Search Results - "Keane, Fiona M"

Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy by Hamson, Elizabeth J., Keane, Fiona M., Tholen, Stefan, Schilling, Oliver, Gorrell, Mark D.

“…Fibroblast activation protein (FAP) is best known for its heightened expression in tumour stroma. This atypical serine protease has both dipeptidyl peptidase…”
Get full text

Advances in understanding the expression and function of dipeptidyl peptidase 8 and 9 by Zhang, Hui, Chen, Yiqian, Keane, Fiona M, Gorrell, Mark D

“…DPP8 and DPP9 are recently identified members of the dipeptidyl peptidase IV (DPPIV) enzyme family, which is characterized by the rare ability to cleave a…”
Get full text

Identification of novel dipeptidyl peptidase 9 substrates by two‐dimensional differential in‐gel electrophoresis by Zhang, Hui, Maqsudi, Sadiqa, Rainczuk, Adam, Duffield, Nadine, Lawrence, Josie, Keane, Fiona M, Justa‐Schuch, Daniela, Geiss‐Friedlander, Ruth, Gorrell, Mark D, Stephens, Andrew N

“…Dipeptidyl peptidase 9 (DPP9) is a member of the S9B/DPPIV (DPP4) serine protease family, which cleaves N‐terminal dipeptides at an Xaa‐Pro consensus motif…”
Get full text

Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease by Uitte de Willige, Shirley, Keane, Fiona M, Bowen, David G, Malfliet, Joyce J M C, Zhang, H Emma, Maneck, Bharvi, McCaughan, Geoffrey W, Leebeek, Frank W G, Rijken, Dingeman C, Gorrell, Mark D

“…Circulating fibroblast activation protein (cFAP) is a constitutively active enzyme expressed by activated fibroblasts that has both dipeptidyl peptidase and…”
Get full text

Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs by Keane, Fiona M., Yao, Tsun-Wen, Seelk, Stefanie, Gall, Margaret G., Chowdhury, Sumaiya, Poplawski, Sarah E., Lai, Jack H., Li, Youhua, Wu, Wengen, Farrell, Penny, Vieira de Ribeiro, Ana Julia, Osborne, Brenna, Yu, Denise M.T., Seth, Devanshi, Rahman, Khairunnessa, Haber, Paul, Topaloglu, A. Kemal, Wang, Chuanmin, Thomson, Sally, Hennessy, Annemarie, Prins, John, Twigg, Stephen M., McLennan, Susan V., McCaughan, Geoffrey W., Bachovchin, William W., Gorrell, Mark D.

“…The protease fibroblast activation protein (FAP) is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. A specific, reliable…”
Get full text

Sequence diversity in the A domain of Staphylococcus aureus fibronectin-binding protein A by Loughman, Anthony, Sweeney, Tara, Keane, Fiona M, Pietrocola, Giampiero, Speziale, Pietro, Foster, Timothy J

“…Fibronectin-binding protein A (FnBPA) mediates adhesion of Staphylococcus aureus to fibronectin, fibrinogen and elastin. We previously reported that S. aureus…”
Get full text

Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α by Keane, Fiona M, Nadvi, Naveed A, Yao, Tsun-Wen, Gorrell, Mark D

“…Fibroblast activation protein-α (FAP) is a cell surface-expressed and soluble enzyme of the prolyl oligopeptidase family, which includes dipeptidyl peptidase 4…”
Get full text

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics[S] by Zhang, Hui Emma, Hamson, Elizabeth J., Koczorowska, Maria Magdalena, Tholen, Stefan, Chowdhury, Sumaiya, Bailey, Charles G., Lay, Angelina J., Twigg, Stephen M., Lee, Quintin, Roediger, Ben, Biniossek, Martin L., O'Rourke, Matthew B., McCaughan, Geoffrey W., Keane, Fiona M., Schilling, Oliver, Gorrell, Mark D.

“…Fibroblast activation protein-α (FAP) can hydrolyze the post-proline bond. We identified endogenous substrates of FAP in fibroblasts that were previously naive…”
Get full text

Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin by Zhang, Hui, Chen, Yiqian, Wadham, Carol, McCaughan, Geoffrey W., Keane, Fiona M., Gorrell, Mark D.

