Search Results - "Kazuhiro Onuma"

Local Joint Inflammation and Histone Citrullination in a Murine Model of the Transition From Preclinical Autoimmunity to Inflammatory Arthritis by Sohn, Dong Hyun, Rhodes, Christopher, Onuma, Kazuhiro, Zhao, Xiaoyan, Sharpe, Orr, Gazitt, Tal, Shiao, Rani, Fert‐Bober, Justyna, Cheng, Danye, Lahey, Lauren J., Wong, Heidi H., Van Eyk, Jennifer, Robinson, William H., Sokolove, Jeremy

“…Objective Anti–citrullinated protein antibodies (ACPAs) are characteristic of rheumatoid arthritis (RA). However, their presence years before the onset of…”
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Evaluation of ocular biometry in the Japanese population using a multicenter approach: Prospective observational study by Kawamorita, Takushi, Uozato, Hiroshi, Oshika, Tetsuro, Negishi, Kazuno, Fujikado, Takashi, Murakami, Akira, Kamiya, Kazutaka, Maeda, Naoyuki, Ueno, Yuta, Onuma, Kazuhiro, Hirota, Masakazu, Hoshikawa, Rie, Masui, Sachiko, Yamaguchi, Masahiro, Mihashi, Toshifumi

“…This prospective observational study aimed to evaluate the ocular biometry of Japanese people through a multicenter approach. The uncorrected and corrected…”
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Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model by Kaseda, Shota, Sannomiya, Yuya, Horizono, Jun, Kuwazuru, Jun, Suico, Mary Ann, Ogi, Sayaka, Sasaki, Ryoko, Sunamoto, Hidetoshi, Fukiya, Hirohiko, Nishiyama, Hayato, Kamura, Misato, Niinou, Saki, Koyama, Yuimi, Nara, Futoshi, Shuto, Tsuyoshi, Onuma, Kazuhiro, Kai, Hirofumi

“…Background Bardoxolone methyl activates nuclear factor erythroid 2–related factor 2 (Nrf2) via covalent binding and irreversible inhibition of Kelch-like…”
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Efficacy of Keap1-Nrf2 protein-protein interaction inhibitor for progressive phenotype in Alport syndrome mouse model by Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Saki Niinou, Yuimi Koyama, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai

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Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis by Kragstrup, Tue W, Sohn, Dong H, Lepus, Christin M, Onuma, Kazuhiro, Wang, Qian, Robinson, William H, Sokolove, Jeremy

“…The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Tissue repair responses include transforming growth…”
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EX-10. Efficacy of Keap1-Nrf2 protein-protein interaction inhibitor for progressive phenotype in Alport syndrome mouse model by Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Saki Niinou, Suico Mary Ann, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai

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MO578: UBE-1099, A Novel Non-Covalent Keap1-NRF2 Inhibitor, Protects Against Renal Ischemia-Reperfusion Injury by Ogi, Sayaka, Sunamoto, Hidetoshi, Fukiya, Hirohiko, Nara, Futoshi, Onuma, Kazuhiro

“…Abstract BACKGROUND AND AIMS Bardoxolone methyl is a covalent Kelch-like ECH-associated protein 1 (Keap1) inhibitor that induces nuclear factor erythroid…”
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UBE-1099, a Novel Non-Covalent Keap1-Nrf2 Inhibitor, Protects Against Renal Ischemia-Reperfusion Injury via Nrf2 Activation: PO2508 by Ogi, Sayaka, Sunamoto, Hidetoshi, Fukiya, Hirohiko, Nara, Futoshi, Onuma, Kazuhiro

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Bardoxolone methyl prevents metabolic dysfunction‐associated steatohepatitis by inhibiting macrophage infiltration by Onuma, Kazuhiro, Watanabe, Kenji, Isayama, Keishiro, Ogi, Sayaka, Tokunaga, Yasunori, Mizukami, Yoichi

“…Background and Purpose Bardoxolone methyl (2‐cyano‐3,12‐dioxooleana‐1,9(11)‐dien‐28‐oic acid methyl ester, CDDO‐Me) is a potent activator of nuclear factor…”
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Novel Keap-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates the Severity of Experimental Alport Syndrome: PO1302 by Kaseda, Shota, Suico, Mary Ann, Ogi, Sayaka, Sunamoto, Hidetoshi, Fukiya, Hirohiko, Nara, Futoshi, Shuto, Tsuyoshi, Onuma, Kazuhiro, Kai, Hirofumi

