Search Results - "Kearney, Alison L."

Muscle and adipose tissue insulin resistance: malady without mechanism? by Fazakerley, Daniel J., Krycer, James R., Kearney, Alison L., Hocking, Samantha L., James, David E.

“…Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and cardiovascular disease. These disorders have dramatically…”
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Global redox proteome and phosphoproteome analysis reveals redox switch in Akt by Su, Zhiduan, Burchfield, James G., Yang, Pengyi, Humphrey, Sean J., Yang, Guang, Francis, Deanne, Yasmin, Sabina, Shin, Sung-Young, Norris, Dougall M., Kearney, Alison L., Astore, Miro A., Scavuzzo, Jonathan, Fisher-Wellman, Kelsey H., Wang, Qiao-Ping, Parker, Benjamin L., Neely, G. Gregory, Vafaee, Fatemeh, Chiu, Joyce, Yeo, Reichelle, Hogg, Philip J., Fazakerley, Daniel J., Nguyen, Lan K., Kuyucak, Serdar, James, David E.

“…Protein oxidation sits at the intersection of multiple signalling pathways, yet the magnitude and extent of crosstalk between oxidation and other…”
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Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis by Kearney, Alison L, Norris, Dougall M, Ghomlaghi, Milad, Kin Lok Wong, Martin, Humphrey, Sean J, Carroll, Luke, Yang, Guang, Cooke, Kristen C, Yang, Pengyi, Geddes, Thomas A, Shin, Sungyoung, Fazakerley, Daniel J, Nguyen, Lan K, James, David E, Burchfield, James G

“…The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid…”
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Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice by Tolman, Nicholas G, Balasubramanian, Revathi, Macalinao, Danilo G, Kearney, Alison L, MacNicoll, Katharine H, Montgomery, Christa L, de Vries, Wilhelmine N, Jackson, Ian J, Cross, Sally H, Kizhatil, Krishnakumar, Nair, K Saidas, John, Simon W M

“…Variants in the LIM homeobox transcription factor 1-beta ( ) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for…”
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Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice by Nair, K Saidas, Hmani-Aifa, Mounira, Ali, Zain, Kearney, Alison L, Salem, Salma Ben, Macalinao, Danilo G, Cosma, Ioan M, Bouassida, Walid, Hakim, Bochra, Benzina, Zeineb, Soto, Ileana, Söderkvist, Peter, Howell, Gareth R, Smith, Richard S, Ayadi, Hammadi, John, Simon W M

“…Simon John and Mounira Hmani-Aifa and colleagues show that mutation of the serine protease gene Prss56 causes elevated intraocular pressure and angle closure…”
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Permeabilization of Drosophila embryos for introduction of small molecules by Rand, Matthew D., Kearney, Alison L., Dao, Julie, Clason, Todd

“…Pharmacological manipulations in the Drosophila embryo have been hindered by the impermeability of the eggshell. The ultimate barrier to delivery of small…”
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Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression by Norris, Dougall, Yang, Pengyi, Shin, Sung-Young, Kearney, Alison L., Kim, Hani Jieun, Geddes, Thomas, Senior, Alistair M., Fazakerley, Daniel J., Nguyen, Lan K., James, David E., Burchfield, James G.

“…Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of GLUT4 to the cell surface. Here we examined the origins of…”
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A New Wave of PI3Kα Inhibitors by Kearney, Alison L, Vasan, Neil

“…This is the first peer-reviewed report of an allosteric, mutant-selective PI3Kα inhibitor, STX-478, that reduces PIK3CA-mutant tumor growth in mice. However,…”
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Structural insights into Ras regulation by SIN1 by Zheng, Yuyuan, Ding, Lei, Meng, Xianhui, Potter, Meg, Kearney, Alison L, Zhang, Jie, Sun, Jie, James, David E, Yang, Guang, Zhou, Chun

“…Over the years it has been established that SIN1, a key component of mTORC2, could interact with Ras family small GTPases through its Ras-binding domain (RBD)…”
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Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes by Kearney, Alison L., Cooke, Kristen C., Norris, Dougall M., Zadoorian, Armella, Krycer, James R., Fazakerley, Daniel J., Burchfield, James G., James, David E.

“…The Ser/Thr protein kinase Akt regulates essential biological processes such as cell survival, growth, and metabolism. Upon growth factor stimulation, Akt is…”
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A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation by Cross, Sally H, Macalinao, Danilo G, McKie, Lisa, Rose, Lorraine, Kearney, Alison L, Rainger, Joe, Thaung, Caroline, Keighren, Margaret, Jadeja, Shalini, West, Katrine, Kneeland, Stephen C, Smith, Richard S, Howell, Gareth R, Young, Fiona, Robertson, Morag, van t' Hof, Rob, John, Simon W. M, Jackson, Ian J

“…Mutations in the LIM-homeodomain transcription factor LMX1B cause nail-patella syndrome, an autosomal dominant pleiotrophic human disorder in which nail,…”
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A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected] by Cross, Sally H, Macalinao, Danilo G, McKie, Lisa, Rose, Lorraine, Kearney, Alison L, Rainger, Joe, Thaung, Caroline, Keighren, Margaret, Jadeja, Shalini, West, Katrine, Kneeland, Stephen C, Smith, Richard S, Howell, Gareth R, Young, Fiona, Robertson, Morag, van T' Hof, Rob, John, Simon W M, Jackson, Ian J

“…Mutations in the LIM-homeodomain transcription factor LMX1B cause nail-patella syndrome, an autosomal dominant pleiotrophic human disorder in which nail,…”
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A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation: e1004359 by Cross, Sally H, Macalinao, Danilo G, McKie, Lisa, Rose, Lorraine, Kearney, Alison L, Rainger, Joe, Thaung, Caroline, Keighren, Margaret, Jadeja, Shalini, West, Katrine, Kneeland, Stephen C, Smith, Richard S, Howell, Gareth R, Young, Fiona, Robertson, Morag, John, Simon WM, Jackson, Ian J

“…Mutations in the LIM-homeodomain transcription factor LMX1B cause nail-patella syndrome, an autosomal dominant pleiotrophic human disorder in which nail,…”
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Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalamia in humans and mice by Nair, K Saidas, Hmani-Aifa, Mounira, Ali, Zain, Kearney, Alison L, Salem, Salma Ben, Macalinao, Danilo G, Cosma, Ioan M, Bouassida, Walid, Hakim, Bochra, Benzina, Zeineb, Soto, Ileana, Söderkvist, Peter, Howell, Gareth R, Smith, Richard S, Ayadi, Hammadi, John, Simon W M

“…Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people 1 – 3 . Although 4 million people are bilaterally blind from ACG 4 , 5 , the…”
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