“…Dipeptidyl peptidase 9 (DPP9) is a ubiquitously expressed member of the DPP4 gene and protease family. Deciphering the biological functions of DPP9 and its…”
Get full text

Eosinophilic pustular folliculitis induced by chemotherapy by Laing, Mary Elizabeth, Laing, Tereze Ann, Mulligan, Niall J., Keane, Fiona M.

Get full text

Fibrinogen and elastin bind to the same region within the A domain of fibronectin binding protein A, an MSCRAMM of Staphylococcus aureus by Keane, Fiona M, Loughman, Anthony, Valtulina, Viviana, Brennan, Marian, Speziale, Pietro, Foster, Timothy J

“…The fibronectin binding protein, FnBPA, is a multifunctional microbial surface component recognizing adhesive matrix molecule (MSCRAMM) that promotes bacterial…”
Get full text

Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma by Wong, Pok Fai, Gall, Margaret G., Bachovchin, William W., McCaughan, Geoffrey W., Keane, Fiona M., Gorrell, Mark D.

“…•Measured FAP and DPP4 enzyme kinetics on 4 neuropeptides in mouse and human plasma.•NPY is a physiological substrate of endogenous FAP, DPP4 and plasma…”
Get full text

Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes by Chen, Yiqian, Gall, Margaret G., Zhang, Hui, Keane, Fiona M., McCaughan, Geoffrey W., Yu, Denise M.T., Gorrell, Mark D.

“…The success of dipeptidyl peptidase 4 (DPP4) inhibition as a type 2 diabetes therapy has encouraged deeper examination of the post-proline DPP enzymes. DPP9…”
Get full text

Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study by Williams, Kathryn H., Vieira De Ribeiro, Ana Júlia, Prakoso, Emilia, Veillard, Anne-Sophie, Shackel, Nicholas A., Brooks, Belinda, Bu, Yangmin, Cavanagh, Erika, Raleigh, Jim, McLennan, Susan V., McCaughan, Geoffrey W., Keane, Fiona M., Zekry, Amany, Gorrell, Mark D., Twigg, Stephen M.

“…Background Intrahepatic expression of dipeptidyl peptidase‐4 (DPP4), and circulating DPP4 (cDPP4) levels and its enzymatic activity, are increased in…”
Get full text

The N-Terminal A Domain of Staphylococcus aureus Fibronectin-Binding Protein A Binds to Tropoelastin by Keane, Fiona M, Clarke, Adam W, Foster, Timothy J, Weiss, Anthony S

“…Staphylococcus aureus is an important human pathogen. Its virulence factors include a variety of MSCRAMMs (microbial surface component recognizing adhesive…”
Get full text

Striate Palmoplantar Keratoderma Resulting from Desmoplakin Haploinsufficiency by Whittock, Neil V., Ashton, Gabrielle H.S., Dopping-Hepenstal, Patricia J.C., Gratian, Matthew J., Keane, Fiona M., Eady, Robin A.J., McGrath, John A.

“…Recently, the first example of a human mutation in the gene encoding the desmosomal plaque protein, desmoplakin, has been described in a patient with autosomal…”
Get full text

The influence of contact dermatitis on career change in hairdressers by Laing, Mary E., Powell, Frank C., O'Sullivan, Dorothy, Nagle, Corina M., Keane, Fiona M.

Get full text

Allergy in coronary in-stent restenosis by Keane, Fiona M, Morris, Susie D, Smith, Harvey R, Rycroft, Richard JG

Get full text

NeuropeptideY, B-type natriuretic peptide, substanceP and peptideYY are novel substrates of fibroblast activation protein-[alpha] by Keane, Fiona M, Nadvi, Naveed A, Yao, Tsun-Wen, Gorrell, Mark D

“…Fibroblast activation protein-α (FAP) is a cell surface-expressed and soluble enzyme of the prolyl oligopeptidase family, which includes dipeptidyl peptidase4…”
Get full text

NeuropeptideaY, Batype natriuretic peptide, substanceaP and peptideaYY are novel substrates of fibroblast activation proteinaI by Keane, Fiona M, Nadvi, Naveed A, Yao, TsunaWen, Gorrell, Mark D

“…Fibroblast activation protein- alpha (FAP) is a cell surface-expressed and soluble enzyme of the prolyl oligopeptidase family, which includes dipeptidyl…”
Get full text