Search Results - "Keane, Páraic M."

Spectro-electrochemical Studies on [Ru(TAP)2(dppz)]2+Insights into the Mechanism of its Photosensitized Oxidation of Oligonucleotides by Keane, Páraic M, Tory, Joanne, Towrie, Michael, Sazanovich, Igor V, Cardin, Christine J, Quinn, Susan J, Hartl, František, Kelly, John M, Long, Conor

“…[Ru­(TAP)2(dppz)]2+ (TAP = 1,4,5,8-tetraazaphenanthrene; dppz = dipyrido­[3,2-a:2′,3′-c]­phenazine) is known to photo-oxidize guanine in DNA. Whether this…”
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Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex by Keane, Páraic M., Poynton, Fergus E., Hall, James P., Sazanovich, Igor V., Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J., Cardin, Christine J., Kelly, John M.

“…Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo‐oxidation by Λ‐[Ru(TAP)2(dppz)]2+ have been…”
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Delta chirality ruthenium 'light-switch' complexes can bind in the minor groove of DNA with five different binding modes by Hall, James P, Keane, Páraic M, Beer, Hanna, Buchner, Katrin, Winter, Graeme, Sorensen, Thomas L, Cardin, David J, Brazier, John A, Cardin, Christine J

“…[Ru(phen) (dppz)] has been studied since the 1990s due to its 'light-switch' properties. It can be used as a luminescent DNA probe, with emission switched on…”
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Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen) 2 (dppz)] 2+ light-switch compound in solution and when bound to DNA by Poynton, Fergus E, Hall, James P, Keane, Páraic M, Schwarz, Christine, Sazanovich, Igor V, Towrie, Michael, Gunnlaugsson, Thorfinnur, Cardin, Christine J, Cardin, David J, Quinn, Susan J, Long, Conor, Kelly, John M

“…The [Ru(phen) (dppz)] complex ( ) is non-emissive in water but is highly luminescent in organic solvents or when bound to DNA, making it a useful probe for DNA…”
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Enantiomeric Conformation Controls Rate and Yield of Photoinduced Electron Transfer in DNA Sensitized by Ru(II) Dipyridophenazine Complexes by Keane, Páraic M, Poynton, Fergus E, Hall, James P, Clark, Ian P, Sazanovich, Igor V, Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J, Cardin, Christine J, Kelly, John M

“…Photosensitized oxidation of guanine is an important route to DNA damage. Ruthenium polypyridyls are very useful photosensitizers, as their reactivity and…”
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Long-lived excited states in i-motif DNA studied by picosecond time-resolved IR spectroscopy by Keane, Páraic M, Wojdyla, Michal, Doorley, Gerard W, Kelly, John M, Parker, Anthony W, Clark, Ian P, Greetham, Gregory M, Towrie, Michael, Magno, Luís M, Quinn, Susan J

“…The transient IR absorption spectrum for UV-excited i-motif DNA is reported for the first time and found to possess complex dynamics pointing to multiple decay…”
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A Comparative Picosecond Transient Infrared Study of 1-Methylcytosine and 5′-dCMP That Sheds Further Light on the Excited States of Cytosine Derivatives by Keane, Páraic M, Wojdyla, Michal, Doorley, Gerard W, Watson, Graeme W, Clark, Ian P, Greetham, Gregory M, Parker, Anthony W, Towrie, Michael, Kelly, John M, Quinn, Susan J

“…The role of N1-substitution in controlling the deactivation processes in photoexcited cytosine derivatives has been explored using picosecond time-resolved IR…”
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Long-Lived Excited-State Dynamics of i-Motif Structures Probed by Time-Resolved Infrared Spectroscopy by Keane, Páraic M., Baptista, Frederico R., Gurung, Sarah P., Devereux, Stephen J., Sazanovich, Igor V., Towrie, Michael, Brazier, John A., Cardin, Christine J., Kelly, John M., Quinn, Susan J.

“…UV‐generated excited states of cytosine (C) nucleobases are precursors to mutagenic photoproduct formation. The i‐motif formed from C‐rich sequences is known…”
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Ground and excited state interactions of metalloporphyrin PtTMPyP4 with polynucleotides [poly(dG-dC)]2 and [poly(dA-dT)]2 by Keane, Páraic M, Kelly, John M

“…The ground- and excited-state interactions of Pt(ii) meso-tetrakis(4-N-methylpyridyl)porphyrin (PtTMPyP4) with polynucleotides [poly(dG-dC)]2 and…”
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Triplet-state dynamics of a metalloporphyrin photosensitiser (PtTMPyP4) in the presence of halides and purine mononucleotides by Keane, Páraic M, Kelly, John M

