Kebabian, J W

Get more information

Dopamine-Sensitive Adenylate Cyclase in Caudate Nucleus of Rat Brain, and Its Similarity to the ``Dopamine Receptor by Kebabian, John W., Petzold, Gary L., Greengard, Paul

“…An adenylate cyclase that is activated specifically by low concentrations of dopamine has been demonstrated in homogenates of caudate nucleus of rat brain. A…”
Get full text

Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands by Michaelides, Michael R, Schoenleber, Robert, Thomas, Sheela, Yamamoto, Diane M, Britton, Donald R, MacKenzie, Robert, Kebabian, John W

“…A series of 3-substituted 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2- benzopyrans were prepared as potential D1 selective antagonists. The compounds were…”
Get full text

Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs by Clement-Cormier, Yvonne C., Kebabian, John W., Petzold, Gary L., Greengard, Paul

“…Adenylate cyclase (EC 4.6.1.1), selectively stimulated by low concentrations of dopamine, has been found in the olfactory tubercle, the nucleus accumbens, and…”
Get full text

Compounds selective for dopamine receptor subtypes by Kebabian, John W., Tarazi, Frank I., Kula, Nora S., Baldessarini, Ross J.

“…Novel dopamine (DA) receptor proteins of relatively low natural abundance and uncertain physiology can be expressed selectively in genetically transfected…”
Get full text

A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets by Kebabian, J W, Britton, D R, DeNinno, M P, Perner, R, Smith, L, Jenner, P, Schoenleber, R, Williams, M

“…A-77636, ((1R,3S) 3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benz opyran hydrochloride), is a selective dopamine D1 receptor agonist. In a…”
Get more information

RBI-257: A highly potent dopamine D 4 receptor-selective ligand by Kula, Nora S, Baldessarini, Ross J, Kebabian, John W, Bakthavachalam, Venkatesalu, Xu, Linxiao

“…RBI-257 (1-[4-iodobenzyl]-4-[ N-(3-isopropoxy-2-pyridinyl)- N-methyl]-aminopiperidine), the p-iodobenzyl analog of U-101,958 (1-benzyl-4-[…”
Get full text

S-(+)-aporphines are not selective for human D3 dopamine receptors by Kula, N S, Baldessarini, R J, Kebabian, J W, Neumeyer, J L

“…1. Our aim was to test the hypothesis that selectivity for D3 dopamine (DA) receptors may contribute to limbic anti-DA selectivity of S-(+)-aporphine DA…”
Get full text

A68930: a potent agonist selective for the dopamine D1 receptor by DeNinno, M P, Schoenleber, R, MacKenzie, R, Britton, D R, Asin, K E, Briggs, C, Trugman, J M, Ackerman, M, Artman, L, Bednarz, L

“…A68930, (1R,3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCl, is a potent (EC50 = 2.5 nM), partial (intrinsic activity = 66% of dopamine) agonist in the…”
Get more information

Isomeric selectivity at dopamine D3 receptors by Baldessarini, R J, Kula, N S, McGrath, C R, Bakthavachalam, V, Kebabian, J W, Neumeyer, J L

“…Racemic 7-hydroxy-N,N-dipropylaminotetralin (7-OH-DPAT) shows greater affinity for limbic-selective dopamine D3 receptors than for more ubiquitous dopamine D2…”
Get more information

Brain dopamine receptors : 20 years of progress by KEBABIAN, J. W

“…I present a brief overview of the contributions of Paul Greengard's laboratory to the field of dopamine receptor research. I show that the work on the…”
Get full text

An iodinated ligand identifying the D-1 dopamine receptor by Sidhu, A, Kebabian, J W

“…Iodination (with 125I) of SKF 83692 (2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol) produces a ligand of high specific activity. In the caudate…”
Get more information

The D-1 dopamine receptor: Past, present and future an idiosyncratic review by Kebabian, John W., Blanchet, Pierre J., Bedard, Paul

“…1. 1. Key events in the experimental investigation of the D-1 dopamine receptor are reviewed. 2. 2. The efficacy of D-1 receptor agonists in the treatment of…”
Get full text