Search Results - "Keaney, F"

Reactive oxygen species in cardiovascular disease by Sugamura, Koichi, Keaney, John F.

“…Based on the “free radical theory” of disease, researchers have been trying to elucidate the role of oxidative stress from free radicals in cardiovascular…”
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Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications by Münzel, Thomas, Gori, Tommaso, Keaney, Jr, John F, Maack, Christoph, Daiber, Andreas

“…Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local…”
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Role of Oxidative Modifications in Atherosclerosis by Stocker, Roland, Keaney, John F., Jr

“…Centre for Vascular Research, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales, Australia; and…”
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Reactive Oxygen Species in Endothelial Function　– From Disease to Adaptation by Craige, Siobhan M., Kant, Shashi, Keaney, John F., Jr

“…Endothelial function is largely dictated by its ability to rapidly sense environmental cues and adapt to these stimuli through changes in vascular tone,…”
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Bempedoic Acid and the Prevention of Cardiovascular Disease by Keaney, John F.

“…This editorial describes the science behind a study of bempedoic acid in persons with or at increased risk for cardiovascular disease who were unable or…”
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The clinical implications of endothelial dysfunction by Widlansky, Michael E, Gokce, Noyan, Keaney, John F, Vita, Joseph A

“…Defining new approaches for the prevention and treatment of atherosclerosis is an important priority. Recently, measurement of endothelial function in patients…”
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Regulation of ROS Signal Transduction by NADPH Oxidase 4 Localization by Chen, Kai, Kirber, Michael T., Xiao, Hui, Yang, Yu, Keaney, John F.

“…Reactive oxygen species (ROS) function as intracellular signaling molecules in a diverse range of biological processes. However, it is unclear how freely…”
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NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation by CRAIGE, Siobhan M, KAI CHEN, YONGMEI PEI, CHUNYING LI, XIAOYUN HUANG, CHEN, Christine, SHIBATA, Rei, SATO, Kaori, WALSH, Kenneth, KEANEY, John F

“…BACKGROUND- Reactive oxygen species serve signaling functions in the vasculature, and hypoxia has been associated with increased reactive oxygen species…”
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Hdac3 regulates lymphovenous and lymphatic valve formation by Janardhan, Harish P, Milstone, Zachary J, Shin, Masahiro, Lawson, Nathan D, Keaney, Jr, John F, Trivedi, Chinmay M

“…Lymphedema, the most common lymphatic anomaly, involves defective lymphatic valve development; yet the epigenetic modifiers underlying lymphatic valve…”
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Evolving Concepts of Oxidative Stress and Reactive Oxygen Species in Cardiovascular Disease by Chen, Kai, Keaney, John F.

“…Cardiovascular disease (CVD) continues to be a substantial health-care burden, despite recent treatment advances. Oxidative stress has long been regarded as a…”
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Proof That Lower Is Better — LDL Cholesterol and IMPROVE-IT by Jarcho, John A, Keaney, John F

“…The so-called LDL hypothesis is the concept that excess low-density lipoprotein (LDL) cholesterol is a causal factor in the development of atherosclerotic…”
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Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions by Craige, Siobhan M., Kant, Shashi, Reif, Michaella, Chen, Kai, Pei, Yongmei, Angoff, Rebecca, Sugamura, Koichi, Fitzgibbons, Timothy, Keaney, John F.

“…Vascular reactive oxygen species (ROS) are known to be involved in atherosclerosis development and progression. NADPH oxidase 4 (Nox4) is a constitutively…”
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Endothelial function: a barometer for cardiovascular risk? by Vita, Joseph A, Keaney, Jr, John F

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Physical Inactivity Rapidly Induces Insulin Resistance and Microvascular Dysfunction in Healthy Volunteers by Hamburg, Naomi M, McMackin, Craig J, Huang, Alex L, Shenouda, Sherene M, Widlansky, Michael E, Schulz, Eberhard, Gokce, Noyan, Ruderman, Neil B, Keaney, John F, Vita, Joseph A

“…OBJECTIVES—Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked…”
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Volume-Outcome Relationship of Resternotomy Coronary Artery Bypass Grafting by Rappoport, Nadav, Shahian, David M., Galai, Noya, Aviel, Gal, Keaney, John F., Shapira, Oz M.

“…We assessed volume-outcome relationships of resternotomy coronary artery bypass grafting (CABG). We studied 1,362,218 first-time CABG and 93,985 resternotomy…”
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Common Statistical Pitfalls in Basic Science Research by Sullivan, Lisa M., Weinberg, Janice, Keaney, John F.

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Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress : The framingham heart study by POU, Karla M, MASSARO, Joseph M, MURABITO, Joanne M, O'DONNELL, Christopher J, BENJAMIN, Emelia J, FOX, Caroline S, HOFFMANN, Udo, VASAN, Ramachandran S, MAUROVICH-HORVAT, Pal, LARSON, Martin G, KEANEY, John F, MEIGS, James B, LIPINSKA, Izabella, KATHIRESAN, Sekar

“…Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is…”
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Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study by Li, Wenyuan, Dorans, Kirsten S, Wilker, Elissa H, Rice, Mary B, Ljungman, Petter L, Schwartz, Joel D, Coull, Brent A, Koutrakis, Petros, Gold, Diane R, Keaney, John F, Vasan, Ramachandran S, Benjamin, Emelia J, Mittleman, Murray A

“…OBJECTIVE—The objective of this study is to examine associations between short-term exposure to ambient air pollution and circulating biomarkers of systemic…”
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Hydrogen Peroxide Activates Endothelial Nitric-oxide Synthase through Coordinated Phosphorylation and Dephosphorylation via a Phosphoinositide 3-Kinase-dependent Signaling Pathway by Thomas, Shane R., Chen, Kai, Keaney, John F.

“…Endothelial nitric-oxide synthase (eNOS) is an important component of vascular homeostasis. During vascular disease, endothelial cells are exposed to excess…”
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Extracorporeal CPR in Out-of-Hospital Cardiac Arrest — Still on Life Support? by Keaney, John F., Münzel, Thomas

“…Despite many advances in the treatment of heart disease over the past four decades, up to one third of all patients with acute manifestations of heart disease…”
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