The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target

Endometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasio...

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Bibliographic Details
Published in:	Biomolecules (Basel, Switzerland) Vol. 11; no. 11; p. 1739
Main Authors:	Ke, Junya, Ye, Jiangfeng, Li, Mingqing, Zhu, Zhiling
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 22-11-2021 MDPI
Subjects:	Angiogenesis Animals Aquaporins Biomarkers - metabolism Calcium Cell adhesion & migration Contaminants Cytokines Endometriosis Endometriosis - enzymology Endometriosis - metabolism Endometriosis - pathology Endometrium Enzymes Estrogens Extracellular matrix Female Fibrosis function Gene expression Glycoproteins Humans Kinases Matrix metalloproteinase matrix metalloproteinases Matrix Metalloproteinases - metabolism MicroRNAs Oxidative stress PCB Peptides Polychlorinated biphenyls potential value Proteins Review Stroma Transplants & implants Uterus endometriosis potential value matrix metalloproteinases function
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Summary:	Endometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasion. The MMP family includes calcium-dependent zinc-containing endopeptidases, some of which not only affect the process of cell invasion but also participate in other physiological and pathological processes, such as angiogenesis and fibrosis. MMPs act as downstream-targeted molecules and their expression can be regulated by numerous factors such as estrogen, oxidative stress, cytokines, and environmental contaminants. Given their unique roles in endometriosis, MMPs may become effective biomarkers of endometriosis in the future. In the present review, we summarize the current literature on MMPs regarding their classification, function, and potential value for endometriosis, which may contribute to our knowledge of MMPs and MMP-targeted interventions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2218-273X 2218-273X
DOI:	10.3390/biom11111739