Search Results - "Kazmi, Rashid"

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy by Pasi, K. John, Rangarajan, Savita, Georgiev, Pencho, Mant, Tim, Creagh, Michael D, Lissitchkov, Toshko, Bevan, David, Austin, Steve, Hay, Charles R, Hegemann, Inga, Kazmi, Rashid, Chowdary, Pratima, Gercheva-Kyuchukova, Liana, Mamonov, Vasily, Timofeeva, Margarita, Soh, Chang-Heok, Garg, Pushkal, Vaishnaw, Akshay, Akinc, Akin, Sørensen, Benny, Ragni, Margaret V

“…In this phase 1 study, a chemically modified RNA interference therapy designed to target antithrombin was administered to participants with hemophilia A or B…”
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Homeostasis of Hemostasis: The Role of Endothelium by Kazmi, Rashid S, Boyce, Sara, Lwaleed, Bashir A

“…Forming an interface with virtually every other organ, endothelium has a strategic role in modulating vascular homeostasis. While its miscellany of functions…”
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New anticoagulants: how to deal with treatment failure and bleeding complications by Kazmi, Rashid S., Lwaleed, Bashir A.

“…Conventional anticoagulants have proven efficacy in the management of thromboembolism. Their adverse effects and a narrow therapeutic window, necessitating…”
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The Activation of Complement and Its Role in the Pathogenesis of Thromboembolism by Boyce, Sara, Eren, Efrem, Lwaleed, Bashir A, Kazmi, Rashid S

“…It is well established that inflammation and thrombosis are intricately linked processes, and there is increasing evidence of the importance of their roles in…”
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Exploring the natural variation for seedling traits and their link with seed dimensions in tomato by Khan, Noorullah, Kazmi, Rashid H, Willems, Leo A J, van Heusden, Adriaan W, Ligterink, Wilco, Hilhorst, Henk W M

“…The success of germination, growth and final yield of every crop depends to a large extent on the quality of the seeds used to grow the crop. Seed quality is…”
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Educational needs of patients, families, and healthcare professionals to support the patient journey in haemophilia gene therapy in the UK by Boyce, Sara, Fletcher, Simon, Jones, April, Kohli, Ruchika, Mangles, Sarah, Ong, Min, Pollard, Debra, Sivasubramaniyam, Sujan, Stephensen, David, Stoner, Nicola, Kazmi, Rashid

“…Abstract With the first gene therapies for haemophilia approved by the European Commission, the US Food and Drug Administration, and the Medicines and…”
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Metabolomic analysis of tomato seed germination by Kazmi, Rashid H., Willems, Leo A. J., Joosen, Ronny V. L., Khan, Noorullah, Ligterink, Wilco, Hilhorst, Henk W. M.

“…Introduction Seed germination is inherently related to seed metabolism, which changes throughout its maturation, desiccation and germination processes. The…”
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Platelet function in pre-eclampsia by Kazmi, Rashid S, Cooper, Alan J, Lwaleed, Bashir A

“…Pronounced hemostatic changes occur during pregnancy, and the balance shifts markedly in favor of hypercoagulability. Although primarily a result of a marked…”
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Inflammation, Endothelial Dysfunction, and Thromboembolism by Lwaleed, Bashir A, Kazmi, Rashid S, Cooper, Alan J

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Complex genetics controls natural variation among seed quality phenotypes in a recombinant inbred population of an interspecific cross between Solanum lycopersicum × Solanum pimpinellifolium by KAZMI, RASHID H., KHAN, NOORULLAH, WILLEMS, LEO A. J., VAN HEUSDEN, ADRIAAN W., LIGTERINK, WILCO, HILHORST, HENK W. M.

“…ABSTRACT Seed quality in tomato is associated with many complex physiological and genetic traits. While plant processes are frequently controlled by the action…”
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Gastrointestinal Bleeding and Aortic Stenosis (Heyde Syndrome): The Role of Aortic Valve Replacement by Saad, Rasheed A., Lwaleed, Bashir A., Kazmi, Rashid S.

