Search Results - "Kazuyuki Tobe"

Implications of altered NAD metabolism in metabolic disorders by Okabe, Keisuke, Yaku, Keisuke, Tobe, Kazuyuki, Nakagawa, Takashi

“…Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in various energy metabolism pathways, including glycolysis, β-oxidation,…”
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The gut microbiome: a core regulator of metabolism by Fujisaka, Shiho, Watanabe, Yoshiyuki, Tobe, Kazuyuki

“…The human body is inhabited by numerous bacteria, fungi, and viruses, and each part has a unique microbial community structure. The gastrointestinal tract…”
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Japanese Clinical Practice Guideline for Diabetes 2019 by Araki, Eiichi, Goto, Atsushi, Kondo, Tatsuya, Noda, Mitsuhiko, Noto, Hiroshi, Origasa, Hideki, Osawa, Haruhiko, Taguchi, Akihiko, Tanizawa, Yukio, Tobe, Kazuyuki, Yoshioka, Narihito

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Japanese Clinical Practice Guideline for Diabetes 2019 by Araki, Eiichi, Goto, Atsushi, Kondo, Tatsuya, Noda, Mitsuhiko, Noto, Hiroshi, Origasa, Hideki, Osawa, Haruhiko, Taguchi, Akihiko, Tanizawa, Yukio, Tobe, Kazuyuki, Yoshioka, Narihito

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Astaxanthin as a Novel Mitochondrial Regulator: A New Aspect of Carotenoids, beyond Antioxidants by Nishida, Yasuhiro, Nawaz, Allah, Hecht, Karen, Tobe, Kazuyuki

“…Astaxanthin is a member of the carotenoid family that is found abundantly in marine organisms, and has been gaining attention in recent years due to its varied…”
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Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis by Kado, Tomonobu, Nawaz, Allah, Takikawa, Akiko, Usui, Isao, Tobe, Kazuyuki

“…Obesity increases the risk of cancer. Increased levels of hormones (such as oestrogen, insulin, insulin-like growth factor, and leptin), free fatty…”
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M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue by Nawaz, Allah, Tobe, Kazuyuki

“…Adipose tissue (AT) is composed not only of adipocytes, but also of macrophages, endothelial cells and preadipocytes. Macrophages are an important component of…”
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The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis by Kobayashi, Masatoshi, Ohsugi, Mitsuru, Sasako, Takayoshi, Awazawa, Motoharu, Umehara, Toshihiro, Iwane, Aya, Kobayashi, Naoki, Okazaki, Yukiko, Kubota, Naoto, Suzuki, Ryo, Waki, Hironori, Horiuchi, Keiko, Hamakubo, Takao, Kodama, Tatsuhiko, Aoe, Seiichiro, Tobe, Kazuyuki, Kadowaki, Takashi, Ueki, Kohjiro

“…Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be…”
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SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice by Yoon, Myeong Jin, Yoshida, Mitsukuni, Johnson, Sean, Takikawa, Akiko, Usui, Isao, Tobe, Kazuyuki, Nakagawa, Takashi, Yoshino, Jun, Imai, Shin-ichiro

“…Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD+ biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in…”
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Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism by Sasako, Takayoshi, Ohsugi, Mitsuru, Kubota, Naoto, Itoh, Shinsuke, Okazaki, Yukiko, Terai, Ai, Kubota, Tetsuya, Yamashita, Satoshi, Nakatsukasa, Kunio, Kamura, Takumi, Iwayama, Kaito, Tokuyama, Kumpei, Kiyonari, Hiroshi, Furuta, Yasuhide, Shibahara, Junji, Fukayama, Masashi, Enooku, Kenichiro, Okushin, Kazuya, Tsutsumi, Takeya, Tateishi, Ryosuke, Tobe, Kazuyuki, Asahara, Hiroshi, Koike, Kazuhiko, Kadowaki, Takashi, Ueki, Kohjiro

“…Dynamic metabolic changes occur in the liver during the transition between fasting and feeding. Here we show that transient ER stress responses in the liver…”
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History and future perspectives of adipose tissue macrophage biology by Kado, Tomonobu, Nishimura, Ayumi, Tobe, Kazuyuki

“…Macrophages contribute to adipose tissue homeostasis; however, they are also thought to be responsible for insulin resistance in obesity. Macrophages, which…”
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Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene by Mukohira, Hisa, Hara, Takahiro, Abe, Shinya, Tani-Ichi, Shizue, Sehara-Fujisawa, Atsuko, Nagasawa, Takashi, Tobe, Kazuyuki, Ikuta, Koichi

