Search Results - "Kebabian, J W"

Differential effect of selective D-1 and D-2 dopamine receptor agonists on levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- exposed monkeys by Blanchet, P, Bédard, P J, Britton, D R, Kebabian, J W

“…The motor effects of selective D-1 dopamine receptor stimulation in Parkinson's disease have been explored in a limited number of studies with partial D-1…”
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Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine by Snyder, GL, Girault, JA, Chen, JY, Czernik, AJ, Kebabian, JW, Nathanson, JA, Greengard, P

“…The molecular mechanisms underlying regulation of fluid production by secretory epithelia such as the choroid plexus are poorly understood. Two cAMP-regulated…”
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Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum by Stoof, J. C, Kebabian, J. W

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Compounds selective for dopamine receptor subtypes by Kebabian, John W., Tarazi, Frank I., Kula, Nora S., Baldessarini, Ross J.

“…Novel dopamine (DA) receptor proteins of relatively low natural abundance and uncertain physiology can be expressed selectively in genetically transfected…”
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A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets by Kebabian, J W, Britton, D R, DeNinno, M P, Perner, R, Smith, L, Jenner, P, Schoenleber, R, Williams, M

“…A-77636, ((1R,3S) 3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benz opyran hydrochloride), is a selective dopamine D1 receptor agonist. In a…”
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Evidence for involvement of both D1 and D2 receptors in maintaining cocaine self-administration by Britton, D R, Curzon, P, Mackenzie, R G, Kebabian, J W, Williams, J E, Kerkman, D

“…Rats trained to self-administer cocaine (0.75 mg/kg/infusion) on an FR-5 schedule were treated with selective D1 or D2 antagonists. A69045, a D1 antagonist…”
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Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor by Tsuruta, K, Frey, E. A, Grewe, C. W, Cote, T. E, Eskay, R. L, Kebabian, J. W

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Activation of the 5‐HT1c receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393 by Briggs, Clark A., Pollock, Nancy J., Frail, Donald E., Paxson, Cheryl L., Rakowski, Robert F., Kang, Chae Hee, Kebabian, John W.

“…1 A cloned 5‐HT1C receptor expressed in Xenopus laevis oocytes was used to characterize the action of four dopamine D1‐selective benzazepines at the 5‐HT1C…”
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Aporphine enantiomers. Interactions with D-1 and D-2 dopamine receptors by Goldman, M E, Kebabian, J W

“…The R(-) and the S(+) enantiomers of apomorphine (APO) and N-n-propyl norapomorphine (NPA) interact with both the D-1 and the D-2 dopamine receptors. R(-)-APO,…”
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A mu-opiate receptor in 7315c tumor tissue mediates inhibition of immunoreactive prolactin release and adenylate cyclase activity by Frey, E A, Kebabian, J W

“…Cells of the 7315c tumor released immunoreactive PRL (IR-PRL). Cholera toxin enhanced this release. Morphine and other opiate agonists inhibited IR-PRL release…”
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[125I]SCH 23982: the ligand of choice for identifying the D-1 dopamine receptor by Sidhu, A, van Oene, J C, Dandridge, P, Kaiser, C, Kebabian, J W

“…[125I]SCH 23982, [125I]8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol, binds reversibly and with high affinity (Kd = 0.7 +/- 0.05 nM) to…”
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A phosphorylation cascade in the basal ganglia of the mammalian brain: regulation by the D-1 dopamine receptor. A mathematical model of known biochemical reactions by Kebabian, J W

“…Stimulation of the dopamine D-1 receptor in the corpus striatum initiates a cascade of biochemical events. These events include: activation of adenylate…”
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Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor by DeNinno, Michael P, Schoenleber, Robert, Perner, Richard J, Lijewski, Linda, Asin, Karen E, Britton, Donald R, MacKenzie, Robert, Kebabian, John W

“…The synthesis and dopaminergic activity of a series of C3 and nitrogen-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans (isochromans) is…”
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D-2 dopamine receptor-mediated inhibition of pro-opiomelanocortin synthesis in rat intermediate lobe. Abolition by pertussis toxin or activators of adenylate cyclase by Cote, T E, Felder, R, Kebabian, J W, Sekura, R D, Reisine, T, Affolter, H U

“…Stimulation of the D-2 dopamine receptor inhibits pro-opiomelanocortin (POMC) synthesis in isolated rat intermediate lobe tissue. Intermediate lobe tissue was…”
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Two dopamine receptors: biochemistry, physiology and pharmacology by Stoof, J C, Kebabian, J W

“…In 1979, two categories of dopamine (DA) receptors (designated as D-1 and D-2) were identified on the basis of the ability of a limited number of agonists and…”
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Bromocriptine-induced changes in the biochemistry, physiology, and histology of the intermediate lobe of the rat pituitary gland by Beaulieu, M, Goldman, M E, Miyazaki, K, Frey, E A, Eskay, R L, Kebabian, J W, Cote, T E

“…Treatment of rats with 2-Br-alpha-ergocryptine (bromocriptine; CB 154) elicits biochemical, physiological, and histological changes in the intermediate lobe…”
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Rapid reversal of denervation supersensitivity of dopamine D1 receptors by l-dopa or a novel dopamine D1 receptor agonist, A68930 by Britton, D R, Kebabian, J W, Curzon, P

“…The present report describes the effects of sub-chronic treatment with l-dopa or with a recently characterized, selective dopamine D1 receptor agonist (A68930)…”
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Brain dopamine receptors : 20 years of progress by KEBABIAN, J. W

“…I present a brief overview of the contributions of Paul Greengard's laboratory to the field of dopamine receptor research. I show that the work on the…”
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An iodinated ligand identifying the D-1 dopamine receptor by Sidhu, A, Kebabian, J W

“…Iodination (with 125I) of SKF 83692 (2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol) produces a ligand of high specific activity. In the caudate…”
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Rapid Changes in Rat Pineal β -adrenergic Receptor: Alterations in l-[3H]alprenolol Binding and Adenylate Cyclase by Kebabian, John W., Zatz, Martin, Romero, Jorge A., Axelrod, Julius

“…The properties of the β -adrenergic receptor which regulates adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in the pineal gland are…”
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