Search Results - "Kazantsev, Aleksey G."

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders by Kazantsev, Aleksey G, Thompson, Leslie M

“…Key Points This Review focuses on the family of histone deacetylases (HDACs) and their regulatory roles in cells with specific application to neurons. It…”
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Sirtuins in Alzheimer's Disease: SIRT2-Related GenoPhenotypes and Implications for PharmacoEpiGenetics by Cacabelos, Ramón, Carril, Juan C, Cacabelos, Natalia, Kazantsev, Aleksey G, Vostrov, Alex V, Corzo, Lola, Cacabelos, Pablo, Goldgaber, Dmitry

“…Sirtuins (SIRT1-7) are NAD⁺-dependent protein deacetylases/ADP ribosyltransferases with important roles in chromatin silencing, cell cycle regulation, cellular…”
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The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models by Chopra, Vanita, Quinti, Luisa, Kim, Jinho, Vollor, Lorraine, Narayanan, K. Lakshmi, Edgerly, Christina, Cipicchio, Patricia M., Lauver, Molly A., Choi, Soo Hyuk, Silverman, Richard B., Ferrante, Robert J., Hersch, Steven, Kazantsev, Aleksey G.

“…Inhibition of sirtuin 2 (SIRT2) deacetylase mediates protective effects in cell and invertebrate models of Parkinson’s disease and Huntington’s disease (HD)…”
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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients by Quinti, Luisa, Naidu, Sharadha Dayalan, Träger, Ulrike, Chen, Xiqun, Kegel-Gleason, Kimberly, Llères, David, Connolly, Colúm, Chopra, Vanita, Low, Cho, Moniot, Sébastien, Sapp, Ellen, Tousley, Adelaide R., Vodicka, Petr, Van Kanegan, Michael J., Kaltenbach, Linda S., Crawford, Lisa A., Fuszard, Matthew, Higgins, Maureen, Miller, James R. C., Farmer, Ruth E., Potluri, Vijay, Samajdar, Susanta, Meisel, Lisa, Zhang, Ningzhe, Snyder, Andrew, Stein, Ross, Hersch, Steven M., Ellerby, Lisa M., Weerapana, Eranthie, Schwarzschild, Michael A., Steegborn, Clemens, Leavitt, Blair R., Degterev, Alexei, Tabrizi, Sarah J., Lo, Donald C., DiFiglia, Marian, Thompson, Leslie M., Dinkova-Kostova, Albena T., Kazantsev, Aleksey G.

“…The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of…”
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The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia by Chen, Xiqun, Wales, Pauline, Quinti, Luisa, Zuo, Fuxing, Moniot, Sébastien, Herisson, Fanny, Rauf, Nazifa Abdul, Wang, Hua, Silverman, Richard B, Ayata, Cenk, Maxwell, Michelle M, Steegborn, Clemens, Schwarzschild, Michael A, Outeiro, Tiago F, Kazantsev, Aleksey G

“…Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2)…”
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SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis by Luthi-Carter, Ruth, Taylor, David M, Pallos, Judit, Lambert, Emmanuel, Amore, Allison, Parker, Alex, Moffitt, Hilary, Smith, Donna L, Runne, Heike, Gokce, Ozgun, Kuhn, Alexandre, Xiang, Zhongmin, Maxwell, Michele M, Reeves, Steven A, Bates, Gillian P, Neri, Christian, Thompson, Leslie M, Marsh, J. Lawrence, Kazantsev, Aleksey G

“…Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal…”
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SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models by Quinti, Luisa, Casale, Malcolm, Moniot, Sébastien, Pais, Teresa F, Van Kanegan, Michael J, Kaltenbach, Linda S, Pallos, Judit, Lim, Ryan G, Naidu, Sharadha Dayalan, Runne, Heike, Meisel, Lisa, Rauf, Nazifa Abdul, Leyfer, Dmitriy, Maxwell, Michele M, Saiah, Eddine, Landers, John E, Luthi-Carter, Ruth, Abagyan, Ruben, Dinkova-Kostova, Albena T, Steegborn, Clemens, Marsh, J Lawrence, Lo, Donald C, Thompson, Leslie M, Kazantsev, Aleksey G

“…There are currently no disease-modifying therapies for the neurodegenerative disorder Huntington's disease (HD). This study identified novel…”
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SIRT2 as a Therapeutic Target for Age-Related Disorders by de Oliveira, Rita Machado, Sarkander, Jana, Kazantsev, Aleksey G, Outeiro, Tiago Fleming

“…Sirtuin proteins are conserved regulators of aging that have recently emerged as important modifiers of several diseases which commonly occur later in life…”
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A Potent Small Molecule Inhibits Polyglutamine Aggregation in Huntington's Disease Neurons and Suppresses Neurodegeneration in vivo by Zhang, Xiaoqian, Smith, Donna L., Meriin, Anatoli B., Engemann, Sabine, Russel, Deborah E., Roark, Margo, Washington, Shetia L., Maxwell, Michele M., Marsh, J. Lawrence, Thompson, Leslie Michels, Wanker, Erich E., Young, Anne B., Housman, David E., Bates, Gillian P., Sherman, Michael Y., Kazantsev, Aleksey G.

