Search Results - "Keating, Sean"

TDP-43 pathology: From noxious assembly to therapeutic removal by Keating, Sean S., San Gil, Rebecca, Swanson, Molly E.V., Scotter, Emma L., Walker, Adam K.

“…[Display omitted] •Physiological RNA-binding, self-assembly, and LLPS influence TDP-43 aggregation.•Distinct pathological TDP-43 species contribute…”
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Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43 by Keating, Sean S., Bademosi, Adekunle T., San Gil, Rebecca, Walker, Adam K.

“…Aggregation of the RNA-binding protein, TDP-43, is the unifying hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. TDP-43-related…”
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The Paragon Algorithm, a Next Generation Search Engine That Uses Sequence Temperature Values and Feature Probabilities to Identify Peptides from Tandem Mass Spectra by Shilov, Ignat V., Seymour, Sean L., Patel, Alpesh A., Loboda, Alex, Tang, Wilfred H., Keating, Sean P., Hunter, Christie L., Nuwaysir, Lydia M., Schaeffer, Daniel A.

“…The Paragon™ Algorithm, a novel database search engine for the identification of peptides from tandem mass spectrometry data, is presented. Sequence…”
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A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration by San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi, Walker, Adam K.

“…Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD)…”
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Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis by Wright, Amanda L., Della Gatta, Paul A., Le, Sheng, Berning, Britt A., Mehta, Prachi, Jacobs, Kelly R., Gul, Hossai, San Gil, Rebecca, Hedl, Thomas J., Riddell, Winonah R., Watson, Owen, Keating, Sean S., Venturato, Juliana, Chung, Roger S., Atkin, Julie D., Lee, Albert, Shi, Bingyang, Blizzard, Catherine A., Morsch, Marco, Walker, Adam K.

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease commonly treated with riluzole, a small molecule that may act via modulation of…”
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Phenotypic Assays for Characterizing Compound Effects on Induced Pluripotent Stem Cell-Derived Cardiac Spheroids by Sirenko, Oksana, Hancock, Michael K, Crittenden, Carole, Hammer, Matthew, Keating, Sean, Carlson, Coby B, Chandy, Grischa

“…Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is a major challenge in drug discovery. The focus…”
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Discovering Known and Unanticipated Protein Modifications Using MS/MS Database Searching by Tang, Wilfred H, Halpern, Benjamin R, Shilov, Ignat V, Seymour, Sean L, Keating, Sean P, Loboda, Alex, Patel, Alpesh A, Schaeffer, Daniel A, Nuwaysir, Lydia M

“…We present an MS/MS database search algorithm with the following novel features:  (1) a novel protein database structure containing extensive preindexing and…”
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Use PROSEVA study criteria not COVID-19 phenotype to guide proning treatment decisions by Craven, Thomas H, Young, Neil, Keating, Seán, Livesey, John Andrew, Hay, Alasdair

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Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 by Pairo-Castineira, Erola, Rawlik, Konrad, Bretherick, Andrew D., Qi, Ting, Wu, Yang, Nassiri, Isar, McConkey, Glenn A., Zechner, Marie, Klaric, Lucija, Griffiths, Fiona, Oosthuyzen, Wilna, Kousathanas, Athanasios, Richmond, Anne, Millar, Jonathan, Russell, Clark D., Malinauskas, Tomas, Thwaites, Ryan, Morrice, Kirstie, Keating, Sean, Maslove, David, Nichol, Alistair, Semple, Malcolm G., Knight, Julian, Shankar-Hari, Manu, Summers, Charlotte, Hinds, Charles, Horby, Peter, Ling, Lowell, McAuley, Danny, Montgomery, Hugh, Openshaw, Peter J. M., Begg, Colin, Walsh, Timothy, Tenesa, Albert, Flores, Carlos, Riancho, José A., Rojas-Martinez, Augusto, Lapunzina, Pablo, Yang, Jian, Ponting, Chris P., Wilson, James F., Vitart, Veronique, Abedalthagafi, Malak, Luchessi, Andre D., Parra, Esteban J., Cruz, Raquel, Carracedo, Angel, Fawkes, Angie, Murphy, Lee, Rowan, Kathy, Pereira, Alexandre C., Law, Andy, Fairfax, Benjamin, Hendry, Sara Clohisey, Baillie, J. Kenneth

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Neurological outcome following out of hospital cardiac arrest: Evaluation of performance of existing risk prediction models in a UK cohort by Livesey, John A, Lone, Nazir, Black, Emily, Broome, Richard, Syme, Alastair, Keating, Sean, Elliott, Laura, McCahill, Cara, Simpson, Gavin, Grant, Helen, Auld, Fiona, Garrioch, Sweyn, Hay, Alasdair, Craven, Thomas H

“…Introduction: Out of hospital cardiac arrest (OHCA) is a common problem. Rates of survival are low and a proportion of survivors are left with an unfavourable…”
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Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study by Sullivan, Michael K, Lees, Jennifer S, Drake, Thomas M, Docherty, Annemarie B, Oates, Georgia, Hardwick, Hayley E, Russell, Clark D, Merson, Laura, Dunning, Jake, Nguyen-Van-Tam, Jonathan S, Openshaw, Peter, Harrison, Ewen M, Baillie, J Kenneth, Semple, Malcolm G, Ho, Antonia, Mark, Patrick B

“…ABSTRACT Background Acute kidney injury (AKI) is common in coronavirus disease 2019 (COVID-19). This study investigated adults hospitalized with COVID-19 and…”
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Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera by Roper, Kelly J., Thomas, Jordan, Albalawi, Wejdan, Maddocks, Emily, Dobson, Susan, Alshehri, Abdullateef, Barone, Francesco G., Baltazar, Murielle, Semple, Malcolm G., Ho, Antonia, Turtle, Lance, Paxton, William A., Pollakis, Georgios

“…The ongoing SARS-CoV-2 pandemic was initially managed by non-pharmaceutical interventions such as diagnostic testing, isolation of positive cases, physical…”
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First metatarsophalangeal joint implant as a salvage procedure by Allman, L M, Keating, S E

“…First metatarsophalangeal joint implants are used to correct deformity, to restore or improve motion, and to relieve pain. The authors report on a patient with…”
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The best write of my life by Bickle, John, Keating, Sean

“…If e-literature's narrative structures change our brains, what happens to our selves, ask John Bickle and Sean Keating…”
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Chaos foreseen on tax-free shopping by Keating, Sean, Knapp, Jimmy, Harrison, Bill

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