Search Results - "Kearney, J.N."

Evaluation of proteinase inhibitors and free radical inhibitors/scavengers in reducing post-thaw viability loss of cryopreserved skin by Kearney, J.N.

“…Cryopreserved skin must be used immediately after thawing or discarded owing to rapid post-thaw deterioration in viability. This is inconvenient and wasteful…”
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A liquidus tracking approach to the cryopreservation of human cartilage allografts by Kay, A.G., Hoyland, J.A., Rooney, P., Kearney, J.N., Pegg, D.E.

“…In the “liquidus tracking” (LT) approach to cryopreservation both the temperature and the concentration of cryoprotectant (CPA) are controlled such that…”
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Clinical evaluation of skin substitutes by Kearney, J.N.

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Assessment of the biological properties of human split skin allografts disinfected with peracetic acid and preserved in glycerol by Lomas, R.J, Cruse-Sawyer, J.E, Simpson, C, Ingham, E, Bojar, R, Kearney, J.N

“…Skin allografts derived from cadaveric human donors are widely used in the treatment of serious burn injuries and other conditions, such as ulcers. In order to…”
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Effects of a peracetic acid disinfection protocol on the biocompatibility and biomechanical properties of human patellar tendon allografts by Lomas, R J, Jennings, L M, Fisher, J, Kearney, J N

“…Patellar tendon allografts, retrieved from cadaveric human donors, are widely used for replacement of damaged cruciate ligaments. In common with other tissue…”
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An evaluation of the capacity of differently prepared demineralised bone matrices (DBM) and toxic residuals of ethylene oxide (EtOx) to provoke an inflammatory response in vitro by Lomas, R.J., Gillan, H.L., Matthews, J.B., Ingham, E., Kearney, J.N.

“…Demineralised bone matrix (DBM) is a form of allogeneic tissue graft widely used in oral and maxillofacial procedures. There is a long history of controversy…”
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Quality issues in skin banking: a review by Kearney, J.N.

“…Over the last decade the concept of quality in healthcare has gained increasing prominence, not least in the field of skin and tissue banking. This was brought…”
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Validation of radiation dose received by frozen unprocessed and processed bone during terminal sterilisation by EAGLE, M. J, ROONEY, P, LOMAS, R, KEARNEY, J. N

“…Fresh frozen femoral heads (FH) and frozen processed bone (FP) are widely used as a source of allograft bone. The FP bone and some of the FH are terminally…”
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Application of a high-level peracetic acid disinfection protocol to re-process antibiotic disinfected skin allografts by Lomas, R J, Huang, Q, Pegg, D E, Kearney, J N

“…Skin allografts, derived from cadaveric donors, are widely used for the treatment of burns and ulcers. Prior to use in clinical situations, these allografts…”
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Inflammation in acne vulgaris: failure of skin micro-organisms to modulate keratinocyte interleukin 1 alpha production in vitro by Ingham, E, Walters, C E, Eady, E A, Cove, J H, Kearney, J N, Cunliffe, W J

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Human keratinocyte isolation and cell culture: a survey of current practices in the UK by Daniels, J.T., Kearney, J.N., Ingham, E.

“…A survey was conducted to establish current techniques for isolation and culture of human keratinocytes. A questionnaire was sent to all units thought to be…”
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An investigation into the potential of extracellular matrix factors for attachment and proliferation of human keratinocytes on skin substitutes by Daniels, J.T., Kearney, J.N., Ingham, E.

“…The purpose of this investigation was to assess the potential of commercially available extracellular matrix proteins, as enhancers of human keratinocyte…”
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Effect of burn patient serum on fibroblast and keratinocyte cell morphology by Khammo, N., McPhie, P., Settle, J.A.D., Ingham, E., Kearney, J.N.

“…The effect of burn patient serum on fibroblast and keratinocyte cell morphology in culture was investigated using the scanning electron microscope. Serum was…”
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Evaluation of NaOH treatment of human dura mater implants to obviate Creutzfeldt-Jakob disease transmission by Kearney, J N, Johnson, C

“…One of the few disinfectants known to inactivate the causative agent of Creutzfeldt-Jakob Disease is NaOH. In this study, NaOH was evaluated as a possible…”
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Cryopreservation of cultured skin cells by Kearney, J N

“…Cryopreservation of human skin keratinocytes and fibroblast cells has been evaluated using three cryoprotectants at various concentrations, three cooling rates…”
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Effects of cryobiological variables on the survival of skin using a defined murine model by Kearney, J N, Wheldon, L A, Gowland, G

“…Skin from an inbred strain of hairless mouse was used as a homogeneous model tissue for studies of skin cryopreservation. Tetrazolium reductase enzyme activity…”
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Cryopreservation of skin using a murine model: validation of a prognostic viability assay by Kearney, J N, Wheldon, L A, Gowland, G

“…In order to evaluate the many variables that can affect cryopreservation success, a simple, highly reproducible model system is required. We have evaluated the…”
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Evaluation of ethylene oxide sterilization of tissue implants by Kearney, J N, Franklin, U C, Aguirregoicoa, V, Holland, K T

“…The ability of ethylene oxide (ETO) gas to penetrate tissue matrices was evaluated using Bacillus subtilis var niger (NCTC 10073) spore strips sandwiched…”
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The effect of bacterial products on human fibroblast and keratinocyte detachment and viability by Taylor, D, Whatling, C, Kearney, J N, Matthews, B, Holland, K T

“…An in vitro model has been developed to study the effect of soluble bacterial products on the viability and detachment of skin cell types utilized cultured…”
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Antimicrobial properties of antiseptic-impregnated biological dressings by Kearney, J N, Arain, T, Holland, K T

“…Three antiseptics--chlorhexidine acetate, silver nitrate and povidone-iodine--were incorporated into biological dressings (human skin and amnio-chorion) and…”
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