“…Polyglutamine (polyQ) disorders, including Huntington's disease (HD), are caused by expansion of polyQ-encoding repeats within otherwise unrelated gene…”
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Pharmacological Promotion of Inclusion Formation: A Therapeutic Approach for Huntington's and Parkinson's Diseases by Bodner, Ruth A., Outeiro, Tiago Fleming, Altmann, Stephen, Maxwell, Michele M., Cho, Stephanie H., Hyman, Bradley T., McLean, Pamela J., Young, Anne B., Housman, David E., Kazantsev, Aleksey G.

“…Misfolded proteins accumulate in many neurodegenerative diseases, including huntingtin in Huntington's disease and α-synuclein in Parkinson's disease. The…”
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The role of Nrf2 signaling in counteracting neurodegenerative diseases by Dinkova‐Kostova, Albena T., Kostov, Rumen V., Kazantsev, Aleksey G.

“…The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the interface of cellular redox and intermediary metabolism. Nrf2…”
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Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia by Spires-Jones, Tara L, Fox, Leora M, Rozkalne, Anete, Pitstick, Rose, Carlson, George A, Kazantsev, Aleksey G

“…Tauopathies including tau-associated Frontotemporal dementia (FTD) and Alzheimer's disease are characterized pathologically by the formation of tau-containing…”
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Identification of Tri- and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors by Rotili, Dante, Tarantino, Domenico, Carafa, Vincenzo, Lara, Ester, Meade, Sarah, Botta, Giorgia, Nebbioso, Angela, Schemies, Jörg, Jung, Manfred, Kazantsev, Aleksey G., Esteller, Manel, Fraga, Mario F., Altucci, Lucia, Mai, Antonello

“…Sirtuins are deacetylase proteins that regulate transcription, genome maintenance, longevity, and metabolism. Eight compounds were identified as a novel class…”
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Loss of Huntingtin Function Complemented by Small Molecules Acting as Repressor Element 1/Neuron Restrictive Silencer Element Silencer Modulators by Rigamonti, Dorotea, Bolognini, Daniele, Mutti, Cesare, Zuccato, Chiara, Tartari, Marzia, Sola, Francesco, Valenza, Marta, Kazantsev, Aleksey G., Cattaneo, Elena

“…Increased levels of the repressor element 1/neuron restrictive silencer element (RE1/NRSE) silencing activity promoter, and a consequent reduction in the…”
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Editorial on special topic: sirtuins in metabolism, aging, and disease by Kazantsev, Aleksey G, Outeiro, Tiago F

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New Directions for Neurodegenerative Disease Therapy: Using Chemical Compounds to Boost the Formation of Mutant Protein Inclusions by Bodner, Ruth A., Housman, David E., Kazantsev, Aleksey G.

“…Neurodegenerative disease such as Huntington's, Parkinson's, and Alzheimer'sdiseases are marked by neuronal accumulation of toxic misfolded protein…”
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Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease by Outeiro, Tiago Fleming, Kontopoulos, Eirene, Altmann, Stephen M, Kufareva, Irina, Strathearn, Katherine E, Amore, Allison M, Volk, Catherine B, Maxwell, Michele M, Rochet, Jean-Christophe, McLean, Pamela J, Young, Anne B, Abagyan, Ruben, Feany, Mel B, Hyman, Bradley T, Kazantsev, Aleksey G

“…The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We…”
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RNA Interference-Mediated Silencing of Mutant Superoxide Dismutase Rescues Cyclosporin A-Induced Death in Cultured Neuroblastoma Cells by Maxwell, Michele M., Pasinelli, Piera, Kazantsev, Aleksey G., Brown, Robert H., Housman, David E.

“…Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disorder resulting from selective death of motor neurons in the brain and…”
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The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS by Maxwell, Michele M., Tomkinson, Elizabeth M., Nobles, Johnathan, Wizeman, John W., Amore, Allison M., Quinti, Luisa, Chopra, Vanita, Hersch, Steven M., Kazantsev, Aleksey G.

“…Sirtuin 2 (SIRT2) is one of seven known mammalian protein deacetylases homologous to the yeast master lifespan regulator Sir2. In recent years, the sirtuin…”
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Huntington's disease: From molecular basis to therapeutic advances by Krobitsch, Sylvia, Kazantsev, Aleksey G.

“…Huntington's disease is an autosomal dominant genetic neurodegenerative disorder, which is characterized by progressive motor dysfunction, emotional…”
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