Search Results - "Kazuhiro Takekoshi"

One Week of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver by Sugasawa, Takehito, Ono, Seiko, Yonamine, Masato, Fujita, Shin-ichiro, Matsumoto, Yuki, Aoki, Kai, Nakano, Takuro, Tamai, Shinsuke, Yoshida, Yasuko, Kawakami, Yasushi, Takekoshi, Kazuhiro

“…The prevalence of nonalcoholic fatty liver disease (NAFLD) has been rapidly increasing worldwide. A choline-deficient, L-amino acid-defined, high-fat diet…”
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Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle by Misu, Hirofumi, Takayama, Hiroaki, Saito, Yoshiro, Mita, Yuichiro, Kikuchi, Akihiro, Ishii, Kiyo-aki, Chikamoto, Keita, Kanamori, Takehiro, Tajima, Natsumi, Lan, Fei, Takeshita, Yumie, Honda, Masao, Tanaka, Mutsumi, Kato, Seiji, Matsuyama, Naoto, Yoshioka, Yuya, Iwayama, Kaito, Tokuyama, Kumpei, Akazawa, Nobuhiko, Maeda, Seiji, Takekoshi, Kazuhiro, Matsugo, Seiichi, Noguchi, Noriko, Kaneko, Shuichi, Takamura, Toshinari

“…Selenoprotein P is released from the liver and acts through LRP1 in the muscle to contribute to exercise resistance in mouse and man by inhibiting ROS levels…”
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Risk Stratification on Pheochromocytoma and Paraganglioma from Laboratory and Clinical Medicine by Kimura, Noriko, Takekoshi, Kazuhiro, Naruse, Mitsuhide

“…Pheochromocytoma (PCC) and sympathetic paraganglioma (PGL) are rare neuroendocrine tumors characterized by catecholamine production in the adrenal medulla and…”
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Efficacy and safety of metyrosine in pheochromocytoma/paraganglioma: a multi-center trial in Japan by Naruse, Mitsuhide, Satoh, Fumitoshi, Tanabe, Akiyo, Okamoto, Takahiro, Ichihara, Atsuhiro, Tsuiki, Mika, Katabami, Takuyuki, Nomura, Masatoshi, Tanaka, Tomoaki, Matsuda, Tadashi, Imai, Tsuneo, Yamada, Masanobu, Harada, Tomohiro, Kawata, Nobuyuki, Takekoshi, Kazuhiro

“…To assess the efficacy, safety, and pharmacokinetics of metyrosine (an inhibitor of catecholamine synthesis) in patients with pheochromocytoma/paraganglioma…”
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Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas by Kimura, Noriko, Shiga, Kiyoto, Kaneko, Ken-ichi, Oki, Yutaka, Sugisawa, Chiho, Saito, Jun, Tawara, Seiich, Akahori, Hiroshi, Sogabe, Susumu, Yamashita, Takafumi, Takekoshi, Kazuhiro, Naruse, Mitsuhide, Katabami, Takayuki

“…Paragangliomas (PGLs) are neural-crest-derived, non-epithelial neuroendocrine tumors distributed along the parasympathetic and sympathetic nerves…”
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Longest survival by the combination of radiation-therapy and resection in patient with metastatic spinal paragangliomas from primary-neck lesion with succinate dehydrogenase subunit B (SDHB) mutation by Kitagawa, Takehiro, Ohtonari, Tatsuya, Yamamoto, Junkoh, Nishihara, Nobuharu, Nishigaki, Masakazu, Takekoshi, Kazuhiro

“…Metastatic paraganglioma (MPG) of the spine is a rare condition, with no established management. Herein, we report the longest survival case of a primary neck…”
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Gene Expression Profile Provides Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle by Sugasawa, Takehito, Komine, Ritsuko, Manevich, Lev, Tamai, Shinsuke, Takekoshi, Kazuhiro, Kanki, Yasuharu

“…Recently, fasting has been spotlighted from a healthcare perspective. However, the de-tailed biological mechanisms and significance by which the effects of…”
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Xanthine Oxidoreductase Activity in Marathon Runners: Potential Implications for Marathon-Induced Acute Kidney Injury by Kosaki, Keisei, Kumamoto, Shota, Tokinoya, Katsuyuki, Yoshida, Yasuko, Sugaya, Takeshi, Murase, Takayo, Akari, Seigo, Nakamura, Takashi, Nabekura, Yoshiharu, Takekoshi, Kazuhiro, Maeda, Seiji

“…Excess activation of circulating xanthine oxidoreductase (XOR) may contribute to the pathogenesis of widespread remote organ injury, including kidney injury…”
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Long-Term Habitual Exercise and Combination of β-Hydroxy-β-Methylbutyrate plus Black Ginger Alter the Autophagy and Mitochondria Related Genes in SAMP8 Mice by AOKI, Kai, KONNO, Masaki, TOKINOYA, Katsuyuki, HONDA, Katsunari, ABE, Takuya, NAGATA, Takeshi, TAKEHARA, Masaaki, SUGASAWA, Takehito, TAKEKOSHI, Kazuhiro, OHMORI, Hajime

“…Muscle mass and strength decrease with aging; however, habitual exercise can maintain muscle health. β-Hydroxy-β-methyl butyrate calcium (HMB) and black ginger…”
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A case of adrenaline-predominant paraganglioma diagnosed with a state of shock after glucagon injection by Nakama, Hiroshi, Okamoto, Mitsuhiro, Kurosawa, Keiko, Mimata, Hiromitsu, Daa, Tsutom, Takekoshi, Kazuhiro, Gotoh, Koro, Masaki, Takayuki, Shibata, Hirotaka

