Search Results - "Kazianis, Steven"

Regulation of CDKN2A/B and Retinoblastoma genes in Xiphophorus melanoma by Butler, Andrew P., Trono, David, Coletta, Luis Della, Beard, Rebecca, Fraijo, Rachel, Kazianis, Steven, Nairn, Rodney S.

“…Xiphophorus interspecies hybrids provide several well-characterized genetic models of melanoma susceptibility. The Xiphophorus CDKN2A/B gene, homologous to…”
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Absence of global genomic cytosine methylation pattern erasure during medaka ( Oryzias latipes) early embryo development by Walter, Ronald B., Li, Hai-Ying, Intano, Gabriel W., Kazianis, Steven, Walter, Christi A.

“…Two techniques were used to analyze global genomic 5-methyl cytosine methylation at CCGG sites of medaka embryo DNA. DNA was labeled by incorporation of…”
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A CDKN2-Like Polymorphism in Xiphophorus LG V is Associated with UV-B-Induced Melanoma Formation in Platyfish--Swordtail Hybrids by Nairn, Rodney S., Kazianis, Steven, McEntire, Brenda B., Della Coletta, Luis, Walter, Ronald B., Morizot, Donald C.

“…The genetic basis of spontaneous melanoma formation in spotted dorsal (Sd) Xiphophorus platyfish--swordtail hybrids has been studied for decades, and is…”
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Identification and Mapping of Two Divergent, Unlinked Major Histocompatibility Complex Class II B Genes in Xiphophorus Fishes by McConnell, Thomas J, Godwin, Ulla B, Norton, Stephen F, Nairn, Rodney S, Kazianis, Steven, Morizot, Donald C

“…We have isolated two major histocompatibility complex (MHC) class II B genes from the inbred fish strain Xiphophorus maculatus Jp 163 A. We mapped one of these…”
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Mutant V600E BRAF increases hypoxia inducible factor-1α expression in melanoma by KUMAR, Suresh M, HONG YU, EDWARDS, Robin, LIANJUN CHEN, KAZIANIS, Steven, BRAFFORD, Patricia, ACS, Geza, HERLYN, Meenhard, XIAOWEI XU

“…Abstract Mutations in the BRAF serine/threonine kinase gene are frequently found in cutaneous melanomas. Activation of hypoxia inducible factor-1α (HIF-1α) in…”
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Xiphophorus Interspecies Hybrids as Genetic Models of Induced Neoplasia by Walter, Ronald B., Kazianis, Steven

“…Fishes of the genus Xiphophorus (platyfishes and swordtails) are small, internally fertilizing, livebearing, and derived from freshwater habitats in Mexico,…”
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Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma by Kumar, Suresh M, Yu, Hong, Edwards, Robin, Chen, Lianjun, Kazianis, Steven, Brafford, Patricia, Acs, Geza, Herlyn, Meenhard, Xu, Xiaowei

“…Mutations in the BRAF serine/threonine kinase gene are frequently found in cutaneous melanomas. Activation of hypoxia inducible factor-1alpha (HIF-1alpha) in…”
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Divergent patterns of selection on the DAB and DXB MHC class II loci in Xiphophorus fishes by Summers, Kyle, Roney, Kelly E, da Silva, Jack, Capraro, Gerald, Cuthbertson, Brandon J, Kazianis, Steven, Rosenthal, Gil G, Ryan, Michael J, McConnell, Thomas J

“…Two MHC class II loci, DAB (a classical class II locus) and DXB (putatively a non-classical class II locus), were sequenced in samples of individuals from two…”
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Decreased Levels of (6-4) Photoproduct Excision Repair in Hybrid Fish of the Genus Xiphophorus by Mitchell, David L., Nairn, Rodney S., Johnston, Dennis A., Byrom, Michelle, Kazianis, Steven, Walter, Ronald B.

“…Selected hybridization in the fish genus Xiphophorus has been used for many years to study the genetics of malignant melanoma. Because DNA damage caused by…”
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Decreased Levels of (6-4) Photoproduct Excision Repair in Hybrid Fish of the Genus Xiphophorus by Mitchell, David L., Nairn, Rodney S., Johnston, Dennis A., Byrom, Michelle, Kazianis, Steven, Walter, Ronald B.