“…The photophysical properties of Pt(II) meso-tetrakis(4-N-methylpyridyl)porphyrin (PtTMPyP4) have been investigated in the presence of purine mononucleotides…”
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Photophysical studies of CdTe quantum dots in the presence of a zinc cationic porphyrin by Keane, Páraic M, Gallagher, Shane A, Magno, Luís M, Leising, Miriam J, Clark, Ian P, Greetham, Gregory M, Towrie, Michael, Gun'ko, Yurii K, Kelly, John M, Quinn, Susan J

“…The photophysical properties of 2.3 nm thioglycolic acid (TGA) coated CdTe quantum dots (QDs) prepared by a reflux method have been studied in the presence of…”
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Monitoring guanine photo-oxidation by enantiomerically resolved Ru(II) dipyridophenazine complexes using inosine-substituted oligonucleotides by Keane, Páraic M, Poynton, Fergus E, Hall, James P, Clark, Ian P, Sazanovich, Igor V, Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J, Cardin, Christine J, Kelly, John M

“…The intercalating [Ru(TAP)2(dppz)](2+) complex can photo-oxidise guanine in DNA, although in mixed-sequence DNA it can be difficult to understand the precise…”
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Transient absorption and time-resolved vibrational studies of photophysical and photochemical processes in DNA-intercalating polypyridyl metal complexes or cationic porphyrins by Keane, Páraic M., Kelly, John M.

“…[Display omitted] •Time-resolved IR (TRIR) resolves excited states of Ru-dppz ‘light-switch’ complex.•Markers for guanine photo-oxidation in Ru/Re complexes…”
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Study of picosecond processes of an intercalated dipyridophenazine Cr(III) complex bound to defined sequence DNAs using transient absorption and time-resolved infrared methods by Devereux, Stephen J, Keane, Páraic M, Vasudevan, Suni, Sazanovich, Igor V, Towrie, Michael, Cao, Qian, Sun, Xue-Zhong, George, Michael W, Cardin, Christine J, Kane-Maguire, Noel A P, Kelly, John M, Quinn, Susan J

“…Picosecond transient absorption (TA) and time-resolved infrared (TRIR) measurements of rac-[Cr(phen)2(dppz)](3+) () intercalated into double-stranded…”
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Frontispiece: Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex by Keane, Páraic M., Poynton, Fergus E., Hall, James P., Sazanovich, Igor V., Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J., Cardin, Christine J., Kelly, John M.

“…DNA Photooxidation Small changes in DNA sequence can have major biological effects. P. M. Keane, C. J. Cardin, J. M. Kelly et al. show on page 8364 ff. that…”
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Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy by Hall, James P., Poynton, Fergus E., Keane, Páraic M., Gurung, Sarah P., Brazier, John A., Cardin, David J., Winter, Graeme, Gunnlaugsson, Thorfinnur, Sazanovich, Igor V., Towrie, Michael, Cardin, Christine J., Kelly, John M., Quinn, Susan J.

“…To understand the molecular origins of diseases caused by ultraviolet and visible light, and also to develop photodynamic therapy, it is important to resolve…”
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Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen)(dppz)] light-switch compound in solution and when bound to DNA by Poynton, Fergus E, Hall, James P, Keane, Páraic M, Schwarz, Christine, Sazanovich, Igor V, Towrie, Michael, Gunnlaugsson, Thorfinnur, Cardin, Christine J, Cardin, David J, Quinn, Susan J, Long, Conor, Kelly, John M

“…The [Ru(phen) 2 (dppz)] 2+ complex ( 1 ) is non-emissive in water but is highly luminescent in organic solvents or when bound to DNA, making it a useful probe…”
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Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex by Keane, Páraic M., Poynton, Fergus E., Hall, James P., Sazanovich, Igor V., Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J., Cardin, Christine J., Kelly, John M.

“…Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo‐oxidation by Λ‐[Ru(TAP)2(dppz)]2+ have been…”
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Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a Ru II Complex due to Structural Change in the Minor Groove by Keane, Páraic M, Hall, James P, Poynton, Fergus E, Poulsen, Bjørn C, Gurung, Sarah P, Clark, Ian P, Sazanovich, Igor V, Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J, Cardin, Christine J, Kelly, John M

“…Key to the development of DNA-targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference…”
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Understanding the factors controlling the photo-oxidation of natural DNA by enantiomerically pure intercalating ruthenium polypyridyl complexes through TA/TRIR studies with polydeoxynucleotides and mixed sequence oligodeoxynucleotides by Keane, Páraic M, O'Sullivan, Kyra, Poynton, Fergus E, Poulsen, Bjørn C, Sazanovich, Igor V, Towrie, Michael, Cardin, Christine J, Sun, Xue-Zhong, George, Michael W, Gunnlaugsson, Thorfinnur, Quinn, Susan J, Kelly, John M

“…Ruthenium polypyridyl complexes which can sensitise the photo-oxidation of nucleic acids and other biological molecules show potential for photo-therapeutic…”
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