Search for and study of biologically active substances with psychotropic activity among the N-nicotinoyl derivatives of glutamic and gamma-aminobutyric acids

Four new derivatives of glutamic and gamma-aminobutyric acids influencing the central nervous system were produced. By the character of their action they refer to the substances of the sedating tranquilizing type without the myorelaxant component. The drug activity degree depends on its ability to p...

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Bibliographic Details
Published in:	Farmakologiia i toksikologiia Vol. 51; no. 1; p. 12
Main Authors:	Kuz'menko, G I, Gotsuliak, L E, Gaĭdenko, A I, Kazanov, A D, Niiaka, M F
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1988
Subjects:	Animals Cell Membrane Permeability - drug effects Dose-Response Relationship, Drug gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - pharmacology Glutamates - pharmacology Glutamic Acid Mice Motor Activity - drug effects Nicotinic Acids - pharmacology Psychotropic Drugs - pharmacology Structure-Activity Relationship
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Summary:	Four new derivatives of glutamic and gamma-aminobutyric acids influencing the central nervous system were produced. By the character of their action they refer to the substances of the sedating tranquilizing type without the myorelaxant component. The drug activity degree depends on its ability to penetrate through cell membranes that is in turn determined by the structure of the compound.
ISSN:	0014-8318