“…ABSTRACT Selected hybridization in the fish genus Xiphophorus has been used for many years to study the genetics of malignant melanoma. Because DNA damage…”
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Spontaneous melanoma formation in nonhybrid Xiphophorus by SCHARTL, A, MALITSCHEK, B, KAZIANIS, S, BOROWSKY, R, SCHARTL, M

“…Melanoma in hybrids of Xiphophorus is due to the unrestricted activity of a cellular oncogene locus, Tu, encoding the growth factor receptor gene Xmrk. In…”
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Use of platyfishes and swordtails in biological research by Kazianis, Steven, Walter, Ronald B

“…The use of platyfishes and swordtails as research models is on the rise. The authors review the basic biology and care of these animals and describe their…”
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Cloning and analysis of a FoxO transcription factor from Xiphophorus by Rudd, Michael D., Johnston, Dennis A., Kazianis, Steven, Butler, Andrew P.

“…Melanoma development in the fish Xiphophorus is determined, at least in part, by overexpression and activation of the Xmrk-2 oncogene, which triggers a variety…”
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Structural organization, mapping, characterization and evolutionary relationships of CDKN2 gene family members in Xiphophorus fishes by Kazianis, Steven, Khanolkar, Vandeeta A., Nairn, Rodney S., Rains, J. Douglas, Trono, David, Garcia, Rachel, Williams, Earlanda L., Walter, Ronald B.

“…Xiphophorus fishes and their hybrids are used as models for the study of melanoma and other diseases. The cyclin-dependent kinase inhibitor gene family in…”
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MNU Induction of Neoplasia in a Platyfish Model by Kazianis, Steven, Gimenez-Conti, Irma, Setlow, Richard B, Woodhead, Avril D, Harshbarger, John C, Trono, David, Ledesma, Mark, Nairn, Rodney S, Walter, Ronald B

“…Interspecific hybrid crosses between members of the fish genus Xiphophorus have been used for over 70 years to study the genetic aspects of melanoma formation…”
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Localization of a CDKN2 gene in linkage group V of Xiphophorus fishes defines it as a candidate for the DIFF tumor suppressor by Kazianis, Steven, Gutbrod, Heidrun, Nairn, Rodney S., McEntire, Brenda B., Coletta, Luis Della, Walter, Ronald B., Borowsky, Richard L., Woodhead, Avril D., Setlow, Richard B., Schartl, Manfred, Morizot, Donald C.

“…The Xiphophorus hybrid melanoma model represents one of the earliest reported cases of genetically regulated tumor susceptibility. Melanoma formation in…”
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Genetic analysis of susceptibility to spontaneous and UV-induced carcinogenesis in Xiphophorus hybrid fish by Nairn, R S, Kazianis, S, Della Coletta, L, Trono, D, Butler, A P, Walter, R B, Morizot, D C

“…Xiphophorus interspecies hybrids provide genetically controlled models of tumor formation. Spontaneous melanomas form in first-generation backcross (BC(1))…”
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Characterization of the CDKN2A and ARF genes in UV-induced melanocytic hyperplasias and melanomas of an opossum (Monodelphis domestica) by Chan, Jeannie, Robinson, Edward S., Atencio, Julia, Wang, Zhiqiang, Kazianis, Steven, Coletta, Luis Della, Nairn, Rodney S., McCarrey, John R.

“…We examined the involvement of the cyclin‐dependent kinase inhibitor 2A (CDKN2A) locus in the pathogenesis of ultraviolet (UV) radiation–induced melanomas in…”
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Alternative splicing of major histocompatibility complex class II DXB transcripts in Xiphophorus fishes by Roney, Kelly E, Cuthbertson, Brandon J, Godwin, Ulla B, Kazianis, Steven, Coletta, Luis Della, Rosenthal, Gil G, Ryan, Michael J, Schmidt, Margit, McConnell, Thomas J

“…Classical MHC class II glycoproteins present peptides to T cells. In Xiphophorus fishes and in the guppy, Poecilia reticulata, a classical MHC class II B-like…”
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Overexpression of a fish CDKN2 gene in a hereditary melanoma model by Kazianis, Steven, Coletta, Luis Della, Morizot, Donald C., Johnston, Dennis A., Osterndorff, Elizabeth A., Nairn, Rodney S.

“…The fish genus Xiphophorus provides a vertebrate model useful in etiological studies of cancer. Hybrid fish can spontaneously develop melanomas deriving from…”
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