Search Results - "Kearns, Gregory L."

Functional Biomarkers: an Approach to Bridge Pharmacokinetics and Pharmacodynamics in Pediatric Clinical Trials by Kearns, Gregory L, Artman, Michael

“…Over the past 30 years, much has been learned about the impact of development on drug disposition (i.e., pharmacokinetics). This is not true concerning drug…”
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The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst by Pearce, Robin E, Cohen-Wolkowiez, Michael, Sampson, Mario R, Kearns, Gregory L

“…Despite metronidazole's widespread clinical use since the 1960s, the specific enzymes involved in its biotransformation have not been previously identified…”
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Impact of the CYP2C1917 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect by KEARNS, Gregory L, LEEDER, J. Steven, GAEDIGK, Andrea

“…The impact of the CYP2C19*17 allele on the pharmacokinetics of pantoprazole and omeprazole in previously studied children (n = 40) was explored. When…”
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Evaluating palatability in young children: a mini-review of relevant physiology and assessment techniques by Schluterman, Haley M, Linardos, Constance G, Drulia, Teresa, Marshall, James D, Kearns, Gregory L

“…The palatability of pediatric pharmaceutical products plays a crucial role of influencing medication compliance. Rejection of unpalatable medications can…”
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Peppermint oil effects on the gut microbiome in children with functional abdominal pain by Thapa, Santosh, Luna, Ruth Ann, Chumpitazi, Bruno P., Oezguen, Numan, Abdel‐Rahman, Susan M., Garg, Uttam, Musaad, Salma, Versalovic, James, Kearns, Gregory L., Shulman, Robert J.

“…Peppermint oil (PMO) is effective in the treatment of functional abdominal pain disorders, but its mechanism of action is unclear. Evidence suggests PMO has…”
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How to Conduct Clinical Trials in Children: A Tutorial by Shakhnovich, Valentina, Hornik, Christoph P., Kearns, Gregory L., Weigel, Jaylene, Abdel‐Rahman, Susan M.

“…Despite a growing interest in, and commitment to, implementing pediatric clinical trials, approximately one in every five trials in children fails because of…”
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Utility of the 13C‐pantoprazole breath test as a CYP2C19 phenotyping probe for children by Feldman, Keith, Kearns, Gregory L., Pearce, Robin E., Abdel‐Rahman, Susan M., Steven Leeder, James, Friesen, Alec, Staggs, Vincent S., Gaedigk, Andrea, Weigel, Jaylene, Shakhnovich, Valentina

“…The 13C‐pantoprazole breath test (PAN‐BT) is a safe, noninvasive, in vivo CYP2C19 phenotyping probe for adults. Our objective was to evaluate PAN‐BT…”
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Developmental Changes in Pharmacokinetics and Pharmacodynamics by den Anker, John, Reed, Michael D., Allegaert, Karel, Kearns, Gregory L.

“…Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic…”
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Availability of Oral Formulations Labeled for Use in Young Children in Serbia, Germany and the USA by Bajcetic, Milica, Kearns, Gregory L, Jovanovic, Ida, Brajovic, Milan, van den Anker, John N

“…The paucity of marketed drug products that have been adequately studied in infants and children and subsequently, licensed (or labeled) for pediatric use has…”
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Developmental pharmacology: Drug disposition, action, and therapy in infants and children by KEARNS, Gregory L, ABDEL-RAHMAN, Susan M, ALANDER, Sarah W, BLOWEY, Douglas L, LEEDER, J. Steven, KAUFFMAN, Ralph E

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BIOTRANSFORMATION OF FLUTICASONE: IN VITRO CHARACTERIZATION by PEARCE, Robin E, LEEDER, J. Steven, KEARNS, Gregory L

“…Fluticasone propionate (FTP) is a synthetic trifluorinated glucocorticoid with potent anti-inflammatory action that is commonly used in patients with asthma…”
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Proton Pump Inhibitors in Pediatrics: Mechanism of Action, Pharmacokinetics, Pharmacogenetics, and Pharmacodynamics by Ward, Robert M., Kearns, Gregory L.

“…Proton pump inhibitors (PPIs) have become some of the most frequently prescribed medications for treatment of adults and children. Their effectiveness for…”
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Single-Dose Pharmacokinetics of Intravenous Itraconazole and Hydroxypropyl-β-Cyclodextrin in Infants, Children, and Adolescents by ABDEL-RAHMAN, Susan M, JACOBS, Richard F, BLUMER, Jeffrey L, MASSARELLA, Joseph, KAUFFMAN, Ralph E, BRADLEY, John S, KIMKO, Hui C, KEARNS, Gregory L, SHALAYDA, Kevin, CURTIN, Christopher, MALDONADO, Samuel D

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics by Friesen, Craig A, Neilan, Nancy A, Schurman, Jennifer V, Taylor, Debra L, Kearns, Gregory L, Abdel-Rahman, Susan M

“…We have previously demonstrated the clinical efficacy of montelukast in a randomized double-blind controlled cross-over trial in patients with dyspepsia in…”
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Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose by Bhattacharyya, Sudeepa, Pence, Lisa, Yan, Ke, Gill, Pritmohinder, Luo, Chunqiao, Letzig, Lynda G, Simpson, Pippa M, Kearns, Gregory L, Beger, Richard D, James, Laura P

“…Phospholipids are an important class of lipids that act as building blocks of biological cell membranes and participate in a variety of vital cellular…”
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Cytokines and Toxicity in Acetaminophen Overdose by James, Laura P., Simpson, Pippa M., Farrar, Henry C., Kearns, Gregory L., Wasserman, Gary S., Blumer, Jeffrey L., Reed, Michael D., Sullivan, Janice E., Hinson, Jack A.

“…Several cytokines have been reported to have hepatoprotective properties in animal models of acetaminophen toxicity. To investigate the relationships of…”
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The Need for Pediatric Drug Development by Ward, Robert M., Benjamin, Daniel K., Davis, Jonathan M., Gorman, Richard L., Kauffman, Ralph, Kearns, Gregory L., Murphy, Mary Dianne, Sherwin, Catherine M.T.

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Randomised trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain by Shulman, Robert J., Chumpitazi, Bruno P., Abdel‐Rahman, Susan M., Garg, Uttam, Musaad, Salma, Kearns, Gregory L.

“…Aims Little is known regarding the pharmacokinetics and pharmacodynamics of menthol, the active ingredient in peppermint oil (PMO). Our aim was to investigate…”
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Pharmacokinetic Studies in Neonates: The Utility of an Opportunistic Sampling Design by Leroux, Stéphanie, Turner, Mark A., Guellec, Chantal Barin-Le, Hill, Helen, van den Anker, Johannes N., Kearns, Gregory L., Jacqz-Aigrain, Evelyne, Zhao, Wei

“…Background and Objective The use of an opportunistic (also called scavenged) sampling strategy in a prospective pharmacokinetic study combined with population…”
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Adolescents and Drug Development: Commentary on a Dawning Paradigm Shift by Kearns, Gregory L., Anker, John N.

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