Search Results - "Kazazian, H H"

Mobile DNA in Health and Disease by Kazazian, Haig H, Moran, John V

“…More than half the human genome is derived from transposable elements (also known as mobile DNA or “jumping genes”); some of these elements have been…”
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Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites by Goodier, John L., Kazazian, Haig H.

“…Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome…”
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Mobile Elements: Drivers of Genome Evolution by Kazazian, Haig H.

“…Mobile elements within genomes have driven genome evolution in diverse ways. Particularly in plants and mammals, retrotransposons have accumulated to…”
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Active human retrotransposons: variation and disease by Hancks, Dustin C, Kazazian, Haig H

“…Mobile DNAs, also known as transposons or ‘jumping genes’, are widespread in nature and comprise an estimated 45% of the human genome. Transposons are divided…”
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The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition by Goodier, John L, Pereira, Gavin C, Cheung, Ling E, Rose, Rebecca J, Kazazian, Jr, Haig H

“…Intrinsic immunity describes the set of recently discovered but poorly understood cellular mechanisms that specifically target viral pathogens. Their discovery…”
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L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells by Kazazian, Haig H, Yang, Nuo

“…LINE-1s, or L1s, are highly abundant retrotransposons comprising 17% of the human genome. Most L1s are retrotransposition defective; nonetheless, there are…”
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High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes by Ewing, Adam D, Kazazian, Jr, Haig H

“…Using high-throughput sequencing, we devised a technique to determine the insertion sites of virtually all members of the human-specific L1 retrotransposon…”
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Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1 by Zhao, Ke, Du, Juan, Han, Xue, Goodier, John L., Li, Peng, Zhou, Xiaohong, Wei, Wei, Evans, Sean L., Li, Linzhang, Zhang, Wenyan, Cheung, Ling E., Wang, Guanjun, Kazazian, Haig H., Yu, Xiao-Fang

“…Long interspersed elements 1 (LINE-1) occupy at least 17% of the human genome and are its only active autonomous retrotransposons. However, the host factors…”
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A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells by Nguyen, Giang N., Everett, John K., Kafle, Samita, Roche, Aoife M., Raymond, Hayley E., Leiby, Jacob, Wood, Christian, Assenmacher, Charles-Antoine, Merricks, Elizabeth P., Long, C. Tyler, Kazazian, Haig H., Nichols, Timothy C., Bushman, Frederic D., Sabatino, Denise E.

“…Nine dogs with hemophilia A were treated with adeno-associated viral (AAV) gene therapy and followed for up to 10 years. Administration of AAV8 or AAV9 vectors…”
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LINE-1 expression and retrotransposition in Barrett’s esophagus and esophageal carcinoma by Doucet-O’Hare, Tara T., Rodic, Nemanja, Sharma, Reema, Darbari, Isha, Abril, Gabriela, Choi, Jungbin A., Ahn, Ji Young, Cheng, Yulan, Anders, Robert A., Burns, Kathleen H., Meltzer, Stephen J., Kazazian, Haig H.

“…Barrett’s esophagus (BE) is a common disease in which the lining of the esophagus transitions from stratified squamous epithelium to metaplastic columnar…”
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Roles for retrotransposon insertions in human disease by Hancks, Dustin C, Kazazian, Jr, Haig H

“…Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of transposable elements (TE) such as retrotransposons. On a shorter…”
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MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells by Goodier, John L, Cheung, Ling E, Kazazian, Jr, Haig H

“…MOV10 protein, a putative RNA helicase and component of the RNA-induced silencing complex (RISC), inhibits retrovirus replication. We show that MOV10 also…”
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Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition by Goodier, John L, Cheung, Ling E, Kazazian, Jr, Haig H

“…LINE1s occupy 17% of the human genome and are its only active autonomous mobile DNA. L1s are also responsible for genomic insertion of processed pseudogenes…”
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Hot L1s Account for the Bulk of Retrotransposition in the Human Population by Brouha, Brook, Schustak, Joshua, Badge, Richard M., Lutz-Prigge, Sheila, Farley, Alexander H., Moran, John V., Kazazian, Haig H.

“…Although LINE-1 (long interspersed nucleotide element-1, L1) retrotransposons comprise 17% of the human genome, an exhaustive search of the December 2001…”
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Current topics in genome evolution: Molecular mechanisms of new gene formation by Babushok, D. V, Ostertag, E. M, Kazazian, H. H. Jr

“…Comparative genome analyses reveal that most functional domains of human genes have homologs in widely divergent species. These shared functional domains,…”
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Exon Shuffling by L1 Retrotransposition by Moran, John V., DeBerardinis, Ralph J., Kazazian, Haig H.

“…Long interspersed nuclear elements (LINE-1s or L1s) are the most abundant retrotransposons in the human genome, and they serve as major sources of reverse…”
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BIOLOGY OF MAMMALIAN L1 RETROTRANSPOSONS by Ostertag, Eric M, Kazazian Jr, Haig H

“…L1 retrotransposons comprise 17% of the human genome. Although most L1s are inactive, some elements remain capable of retrotransposition. L1 elements have a…”
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Whole-genome resequencing allows detection of many rare LINE-1 insertion alleles in humans by Ewing, Adam D, Kazazian, Jr, Haig H

“…High-throughput sequencing has recently begun to revolutionize the study of structural variants in the genomes of humans and other species. More recently, this…”
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L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism by Kano, Hiroki, Godoy, Irene, Courtney, Christine, Vetter, Melissa R, Gerton, George L, Ostertag, Eric M, Kazazian, Jr, Haig H

“…Long Interspersed Element 1 (L1) is a retrotransposon that comprises approximately 17% of the human genome. Despite its abundance in mammalian genomes,…”
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Extensive somatic L1 retrotransposition in colorectal tumors by Solyom, Szilvia, Ewing, Adam D, Rahrmann, Eric P, Doucet, Tara, Nelson, Heather H, Burns, Michael B, Harris, Reuben S, Sigmon, David F, Casella, Alex, Erlanger, Bracha, Wheelan, Sarah, Upton, Kyle R, Shukla, Ruchi, Faulkner, Geoffrey J, Largaespada, David A, Kazazian, Jr, Haig H

“…L1 retrotransposons comprise 17% of the human genome and are its only autonomous mobile elements. Although L1-induced insertional mutagenesis causes Mendelian…”
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