Search Results - "Kazuko Kamiyama"

β-Hydroxybutyrate enhances the cytotoxic effect of cisplatin via the inhibition of HDAC/survivin axis in human hepatocellular carcinoma cells by Mikami, Daisuke, Kobayashi, Mamiko, Uwada, Junsuke, Yazawa, Takashi, Kamiyama, Kazuko, Nishimori, Kazuhisa, Nishikawa, Yudai, Nishikawa, Sho, Yokoi, Seiji, Taniguchi, Takanobu, Iwano, Masayuki

“…Ketone bodies, including acetoacetate and β-hydroxybutyrate (βOHB), are produced from acetyl coenzyme A in the liver and then secreted into the blood. These…”
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Dichloroacetate reduces cisplatin-induced apoptosis by inhibiting the JNK/14-3-3/Bax/caspase-9 pathway and suppressing caspase-8 activation via cFLIP in murine tubular cells by Kimura, Hideki, Kamiyama, Kazuko, Imamoto, Toru, Takeda, Izumi, Kobayashi, Mamiko, Takahashi, Naoki, Kasuno, Kenji, Sugaya, Takeshi, Iwano, Masayuki

“…Cisplatin-induced injury to renal proximal tubular cells stems from mitochondrial damage-induced apoptosis and inflammation. Dichloroacetate (DCA), a pyruvate…”
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Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways by Mikami, Daisuke, Kobayashi, Mamiko, Uwada, Junsuke, Yazawa, Takashi, Kamiyama, Kazuko, Nishimori, Kazuhisa, Nishikawa, Yudai, Nishikawa, Sho, Yokoi, Seiji, Kimura, Hideki, Kimura, Ikuo, Taniguchi, Takanobu, Iwano, Masayuki

“…Short-chain fatty acids (SCFAs), including acetate, butyrate, and propionate, are produced when colonic bacteria in the human gastrointestinal tract ferment…”
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Chronic hypoxia exacerbates diabetic glomerulosclerosis through mesangiolysis and podocyte injury in db/db mice by Takahashi, Naoki, Yoshida, Haruyoshi, Kimura, Hideki, Kamiyama, Kazuko, Kurose, Tomomi, Sugimoto, Hidehiro, Imura, Toshio, Yokoi, Seiji, Mikami, Daisuke, Kasuno, Kenji, Kurosawa, Hiroyuki, Hirayama, Yoshiaki, Naiki, Hironobu, Hara, Masanori, Iwano, Masayuki

“…Abstract Background Chronic hypoxia may play a pivotal role in the development of diabetic nephropathy (DN). However, the precise mechanisms underlying…”
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A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells by Kobayashi, Mamiko, Mikami, Daisuke, Uwada, Junsuke, Yazawa, Takashi, Kamiyama, Kazuko, Kimura, Hideki, Taniguchi, Takanobu, Iwano, Masayuki

“…Short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate are generated by microbial fermentation of indigestible fiber by gut flora. SCFAs are…”
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PPAR-δ activation reduces cisplatin-induced apoptosis via inhibiting p53/Bax/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells by Shan, Juanping, Kimura, Hideki, Yokoi, Seiji, Kamiyama, Kazuko, Imamoto, Toru, Takeda, Izumi, Kobayashi, Mamiko, Mikami, Daisuke, Takahashi, Naoki, Kasuno, Kenji, Sugaya, Takeshi, Iwano, Masayuki

“…Background Cisplatin-induced injury of renal proximal tubular cells results basically from increased apoptosis via mitochondrial damage, and is mitigated by…”
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AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition by Mikami, Daisuke, Kobayashi, Mamiko, Uwada, Junsuke, Yazawa, Takashi, Kamiyama, Kazuko, Nishimori, Kazuhisa, Nishikawa, Yudai, Nishikawa, Sho, Yokoi, Seiji, Taniguchi, Takanobu, Iwano, Masayuki

“…Background: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide and establishment of new chemotherapies for HCC is urgently needed. GPR41…”
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PPAR-α Insufficiency Enhances Doxorubicin-Induced Nephropathy in PPAR-α Knockout Mice and a Murine Podocyte Cell Line by Matsuta, Kohei, Kamiyama, Kazuko, Imamoto, Toru, Takeda, Izumi, Masunaga, Shinya, Kobayashi, Mamiko, Takahashi, Naoki, Kasuno, Kenji, Hara, Masanori, Iwano, Masayuki, Toyama, Tadashi, Kimura, Hideki

“…Peroxisome proliferator-activated receptor-alpha (PPAR-α) and its exogenous activators (fibrates) promote autophagy. However, whether the deleterious effects…”
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Telmisartan activates endogenous peroxisome proliferator-activated receptor-δ and may have anti-fibrotic effects in human mesangial cells by Mikami, Daisuke, Kimura, Hideki, Kamiyama, Kazuko, Torii, Kunio, Kasuno, Kenji, Takahashi, Naoki, Yoshida, Haruyoshi, Iwano, Masayuki

“…Telmisartan, an angiotensin II receptor type 1 blocker (ARB), was recently reported to promote lipolysis in mice by acting as a peroxisome…”
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Fenofibrate reduces cisplatin-induced apoptosis by inhibiting the p53/Puma/Caspase-9 pathway and the MAPK/Caspase-8 pathway rather than by promoting autophagy in murine renal proximal tubular cells by Kimura, Hideki, Kamiyama, Kazuko, Imamoto, Toru, Takeda, Izumi, Masunaga, Shinya, Kobayashi, Mamiko, Mikami, Daisuke, Takahashi, Naoki, Kasuno, Kenji, Sugaya, Takeshi, Iwano, Masayuki

