Search Results - "Kearns, S."
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Strategic Alignment Between Business and Information Technology: A Knowledge-Based View of Behaviors, Outcome, and Consequences
Published in Journal of management information systems (01-12-2006)“…Senior executives continue to be concerned about factors influencing the business effect of information technology (IT). Prior research has argued that…”
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Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy
Published in PloS one (23-10-2015)“…Primary Open Angle Glaucoma (POAG) is a common neurodegenerative disease characterized by the selective and gradual loss of retinal ganglion cells (RGCs)…”
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Establishing Baseline Radiological Metrics of the Talus and Calcaneus: A Retrospective Analysis of Computed Tomography Imaging in an Irish Cohort
Published in Curēus (Palo Alto, CA) (01-11-2023)“…IntroductionThe subtalar joint anatomy is complex and heterogeneity in its morphology creates unique challenges for foot and ankle surgeons. Anatomical metrics…”
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Retrospective evaluation of leflunomide as an adjunctive therapy in dogs with non‐associative immune‐mediated thrombocytopenia: 20 cases (2008‐2021)
Published in Journal of small animal practice (01-04-2024)“…Objective To describe leflunomide as an adjunctive therapy in the treatment of non‐associative immune‐mediated thrombocytopenia. Materials and Methods A…”
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The past, present and future in scaffold-based tendon treatments
Published in Advanced drug delivery reviews (01-04-2015)“…Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon…”
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Exploring the support needs of Australian parents of young children with Usher syndrome: a qualitative thematic analysis
Published in Orphanet journal of rare diseases (21-03-2024)“…Advancements in genetic testing have led to Usher syndrome now being diagnosed at a much earlier age than in the past, enabling the provision of early…”
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Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma
Published in Ophthalmology (Rochester, Minn.) (01-06-2020)“…Developmental abnormalities of the ocular anterior segment in some cases can lead to ocular hypertension and glaucoma. CPAMD8 is a gene of unknown function…”
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Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration
Published in Nature communications (26-07-2022)“…There are currently no treatments for geographic atrophy, the advanced form of age-related macular degeneration. Hence, innovative studies are needed to model…”
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Childhood and Early Onset Glaucoma Classification and Genetic Profile in a Large Australasian Disease Registry
Published in Ophthalmology (Rochester, Minn.) (01-11-2021)“…To report the relative frequencies of childhood and early onset glaucoma subtypes and their genetic findings in a large single cohort. Retrospective clinical…”
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Patient experiences and perceived value of genetic testing in inherited retinal diseases: a cross-sectional survey
Published in Scientific reports (05-03-2024)“…This study evaluated patient experiences with genetic testing for inherited retinal diseases (IRDs) and the association between underlying knowledge, testing…”
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Mutations in TSPAN12 Cause Autosomal-Dominant Familial Exudative Vitreoretinopathy
Published in American journal of human genetics (12-02-2010)“…Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder of the retinal vascular system. Although mutations in three genes (LRP5, FZD4,…”
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Diathermy versus scalpel incisions for hemiarthroplasty for hip fracture: a randomised prospective trial
Published in European journal of orthopaedic surgery & traumatology (01-01-2024)“…As the age profile of our population expands, we can expect subsequent increase in patients presenting with intracapsular fracture. The onus remains on the…”
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A Resource-Based View of Strategic IT Alignment: How Knowledge Sharing Creates Competitive Advantage
Published in Decision sciences (01-12-2003)“…ABSTRACT A critical decision problem for top management, and the focus of this study, is whether the CEO (chief executive officer) and CIO (chief information…”
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The association between pterygium and conjunctival ultraviolet autofluorescence: The Norfolk Island Eye Study
Published in Acta ophthalmologica (Oxford, England) (01-06-2013)“… Purpose: To investigate the association between conjunctival ultraviolet autofluorescence (UVAF), a biomarker of ocular ultraviolet radiation (UVR)…”
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A novel AFG3L2 mutation close to AAA domain leads to aberrant OMA1 and OPA1 processing in a family with optic atrophy
Published in Acta neuropathologica communications (29-06-2020)“…Abstract Autosomal dominant optic atrophy (ADOA) is a neuro-ophthalmic condition characterized by bilateral degeneration of the optic nerves. Although…”
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A growing challenge: The rise of femoral periprosthetic fractures – An 11-year observational study
Published in The surgeon (Edinburgh) (01-02-2020)“…The demand for joint arthroplasty has risen as our elderly population increases and ages. With this so to has the number of patients suffering periprosthetic…”
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Mutations in TSPAN12 Cause Autosomal-Dominant Familial Exudative Vitreoretinopathy
Published in American journal of human genetics (03-03-2016)Get full text
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Ten Inventions That Shaped Modern Orthopedics
Published in Curēus (Palo Alto, CA) (20-01-2021)“…The current field of orthopedics is the result of many decades of minor and major advancements. The evolution of orthopedics has culminated into the modern…”
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Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma
Published in Cell genomics (08-06-2022)“…To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed…”
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