Search Results - "Kazi, Julhash U."

FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications by Kazi, Julhash U, Rönnstrand, Lars

“…FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand…”
Get full text

T cell receptor (TCR) signaling in health and disease by Shah, Kinjal, Al-Haidari, Amr, Sun, Jianmin, Kazi, Julhash U.

“…Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside…”
Get full text

Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling by Shah, Kinjal, Kazi, Julhash U

“…WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various cellular processes. While WNT ligands usually signal through their…”
Get full text

Mechanisms of Anticancer Therapy Resistance: The Role of Cancer Stem Cells by Kazi, Julhash U

“…Despite incredible progress in anticancer therapy development, resistance to therapy is the major factor limiting the cure of cancer patients [...]…”
Get full text

Machine learning in the prediction of cancer therapy by Rafique, Raihan, Islam, S.M. Riazul, Kazi, Julhash U.

“…[Display omitted] Resistance to therapy remains a major cause of cancer treatment failures, resulting in many cancer-related deaths. Resistance can occur at…”
Get full text

Venetoclax-Resistant T-ALL Cells Display Distinct Cancer Stem Cell Signatures and Enrichment of Cytokine Signaling by Shah, Kinjal, Al Ashiri, Lina, Nasimian, Ahmad, Ahmed, Mehreen, Kazi, Julhash U

“…Therapy resistance remains one of the major challenges for cancer treatment that largely limits treatment benefits and patient survival. The underlying…”
Get full text

Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling by Kazi, Julhash U, Rönnstrand, Lars

“…Fms-like tyrosine kinase 3 (Flt3) is an important growth factor receptor in hematopoiesis. Gain-of-function mutations of the receptor contribute to the…”
Get full text

A Receptor Tyrosine Kinase Inhibitor Sensitivity Prediction Model Identifies AXL Dependency in Leukemia by Nasimian, Ahmad, Al Ashiri, Lina, Ahmed, Mehreen, Duan, Hongzhi, Zhang, Xiaoyue, Rönnstrand, Lars, Kazi, Julhash U

“…Despite incredible progress in cancer treatment, therapy resistance remains the leading limiting factor for long-term survival. During drug treatment, several…”
Get full text

SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia by Puissant, Alexandre, Fenouille, Nina, Alexe, Gabriela, Pikman, Yana, Bassil, Christopher F., Mehta, Swapnil, Du, Jinyan, Kazi, Julhash U., Luciano, Frédéric, Rönnstrand, Lars, Kung, Andrew L., Aster, Jon C., Galinsky, Ilene, Stone, Richard M., DeAngelo, Daniel J., Hemann, Michael T., Stegmaier, Kimberly

“…Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. Although spleen…”
Get full text

Discovery of a small molecule that inhibits Bcl-3-mediated cyclin D1 expression in melanoma cells by Saamarthy, Karunakar, Ahlqvist, Kristofer, Daams, Renée, Balagunaseelan, Navisraj, Rinaldo-Matthis, Agnes, Kazi, Julhash U, Sime, Wondossen, Massoumi, Ramin

“…Molecular targeted therapy using a drug that suppresses the growth and spread of cancer cells via inhibition of a specific protein is a foundation of precision…”
Get full text

Enhancing cell death in B-cell malignancies through targeted inhibition of Bcl-3 by Daams, Renée, Tran, Thi Thu Phuong, Jemaà, Mohamed, Sime, Wondossen, Mickeviciute, Ruta, Ek, Sara, Rönnstrand, Lars, Kazi, Julhash U., Massoumi, Ramin

“…The t(14;19)(q32;q13) is a rare recurring translocation found in B-cell lymphoproliferative malignancies, involving the Bcl-3 gene. This chromosomal…”
Get full text

Xputer: bridging data gaps with NMF, XGBoost, and a streamlined GUI experience by Younus, Saleena, Rönnstrand, Lars, Kazi, Julhash U

“…The rapid proliferation of data across diverse fields has accentuated the importance of accurate imputation for missing values. This task is crucial for…”
Get full text

A deep tabular data learning model predicting cisplatin sensitivity identifies BCL2L1 dependency in cancer by Nasimian, Ahmad, Ahmed, Mehreen, Hedenfalk, Ingrid, Kazi, Julhash U.

“…Cisplatin, a platinum-based chemotherapeutic agent, is widely used as a front-line treatment for several malignancies. However, treatment outcomes vary widely…”
Get full text

Phosphorylation of the Activation Loop Tyrosine 823 in c-Kit Is Crucial for Cell Survival and Proliferation by Agarwal, Shruti, Kazi, Julhash U., Rönnstrand, Lars

“…The receptor tyrosine kinase c-Kit, also known as the stem cell factor receptor, plays a key role in several developmental processes. Activating mutations in…”
Get full text

Suppressor of Cytokine Signaling 6 (SOCS6) Negatively Regulates Flt3 Signal Transduction through Direct Binding to Phosphorylated Tyrosines 591 and 919 of Flt3 by Kazi, Julhash U., Sun, Jianmin, Phung, Bengt, Zadjali, Fahad, Flores-Morales, Amilcar, Rönnstrand, Lars

“…The receptor tyrosine kinase Flt3 is an important growth factor receptor in hematopoiesis, and gain-of-function mutations of the receptor contribute to the…”
Get full text

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia by Hyrenius-Wittsten, Axel, Pilheden, Mattias, Sturesson, Helena, Hansson, Jenny, Walsh, Michael P., Song, Guangchun, Kazi, Julhash U., Liu, Jian, Ramakrishan, Ramprasad, Garcia-Ruiz, Cristian, Nance, Stephanie, Gupta, Pankaj, Zhang, Jinghui, Rönnstrand, Lars, Hultquist, Anne, Downing, James R., Lindkvist-Petersson, Karin, Paulsson, Kajsa, Järås, Marcus, Gruber, Tanja A., Ma, Jing, Hagström-Andersson, Anna K.

“…Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL ) rearrangements ( KMT2A -R). These mutations are often subclonal and…”
Get full text

Germline mutations of KIT in gastrointestinal stromal tumor (GIST) and mastocytosis by Ke, Hengning, Kazi, Julhash U, Zhao, Hui, Sun, Jianmin

“…Somatic mutations of KIT are frequently found in mastocytosis and gastrointestinal stromal tumor (GIST), while germline mutations of KIT are rare, and only…”
Get full text

The role of HOXB2 and HOXB3 in acute myeloid leukemia by Lindblad, Oscar, Chougule, Rohit A., Moharram, Sausan A., Kabir, Nuzhat N., Sun, Jianmin, Kazi, Julhash U., Rönnstrand, Lars

“…Acute myeloid leukemia (AML) is a heterogeneous aggressive disease and the most common form of adult leukemia. Mutations in the type III receptor tyrosine…”
Get full text

The Aurora kinase/β-catenin axis contributes to dexamethasone resistance in leukemia by Shah, Kinjal, Ahmed, Mehreen, Kazi, Julhash U.

“…Glucocorticoids, such as dexamethasone and prednisolone, are widely used in cancer treatment. Different hematological malignancies respond differently to this…”
Get full text

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia by Kazi, Julhash U., Rönnstrand, Lars

“…The adaptor protein Grb10 plays important roles in mitogenic signaling. However, its roles in acute myeloid leukemia (AML) are predominantly unknown. Here we…”
Get full text