Search Results - "Kearns‐Jonker, M."

The Anti‐Non‐Gal Xenoantibody Response to Xenoantigens on Gal Knockout Pig Cells Is Encoded by a Restricted Number of Germline Progenitors by Kiernan, K., Harnden, I., Gunthart, M., Gregory, C., Meisner, J., Kearns‐Jonker, M.

“…Antibodies directed at non‐gal xenoantigens are responsible for acute humoral xenograft rejection when gal knockout (GalTKO) pig organs are transplanted into…”
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Gene therapy to inhibit xenoantibody production using lentiviral vectors in non-human primates by FISCHER-LOUGHEED, J. Y, TARANTAL, A. F, SHULKIN, I, MITSUHASHI, N, KOHN, D. B, LEE, C. C. I, KEARNS-IONKER, M

“…Xenoantibodies to the gal alpha1,3 gal (gal) epitope impede the use of pig tissues for xenotransplantation, a procedure that may help overcome the shortage of…”
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Expression Changes in Tolerant Murine Cardiac Allografts After Gene Therapy With a Lentiviral Vector Expressing α1,3 Galactosyltransferase by Evans, J.M., Doki, T., Fischer-Lougheed, J., Davicioni, E., Kearns-Jonker, M.

“…Comparison of intragraft gene expression changes in tolerant cardiac allograft models may provide the basis for identifying pathways involved in graft…”
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Human serum reactivity to porcine endothelial cells after antisense-mediated down-regulation of GpIIIa expression by KEARNS-JONKER, M. K, CRAMER, D. V, DANE, L. A, SWENSSON, J. M, MAKOWKA, L

“…The hyperacute rejection of vascularized grafts exchanged between discordant species is a result of the binding of preformed natural antibodies to the…”
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Endogenous cardiac stem cells for the treatment of heart failure by Fuentes, Tania, Kearns-Jonker, Mary

“…Stem cell-based therapies hold promise for regenerating the myocardium after injury. Recent data obtained from phase I clinical trials using endogenous…”
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Rhesus monkeys and baboons develop FVIII inhibitors in response to porcine endothelial cells or islets by Stewart, JM, Tarantal, AF, Hawthorne, WJ, Salvaris, EJ, O’Connell, PJ, Nottle, MB, d’Apice, AJF, Cowan, PJ, Kearns-Jonker, M

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IGVH GENES ENCODING XENOANTIBODIES TO GALTKO XENOANTIGENS IN RHESUS MONKEYS ARE RESTRICTED: 676 by Kearns-Jonker, M, Harnden, I, Kiernan, K, Gunthart, M, Meisner, J, Gregory, C

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Xenoantibody Response to Porcine Islet Cell Transplantation using GTKO, CD55, CD59, and Fucosyl-Transferase Multiple Transgenic Donors by Chen, Y, Stewart, JM, Gunthart, M, Hawthorne, WJ, Salvaris, EJ, O’Connell, PJ, Nottle, MB, d’Apice, AJF, Cowan, PJ, Kearns-Jonker, M

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Transgenic mouse lines that are immunologically tolerant and nontolerant to herpes simplex virus glycoprotein D by Abramczuk, J W, Kearns-Jonker, M, Monell-Torrens, E, Wohlenberg, C, Notkins, A L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen by Mitsuhashi, Noboru, Fischer-Lougheed, Jacqueline, Shulkin, Irina, Kleihauer, Annette, Kohn, Donald B., Weinberg, Kenneth I., Starnes, Vaughn A., Kearns-Jonker, Mary

“…Antibodies (Abs) directed at the Galα1,3Galβ1,4GlcNAc-R (αGal) carbohydrate epitope initiate xenograft rejection. Previously, we have shown that bone marrow…”
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Expression changes in tolerant murine cardiac allografts after gene therapy with a lentiviral vector expressing alpha1,3 galactosyltransferase by Evans, J M, Doki, T, Fischer-Lougheed, J, Davicioni, E, Kearns-Jonker, M