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High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways by Mehrazad Saber, Zahra, Takeuchi, Yoshinori, Sawada, Yoshikazu, Aita, Yuichi, Ho, Man Hei, Karkoutly, Samia, Tao, Duhan, Katabami, Kyoka, Ye, Chen, Murayama, Yuki, Shikama, Akito, Masuda, Yukari, Izumida, Yoshihiko, Miyamoto, Takafumi, Matsuzaka, Takashi, Sugasawa, Takehito, Takekoshi, Kazuhiro, Kawakami, Yasushi, Shimano, Hitoshi, Yahagi, Naoya

“…High protein diet (HPD) is an affordable and positive approach in prevention and treatment of many diseases. It is believed that transcriptional regulation is…”
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Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice by Yanazawa, Koki, Sugasawa, Takehito, Aoki, Kai, Nakano, Takuro, Kawakami, Yasushi, Takekoshi, Kazuhiro

“…Gene doping is the misuse of genome editing and gene therapy technologies for the purpose of manipulating specific genes or gene functions in order to improve…”
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Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice by Aoki, Kai, Suzuki, Takuji, Hui, Fang, Nakano, Takuro, Yanazawa, Koki, Yonamine, Masato, Fujita, Shinichiro, Sugasawa, Takehito, Yoshida, Yasuko, Omi, Naomi, Kawakami, Yasushi, Takekoshi, Kazuhiro

“…The effects of exercise on nutrient digestion and absorption in the intestinal tract are not well understood. A few studies have reported that exercise…”
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Denervation‐induced muscle atrophy suppression in renalase‐deficient mice via increased protein synthesis by Tokinoya, Katsuyuki, Shirai, Takanaga, Ota, Yuya, Takemasa, Tohru, Takekoshi, Kazuhiro

“…Denervation‐induced muscle atrophy increases signaling through both protein degradation and synthesis pathways. Renalase is a flavin adenine…”
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Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization by Saito, Yuria, Ishii, Kiyo-aki, Aita, Yuichi, Ikeda, Tatsuhiko, Kawakami, Yasushi, Shimano, Hitoshi, Hara, Hisato, Takekoshi, Kazuhiro

“…Germline mutations in genes encoding succinate dehydrogenase subunits are associated with the development of familial pheochromocytomas and paragangliomas…”
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Inhibition of Autophagy Enhances Sunitinib-Induced Cytotoxicity in Rat Pheochromocytoma PC12 cells by Ikeda, Tatsuhiko, Ishii, Kiyo-aki, Saito, Yuria, Miura, Masahiro, Otagiri, Aoi, Kawakami, Yasushi, Shimano, Hitoshi, Hara, Hisato, Takekoshi, Kazuhiro

“…Sunitinib is an oral multitargeted receptor tyrosine kinase inhibitor with antiangiogenic and antitumor activity that mainly targets vascular endothelial…”
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Variabilities of salivary human herpesvirus 6/7 and cortisol levels during a three-day training camp in judo athletes by Tamai, Shinsuke, Hiraoka, Hiroaki, Shimizu, Kazuhiro, Miyake, Keisuke, Hoshi, Daisuke, Aoki, Kai, Yanazawa, Koki, Sugasawa, Takehito, Takekoshi, Kazuhiro, Watanabe, Koichi

“…Physical fatigue accompanying athletic training has been a problem for ages. While salivary cortisol has traditionally been used to assess physical stressors,…”
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High Salt Diet Impacts the Risk of Sarcopenia Associated with Reduction of Skeletal Muscle Performance in the Japanese Population by Yoshida, Yasuko, Kosaki, Keisei, Sugasawa, Takehito, Matsui, Masahiro, Yoshioka, Masaki, Aoki, Kai, Kuji, Tomoaki, Mizuno, Risuke, Kuro-O, Makoto, Yamagata, Kunihiro, Maeda, Seiji, Takekoshi, Kazuhiro

“…The World Health Organization has recommended 5 g/day as dietary reference intakes for salt. In Japan, the averages for men and women were 11.0 g/day and 9.3…”
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Effect of acute moderate-intensity cycling on cfDNA levels considering menstrual cycle phases by Sawai, Akemi, Shida, Takashi, Hoshikawa, Yoshihiro, Hatanaka, Sho, Ueda, Mashiro, Kato, Yuri, Tokinoya, Katsuyuki, Natsui, Hiroaki, Kawakami, Yasushi, Takekoshi, Kazuhiro

“…We aimed to determine the effects of exercise on cell-free DNA (cfDNA) levels and concentration changes during the menstrual cycle in participants with regular…”
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Correlation between urinary fractionated metanephrines in 24-hour and spot urine samples for evaluating the therapeutic effect of metyrosine: a subanalysis of a multicenter, open-label phase I/II study by Takekoshi, Kazuhiro, Satoh, Fumitoshi, Tanabe, Akiyo, Okamoto, Takahiro, Ichihara, Atsuhiro, Tsuiki, Mika, Katabami, Takuyuki, Nomura, Masatoshi, Tanaka, Tomoaki, Matsuda, Tadashi, Imai, Tsuneo, Yamada, Masanobu, Asada, Suguru, Kawata, Nobuyuki, Naruse, Mitsuhide

“…We recently conducted an open-label phase I/II study to evaluate the efficacy and safety of preoperative and chronic treatment with metyrosine (an inhibitor of…”
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