Search Results - "Ke, Shizhong"
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1
Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer
Published in Nature communications (10-09-2021)“…Although inhibitors targeting CDK4/6 kinases (CDK4/6i) have shown promising clinical prospect in treating ER+/HER2- breast cancers, acquired drug resistance is…”
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2
Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
Published in Nature communications (15-04-2024)“…Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/C CDH1 ) prevents cell-cycle entry…”
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3
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
Published in Cell (02-09-2021)“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to current therapies attributed to inherent tumor heterogeneity and highly…”
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4
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype
Published in Cell reports (Cambridge) (11-10-2022)“…Poly(ADP)ribosylation inhibitors (PARPis) are toxic to cancer cells with homologous recombination (HR) deficiency but not to HR-proficient cells in the tumor…”
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5
Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations
Published in Hepatology (Baltimore, Md.) (01-01-2017)“…Erythrocytosis is a common paraneoplastic syndrome associated with hepatocellular carcinoma. Although increased erythropoietin (EPO) is found in these…”
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Journal Article -
6
Reciprocal antagonism of PIN1-APC/C CDH1 governs mitotic protein stability and cell cycle entry
Published in Nature communications (15-04-2024)“…Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/C ) prevents cell-cycle entry by…”
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Journal Article -
7
Study of a single airport ground-holding model
Published in Proceedings of the 2003 IEEE International Conference on Intelligent Transportation Systems (2003)“…Ground-holding is an important method to cater for the predicted capacity problem, its purpose is to low the cost of congestion in the air traffic flow…”
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