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Effect of partially hydrolyzed guar gum on the expression of aquaporin‐3 in the colon by Kon, Risako, Ikarashi, Nobutomo, Onuma, Kazuhiro, Yasukawa, Zenta, Ozeki, Makoto, Sakai, Hiroyasu, Kamei, Junzo

“…In recent years, the development of functional foods targeting gastrointestinal disorders has been in progress. Partially hydrolyzed guar gum (PHGG), which is…”
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Preclinical in vitro and in vivo study of UD-017, a novel highly selective and orally available CDK7 inhibitor, in a variety of cancers by Onuma, Kazuhiro, Aga, Yasuhiro, Ogi, Sayaka, Matsushita, Takashi, Sunamoto, Hidetoshi, Ogawa, Ayumi, Tokunaga, Yasunori, Ushiyama, Shigeru

“…Abstract only e14086 Background: Cyclin dependent kinase 7 (CDK7) modulates mRNA transcription and some oncogenes are reported to be sensitive to inhibition of…”
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Abstract 4835: UD-017, a novel highly selective and orally active CDK7 inhibitor, shows a significant anticancer activity in patient-derived cancers by Matsushita, Takashi, Ogi, Sayaka, Onuma, Kazuhiro, Sunamoto, Hidetoshi, Ogawa, Ayumi, Hasegawa, Toru, Tokunaga, Yasunori, Aga, Yasuhiro, Ushiyama, Shigeru

“…Abstract Background: Cyclin dependent kinase 7 (CDK7) is an attractive target for anticancer drugs due to its dual roles, cell cycle regulation and gene…”
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Abstract 4837: Evaluation of anticancer activities of UD-017, a novel selective and orally available CDK7 inhibitor, in blood cancers by Aga, Yasuhiro, Ogi, Sayaka, Onuma, Kazuhiro, Sunamoto, Hidetoshi, Matsushita, Takashi, Ogawa, Ayumi, Hasegawa, toru, Kono, Shigeyuki, Iwase, Noriaki, Ushiyama, Shigeru

“…Abstract Background: Cyclin dependent kinase 7 (CDK7) is an attractive target for anticancer drugs due to its dual roles, cell cycle regulation and gene…”
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Cover Image by Kon, Risako, Ikarashi, Nobutomo, Onuma, Kazuhiro, Yasukawa, Zenta, Ozeki, Makoto, Sakai, Hiroyasu, Kamei, Junzo

“…The cover image is based on the Original Article Effect of partially hydrolyzed guar gum on the expression of aquaporin‐3 in the colon by Risako Kon et al.,…”
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Cover Image by Kon, Risako, Ikarashi, Nobutomo, Onuma, Kazuhiro, Yasukawa, Zenta, Ozeki, Makoto, Sakai, Hiroyasu, Kamei, Junzo

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Cover Image by Kon, Risako, Ikarashi, Nobutomo, Onuma, Kazuhiro, Yasukawa, Zenta, Ozeki, Makoto, Sakai, Hiroyasu, Kamei, Junzo

“…The cover image is based on the Original Article Effect of partially hydrolyzed guar gum on the expression of aquaporin‐3 in the colon by Risako Kon et al.,…”
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Cover Image by Kon, Risako, Ikarashi, Nobutomo, Onuma, Kazuhiro, Yasukawa, Zenta, Ozeki, Makoto, Sakai, Hiroyasu, Kamei, Junzo

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Abstract LB-111: In vitro anti-cancer activity of UD-017, a novel potent & highly selective CDK7 reversible inhibitor by Matsushita, Takashi, Onuma, Kazuhiro, Sunamoto, Hidetoshi, Ogawa, Ayumi, Ogi, Sayaka, Hasegawa, Toru, Kono, Shigeyuki, Iwase, Noriaki, Aga, Yasuhiro, Ushiyama, Shigeru

“…Abstract Background: Cyclin dependent kinase 7 (CDK7) is a member of the CDK family, & has a dual function relating to the cell cycle progression & gene…”
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Abstract LB-297: In vivo anti-tumor efficacy of UD-017, a novel highly selective & orally available CDK7 inhibitor, in colorectal cancer cells xenograft models by Aga, Yasuhiro, Ogi, Sayaka, Tokunaga, Yasunori, Ogawa, Ayumi, Onuma, Kazuhiro, Matsushita, Takashi, Sunamoto, Hidetoshi, Hasegawa, Toru, Ushiyama, Shigeru

“…Abstract Background: Cyclin dependent kinase 7 (CDK7) is an attractive target for cancer drugs due to its dual roles, cell cycle regulation & gene…”
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