“…Comparison of intragraft gene expression changes in tolerant cardiac allograft models may provide the basis for identifying pathways involved in graft…”
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Characterization of human xenoreactive antibodies in liver failure patients exposed to pig hepatocytes after bioartificial liver treatment : An ex vivo model of pig to human xenotransplantation by BAQUERIZO, A, MHOYAN, A, KEARNS-JONKER, M, ARNAOUT, W. S, SHACKLETON, C, BUSUTTIL, R. W, DEMETRIOU, A. A, CRAMER, D. V

“…There are limited experimental data on the nature of the humoral response elicited in humans against pig antigens. In this study, we have examined the…”
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Identification of the V H genes encoding xenoantibodies in non‐immunosuppressed rhesus monkeys by Kleihauer, Annette, Gregory, Clare R., Borie, Dominic C., Kyles, Andrew E., Shulkin, Irina, Patanwala, Insiyyah, Zahorsky‐Reeves, Joanne, Starnes, Vaughn A., Mullen, Yoko, Todorov, Ivan T., Kearns‐Jonker, Mary

“…Summary The major immunological barrier that prevents the use of wild‐type pig xenografts as an alternative source of organs for human xenotransplantation is…”
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Use of lentiviral vectors to induce long-term tolerance to GAL+ heart grafts by KEARNS-JONKER, Mary, FISCHER-LOUGHEED, Jacqueline, SHULKIN, Irina, KLEIHAUER, Annette, MITSUHASHI, Noboru, KOHN, Donald B, WEINBERG, Kenneth, D'APICE, Anthony J. F, STARNES, Vaughn A, CRAMER, Donald V

“…Tolerance to organ grafts has been achieved by establishing a state of stable mixed-cell chimerism after bone marrow transplantation. Gene therapy has been…”
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Characteristics of immunoglobulin gene usage of the xenoantibody binding to gal-alpha(1,3)gal target antigens in the gal knockout mouse by Nozawa, S, Xing, P X, Wu, G D, Gochi, E, Kearns-Jonker, M, Swensson, J, Starnes, V A, Sandrin, M S, McKenzie, I F, Cramer, D V

“…Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the…”
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DESIGN AND FUNCTIONAL ACTIVITY OF HUMAN SINGLE CHAIN ScFv XENOREACTIVE ANTIBODIES WITH SPECIFICITY FOR THE α-GAL EPITOPE by Kearns-Jonker, M., Swensson, J., Starnes, V., Cramer, D. V.

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The Human Antibody Response to Porcine Xenoantigens Is Encoded by IGHV3-11 and IGHV3-74 IgV sub(H) Germline Progenitors by Kearns-Jonker, M, Swensson, J, Ghiuzeli, C, Chu, W, Osame, Y, Starnes, V, Cramer, D V

“…Preformed and induced Ab responses present a major immunological barrier to the use of pig organs for human xenotransplantation. We generated IgM and IgG gene…”
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Genetic control of the humoral responses to xenografts. III. Identification of the immunoglobulin V sub(H) genes responsible for encoding rat immunoglobin G xenoantibodies to hamster heart grafts by Gochi, E, Wu, G-D, Wakiyama, S, Kearns-Jonker, M, Swensson, J, Cramer, D V

“…We have previously reported that the early phases of the immune response of rats to hamster xenografts are characterized by the production of IgM…”
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Identification, functional analysis and expression in a heterotopic heart transplant model of CXCL9 in the rat by Mitsuhashi, Noboru, Kearns‐Jonker, Mary, Wu, Gordon D., Bowdish, Michael E., Jin, Yang‐Sun, Mencel, Robert, Zahorsky‐Reeves, Joanne, Fischer‐Lougheed, Jacqueline, Weinberg, Kenneth I., Starnes, Vaughn A., Cramer, Donald V.

“…Summary CXCR3 chemokines are of particular interest because of their potential involvement in a variety of inflammatory diseases, including the rejection of…”
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CHARACTERIZATION OF INDUCED IgG AND IgM XENOANTIBODY RESPONSES TO PIG ENDOTHELIUM IN HUMANS by Kearns-Jonker, M., Swensson, J., Chu, W., Starnes, V., Cramer, D. V.

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