“…Stromal cells in bone marrow (BM) constitute a specific microenvironment supporting the development and maintenance of hematopoietic cells. Adiponectin is a…”
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Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: subgroup analysis of a 3-year post-marketing surveillance study (STELLA–LONG TERM) by Tobe, Kazuyuki, Maegawa, Hiroshi, Nakamura, Ichiro, Uno, Satoshi

“…The STELLA-LONG TERM prospective post-marketing surveillance study assessed ipragliflozin in Japanese patients with type 2 diabetes mellitus (T2DM). This…”
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Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: a subgroup analysis of the STELLA-LONG TERM study (3-month interim results) by Tabuchi, Hiromi, Maegawa, Hiroshi, Tobe, Kazuyuki, Nakamura, Ichiro, Uno, Satoshi

“…This subgroup analysis of STELLA-LONG TERM, an ongoing 3-year post-marketing surveillance study on the long-term efficacy and safety of ipragliflozin, assessed…”
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Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice by FUJISAKA, Shiho, USUI, Isao, KOBAYASHI, Masashi, TOBE, Kazuyuki, BUKHARI, Agussalim, IKUTANI, Masashi, OYA, Takeshi, KANATANI, Yukiko, TSUNEYAMA, Koichi, NAGAI, Yoshinori, TAKATSU, Kiyoshi, URAKAZE, Masaharu

“…Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice Shiho Fujisaka 1 , Isao Usui 1 , Agussalim Bukhari 1 , Masashi…”
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CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors by Nawaz, Allah, Aminuddin, Aminuddin, Kado, Tomonobu, Takikawa, Akiko, Yamamoto, Seiji, Tsuneyama, Koichi, Igarashi, Yoshiko, Ikutani, Masashi, Nishida, Yasuhiro, Nagai, Yoshinori, Takatsu, Kiyoshi, Imura, Johji, Sasahara, Masakiyo, Okazaki, Yukiko, Ueki, Kohjiro, Okamura, Tadashi, Tokuyama, Kumpei, Ando, Akira, Matsumoto, Michihiro, Mori, Hisashi, Nakagawa, Takashi, Kobayashi, Norihiko, Saeki, Kumiko, Usui, Isao, Fujisaka, Shiho, Tobe, Kazuyuki

“…Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting…”
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Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity by Fujisaka, Shiho, Usui, Isao, Nawaz, Allah, Igarashi, Yoshiko, Okabe, Keisuke, Furusawa, Yukihiro, Watanabe, Shiro, Yamamoto, Seiji, Sasahara, Masakiyo, Watanabe, Yoshiyuki, Nagai, Yoshinori, Yagi, Kunimasa, Nakagawa, Takashi, Tobe, Kazuyuki

“…Obesity and insulin resistance are associated with dysbiosis of the gut microbiota and impaired intestinal barrier function. Herein, we report that…”
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Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway by Nishida, Yasuhiro, Nawaz, Allah, Kado, Tomonobu, Takikawa, Akiko, Igarashi, Yoshiko, Onogi, Yasuhiro, Wada, Tsutomu, Sasaoka, Toshiyasu, Yamamoto, Seiji, Sasahara, Masakiyo, Imura, Johji, Tokuyama, Kumpei, Usui, Isao, Nakagawa, Takashi, Fujisaka, Shiho, Kunimasa, Yagi, Tobe, Kazuyuki

“…Background Skeletal muscle is mainly responsible for insulin‐stimulated glucose disposal. Dysfunction in skeletal muscle metabolism especially during obesity…”
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CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model by Ono, Yosuke, Yoshino, Osamu, Hiraoka, Takehiro, Sato, Erina, Furue, Akiko, Nawaz, Allah, Hatta, Hideki, Fukushi, Yoshiyuki, Wada, Shinichiro, Tobe, Kazuyuki, Hirota, Yasushi, Osuga, Yutaka, Unno, Nobuya, Saito, Shigeru

“…In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type…”
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N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis by Kawataka, Masatoshi, Ouhara, Kazuhisa, Kobayashi, Eiji, Shinoda, Koichiro, Tobe, Kazuyuki, Fujimori, Ryousuke, Mizuno, Noriyoshi, Sugiyama, Eiji, Ozawa, Tatsuhiko, Kishi, Hiroyuki

“…Abstract Objectives The variable region of most ACPA IgG molecules in the serum of RA patients carries N-glycan (N-glycanV). To analyse the pathogenicity of…”
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