“…Heyde syndrome (the combination of iron deficiency anemia and aortic stenosis) has been a controversial entity. The proposed mechanisms between aortic valve…”
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Sources of thrombomodulin in pre-eclampsia: renal dysfunction or endothelial damage? by Dusse, Luci, Godoi, Lara, Kazmi, Rashid S, Alpoim, Patrícia, Petterson, Juliane, Lwaleed, Bashir A, Carvalho, Maria

“…A plethora of evidence exists to show that endothelial perturbations underlie many of the clinical features of pre-eclampsia (P-EC), and consequently the…”
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Tissue factor and tissue factor pathway inhibitor in women with a past history of preeclampsia: implication for a hypercoagulable state postpregnancy by Lwaleed, Bashir A, Breish, Mohamed O, Birch, Brian R, Chowdhary, Azeem P, Saad, Rasheed A, Perigo, Oliver, Kazmi, Rashid S, Dusse, Luci M, Cooper, Alan J

“…Preeclampsia (P-EC) is a multisystem disorder of pregnancy whose cause and pathogenesis remain poorly understood. However, abnormal haemostasis and endothelial…”
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Elevated plasma factor VIII and von Willebrand factor in women with type 2 diabetes: inflammatory reaction, endothelial perturbation or else? by Soares, Anna L, Kazmi, Rashid S, Borges, Michelle A, Rosário, Pedro W, Fernandes, Ana P, Sousa, Marinez O, Lwaleed, Bashir A, Carvalho, Maria G

“…The association between type 2 diabetes and cardiovascular disease is long recognized. Although perturbations of haemostatic markers have been shown to be…”
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Early identification and prognostic implications in disseminated intravascular coagulation through transmittance waveform analysis by Downey, C, Kazmi, R, Toh, C H

“…Efforts to improve the prognosis in disseminated intravascular coagulation (DIC) have been hampered by the lack of an early, useful and rapidly available…”
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Novel and diagnostically applicable information from optical waveform analysis of blood coagulation in disseminated intravascular coagulation by DOWNEY, COLIN, KAZMI, RASHID, TOH, CHENG HOCK

“…Transmittance waveform is the term applied to the optical profile generated from the process of clot formation on standard coagulation tests run on the…”
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Impaired Fibrinolysis in Angiographically Documented Coronary Artery Disease by Carvalho, Maria das Graças, Kazmi, Rashid Saeed, de Toledo, Vicente de Paulo Coelho Peixoto, Sousa, Marinez Oliveira, Lima, Luciana Moreira, Fernandes, Adriano Basques, Lwaleed, Bashir A.

“…Impaired fibrinolysis may predispose to coronary artery disease (CAD). Hypofibrinolysis due to high levels of plasminogen activator inhibitor-1 (PAI-1) has…”
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Gene Therapy with Etranacogene Dezaparvovec for Hemophilia B by Pipe, Steven W., Leebeek, Frank W.G., Recht, Michael, Key, Nigel S., Castaman, Giancarlo, Miesbach, Wolfgang, Lattimore, Susan, Peerlinck, Kathelijne, Van der Valk, Paul, Coppens, Michiel, Kampmann, Peter, Meijer, Karina, O’Connell, Niamh, Pasi, K. John, Hart, Daniel P., Kazmi, Rashid, Astermark, Jan, Hermans, Cedric R.J.R., Klamroth, Robert, Lemons, Richard, Visweshwar, Nathan, von Drygalski, Annette, Young, Guy, Crary, Shelley E., Escobar, Miguel, Gomez, Esteban, Kruse-Jarres, Rebecca, Quon, Doris V., Symington, Emily, Wang, Michael, Wheeler, Allison P., Gut, Robert, Liu, Ying P., Dolmetsch, Ricardo E., Cooper, David L., Li, Yanyan, Goldstein, Brahm, Monahan, Paul E.

“…An AAV5 vector containing the factor IX Padua allele was administered to 54 men with hemophilia B. Factor IX expression increased to approximately 39% of…”
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Global Seroprevalence of Pre-existing Immunity Against AAV5 and Other AAV Serotypes in People with Hemophilia A by Klamroth, Robert, Hayes, Gregory, Andreeva, Tatiana, Gregg, Keith, Suzuki, Takashi, Mitha, Ismail Haroon, Hardesty, Brandon, Shima, Midori, Pollock, Toni, Slev, Patricia, Oldenburg, Johannes, Ozelo, Margareth C, Stieltjes, Natalie, Castet, Sabine-Marie, Mahlangu, Johnny, Peyvandi, Flora, Kazmi, Rashid, Schved, Jean-François, Leavitt, Andrew D, Callaghan, Michael, Pan-Petesch, Brigitte, Quon, Doris V, Andrews, Jayson, Trinh, Alex, Li, Mingjin, Wong, Wing Yen

“…Adeno-associated virus (AAV)-mediated gene therapy may provide durable protection from bleeding events and reduce treatment burden for people with hemophilia A…”
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Acquired Bernard–Soulier syndrome and hypodysfibrinogenaemia because of multiple myeloma by Sehgal, Tushar, Altohami, Mohammed, Lafferty, Nicholas, Desborough, Michael, Boyce, Sara, Kazmi, Rashid, Jenner, Matthew

“…We describe a case of a patient with multiple myeloma with initial presentation simulating a bleeding disorder. Detailed coagulation work-up showed…”
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