Search Results - "Keay, K.A."

Anatomically specific patterns of glial activation in the periaqueductal gray of the sub-population of rats showing pain and disability following chronic constriction injury of the sciatic nerve by Mor, D, Bembrick, A.L, Austin, P.J, Wyllie, P.M, Creber, N.J, Denyer, G.S, Keay, K.A

“…Abstract Neuropathic pain conditions for which treatment is sought are characterized by complex behavioural disturbances, as well as “pain.” Recent studies…”
Get full text

Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution by Marzagalli, R, Leggio, G.M, Bucolo, C, Pricoco, E, Keay, K.A, Cardile, V, Castorina, S, Salomone, S, Drago, F, Castorina, A

“…Highlights • Dopamine D3 receptor knockout (D3 R−/− ) mice display increased hippocampal volume. • PACAP but not VIP is increased in the hippocampus of D3 R−/−…”
Get full text

Peripheral nerve injury differentially regulates dopaminergic pathways in the nucleus accumbens of rats with either ‘pain alone’ or ‘pain and disability’ by Austin, P.J, Beyer, K, Bembrick, A.L, Keay, K.A

“…Abstract Following unilateral chronic constriction injury (CCI) of the sciatic nerve, histochemical and gene expression changes were examined in the rat…”
Get full text

Rats with altered behaviour following nerve injury show evidence of centrally altered thyroid regulation by Kilburn-Watt, E, Banati, R.B, Keay, K.A

“…Highlights • Rats with altered social behaviour following CCI have altered HPT axis regulation. • Decreased deiodinase 3 in the PVN offers an explanation for…”
Get full text

Hypovolemic shock: Critical involvement of a projection from the ventrolateral periaqueductal gray to the caudal midline medulla by Vagg, D.J, Bandler, R, Keay, K.A

“…Abstract Previous research has suggested that the ventrolateral column of the periaqueductal gray (vlPAG) plays a crucial role in triggering a decompensatory…”
Get full text

384 Nerve injury triggers glial adaptation in the periaqueductal gray (PAG) of rats with disability and pain, but not pain alone by Keay, K.A., Mor, D.

Get full text

159 Differences between inflammatory responses in dorsal root ganglia and spinal cord after chronic constriction or transection of rat sciatic nerve by Hu, P., Bembrick, A.L., Keay, K.A., McLachlan, E.M.

Get full text

Convergence of deep somatic and visceral nociceptive information onto a discrete ventrolateral midbrain periaqueductal gray region by Keay, K A, Clement, C I, Owler, B, Depaulis, A, Bandler, R

“…Pain arising from deep structures (muscles, joints, viscera) is the type of pain of most clinical relevance and also the type of pain about whose central…”
Get more information

pERK-ing up the brainstem after injury by Keay, K.A.

Get full text

The ventrolateral periaqueductal gray projects to caudal brainstem depressor regions: a functional-anatomical and physiological study by Henderson, L.A, Keay, K.A, Bandler, R

“…The reaction of shock, a precipitous, life-threatening fall in arterial pressure and heart rate, is evoked often by the combination of deep pain and blood loss…”
Get full text

Enhanced Fos expression in glutamic acid decarboxylase immunoreactive neurons of the mouse periaqueductal grey during opioid withdrawal by Hacker, J., Pedersen, N.P., Chieng, B.C.H., Keay, K.A., Christie, M.J.

“…Previous studies using c-Fos immunohistochemistry suggest that a sub-population of neurons in the midbrain periaqueductal gray region is activated during…”
Get full text

Noxious activation of spinal or vagal afferents evokes distinct patterns of fos-like immunoreactivity in the ventrolateral periaqueductal gray of unanaesthetised rats by Keay, K.A, Clement, C.I, Matar, W.M, Heslop, D.J, Henderson, L.A, Bandler, R

“…The consequences of a severe traumatic injury—deep pain and haemorrhage—usually evoke a passive emotional coping reaction characterised by: quiescence and…”
Get full text

Haemodynamic response to haemorrhage: distinct contributions of midbrain and forebrain structures by Troy, B.P, Heslop, D.J, Bandler, R, Keay, K.A

“…The haemodynamic response to a fixed volume haemorrhage passes through three distinct phases: a normotensive, compensatory phase; a hypotensive, decompensatory…”
Get full text

Haemorrhage-evoked compensation and decompensation are mediated by distinct caudal midline medullary regions in the urethane-anaesthetised rat by Heslop, D.J, Keay, K.A, Bandler, R

“…Previous research using microinjections of excitatory amino acids suggested that the caudal midline medulla (including nucleus raphe obscurus and nucleus raphe…”
Get full text

Caudal midline medulla mediates behaviourally-coupled but not baroreceptor-mediated vasodepression by Henderson, L.A, Keay, K.A, Bandler, R

“…Within the caudal medulla there are two regions whose activation leads to vasodepression and bradycardia, the caudal ventrolateral medulla and a discrete…”
Get full text

Swim-stress but not opioid withdrawal increases expression of c-Fos immunoreactivity in rat periaqueductal gray neurons which project to the rostral ventromedial medulla by Bellchambers, C.E, Chieng, B, Keay, K.A, Christie, M.J

“…Expression of c-fos-like immunoreactivity has been used as a marker for neuronal activation and is elevated in the periaqueductal gray following stressful and…”
Get full text

Medullary catecholaminergic projections to the ventrolateral periaqueductal gray region activated by halothane anaesthesia by Clement, C.I, Keay, K.A, Bandler, R

“…Under anaesthesia, blood loss and deep pain can evoke a premature, centrally-mediated sympathoinhibition leading to decompensated shock and sometimes even…”
Get full text

Spatiotemporal pattern of ontogenetic expression of calbindin-28/kD in the retinorecipient layers of rat superior colliculus by Dreher, B., Barker, D.A., Bath, M.R., Keay, K.A.

“…Using an antibody against calbindin‐28kD, we have studied the spatial pattern of expression of this protein in the superior colliculi (SC) of four strains of…”
Get full text

N-methyl D-aspartate (NMDA) evoked changes in blood pressure and heart rate from the rat superior colliculus by KEAY, K. A, DEAN, P, REDGRAVE, P

“…Electrical stimulation and microinjections of the GABA antagonist bicuculline methiodide into the superior colliculus (SC) of the anaesthetized rat can evoke…”
Get full text