“…The main lesion of cisplatin nephrotoxicity is damage to proximal tubular cells due to increased apoptosis via the mitochondrial and death receptor pathways,…”
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Glucocorticoid enhances hypoxia- and/or transforming growth factor-β-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells by Kimura, Hideki, Li, Xuan, Torii, Kunio, Okada, Toshiharu, Kamiyama, Kazuko, Mikami, Daisuke, Kasuno, Kenji, Takahashi, Naoki, Yoshida, Haruyoshi

“…Background Glucocorticoid (GC) treatment reportedly exaggerates renal fibrosis in progressive kidney diseases during which hypoxia occurs as an unavoidable…”
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Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells by Kobayashi, Mamiko, Mikami, Daisuke, Kimura, Hideki, Kamiyama, Kazuko, Morikawa, Yukie, Yokoi, Seiji, Kasuno, Kenji, Takahashi, Naoki, Taniguchi, Takanobu, Iwano, Masayuki

“…Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are produced predominantly by gut microbiota fermentation of dietary fiber. SCFAs…”
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β-Hydroxybutyrate, a ketone body, reduces the cytotoxic effect of cisplatin via activation of HDAC5 in human renal cortical epithelial cells by Mikami, Daisuke, Kobayashi, Mamiko, Uwada, Junsuke, Yazawa, Takashi, Kamiyama, Kazuko, Nishimori, Kazuhisa, Nishikawa, Yudai, Morikawa, Yukie, Yokoi, Seiji, Takahashi, Naoki, Kasuno, Kenji, Taniguchi, Takanobu, Iwano, Masayuki

“…β-Hydroxybutyrate (βOHB) is a metabolic intermediate that constitutes about 70% of ketone bodies produced in liver from oxidation of fatty acids released from…”
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Severe Diabetic Glomerulosclerosis by Chronic Hypoxic Housing of db/db Mice: The Role of Mesangiolysis and Podocyte Injury: PO0933 by Takahashi, Naoki, Yoshida, Haruyoshi, Kimura, Hideki, Kamiyama, Kazuko, Yokoi, Seiji, Kasuno, Kenji, Kurosawa, Hiroyuki, Hirayama, Yoshiaki, Hara, Masanori, Iwano, Masayuki

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Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis by Morikawa, Yukie, Takahashi, Naoki, Kamiyama, Kazuko, Nishimori, Kazuhisa, Nishikawa, Yudai, Morita, Sayu, Kobayashi, Mamiko, Fukushima, Sachiko, Yokoi, Seiji, Mikami, Daisuke, Kimura, Hideki, Kasuno, Kenji, Yashiki, Tetsuya, Naiki, Hironobu, Hara, Masanori, Iwano, Masayuki

“…Extracellular vesicles (EVs), including exosomes, are present in various bodily fluids, including urine. We and others previously reported that cells…”
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Telmisartan, a possible PPAR-δ agonist, reduces TNF-α-stimulated VEGF-C production by inhibiting the p38MAPK/HSP27 pathway in human proximal renal tubular cells by Kimura, Hideki, Mikami, Daisuke, Kamiyama, Kazuko, Sugimoto, Hidehiro, Kasuno, Kenji, Takahashi, Naoki, Yoshida, Haruyoshi, Iwano, Masayuki

“…•TNF-α increased VEGF-C expression by enhancing phosphorylation of p38MAPK and HSP27.•Telmisartan decreased TNF-α-stimulated expression of VEGF-C.•Telmisartan…”
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AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis HDAC inhibition by Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, Takashi Yazawa, Kazuko Kamiyama, Kazuhisa Nishimori, Yudai Nishikawa, Sho Nishikawa, Seiji Yokoi, Takanobu Taniguchi, Masayuki Iwano

“…Background: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide and establishment of new chemotherapies for HCC is urgently needed. GPR41…”
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Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association by Shimada, Akihiro, Kimura, Hideki, Oida, Koji, Kanehara, Hideo, Bando, Yukihiro, Sakamoto, Shinobu, Wakasugi, Takanobu, Saga, Takashi, Ito, Yasuki, Kamiyama, Kazuko, Mikami, Daisuke, Iwano, Masayuki, Hirano, Tsutomu, Yoshida, Haruyoshi

“…Statins decrease cholesteryl ester transfer protein (CETP) levels, which have been positively associated with hepatic lipid content as well as serum low…”
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Dexamethasone enhances basal and TNF-α-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11β-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells by Kimura, Hideki, Li, Xuan, Torii, Kunio, Okada, Toshiharu, Kamiyama, Kazuko, Mikami, Daisuke, Takahashi, Naoki, Yoshida, Haruyoshi

“…Background. Long-term treatment with glucocorticoids (GCs) reportedly exaggerates renal fibrosis in chronic progressive inflammatory kidney disease. GCs induce…”
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Dexamethasone enhances basal and TNF-[alpha]-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11[beta]-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells by Kimura, Hideki, Li, Xuan, Torii, Kunio, Okada, Toshiharu, Kamiyama, Kazuko, Mikami, Daisuke, Takahashi, Naoki, Yoshida, Haruyoshi

“…Background. Long-term treatment with glucocorticoids (GCs) reportedly exaggerates renal fibrosis in chronic progressive inflammatory kidney disease. GCs induce…”
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