Search Results - "Kayne, Paul S"

Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer by Manjarrez-Orduño, Nataly, Menard, Laurence C, Kansal, Selena, Fischer, Paul, Kakrecha, Bijal, Jiang, Can, Cunningham, Mark, Greenawalt, Danielle, Patel, Vishal, Yang, Minghui, Golhar, Ryan, Carman, Julie A, Lezhnin, Sergey, Dai, Hongyue, Kayne, Paul S, Suchard, Suzanne J, Bernstein, Steven H, Nadler, Steven G

“…Agents targeting the PD1-PDL1 axis have transformed cancer therapy. Factors that influence clinical response to PD1-PDL1 inhibitors include tumor mutational…”
Get full text

A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans by Dodd, John, Jordan, Robert, Makhlina, Marie, Barnett, Keith, Roffel, Ad, Spana, Carl, Obr, Alison, Dhingra, Priyanka, Kayne, Paul S

“…PL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated…”
Get full text

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits by Civelek, Mete, Hagopian, Raffi, Pan, Calvin, Che, Nam, Yang, Wen-pin, Kayne, Paul S, Saleem, Niyas K, Cederberg, Henna, Kuusisto, Johanna, Gargalovic, Peter S, Kirchgessner, Todd G, Laakso, Markku, Lusis, Aldons J

“…The genetics of messenger RNA (mRNA) expression has been extensively studied in humans and other organisms, but little is known about genetic factors…”
Get full text

Transcriptomic responses to sodium chloride-induced osmotic stress: A study of industrial fed-batch CHO cell cultures by Shen, Duan, Kiehl, Thomas R., Khattak, Sarwat F., Li, Zheng Jian, He, Aiqing, Kayne, Paul S., Patel, Vishal, Neuhaus, Isaac M., Sharfstein, Susan T.

“…The rapidly expanding market for monoclonal antibody and Fc‐fusion‐protein therapeutics has increased interest in improving the productivity of mammalian cell…”
Get full text

S1014 Cellular and Molecular Impact of the Melanocortin Receptor Agonist PL8177 in Dextran Sulfate Sodium-Induced Colitis in Rats by Dhingra, Priyanka, Obr, Alison, Spana, Carl, Dodd, John H., Kayne, Paul S.

Get full text

Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities by Ji, Rui-Ru, de Silva, Heshani, Jin, Yisheng, Bruccoleri, Robert E, Cao, Jian, He, Aiqing, Huang, Wenjun, Kayne, Paul S, Neuhaus, Isaac M, Ott, Karl-Heinz, Penhallow, Becky, Cockett, Mark I, Neubauer, Michael G, Siemers, Nathan O, Ross-Macdonald, Petra

“…The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to…”
Get full text

Exome sequencing reveals comprehensive genomic alterations across eight cancer cell lines by Chang, Han, Jackson, Donald G, Kayne, Paul S, Ross-Macdonald, Petra B, Ryseck, Rolf-Peter, Siemers, Nathan O

“…It is well established that genomic alterations play an essential role in oncogenesis, disease progression, and response of tumors to therapeutic intervention…”
Get full text

Hypoxia and transforming growth factor‐beta1 pathway activation promote Chinese Hamster Ovary cell aggregation by Qian, Yueming, Rehmann, Matthew S., Qian, Nan‐Xin, He, Aiqing, Borys, Michael C., Kayne, Paul S., Li, Zheng Jian

“…Suspension cultivation is the preferred mode of operation for the large‐scale production of many biologics. Chinese Hamster Ovary (CHO) cells are…”
Get full text

Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells by Qian, Yueming, Khattak, Sarwat F., Xing, Zizhuo, He, Aiqing, Kayne, Paul S., Qian, Nan-Xin, Pan, Shih-Hsie, Li, Zheng Jian

“…This study reports the effects of varying concentrations of copper sulfate on the metabolic and gene transcriptional profile of a recombinant Chinese hamster…”
Get full text

Hypoxia influences protein transport and epigenetic repression of CHO cell cultures in shake flasks by Qian, Yueming, Xing, Zizhuo, Lee, Sherry, Mackin, Nancy A., He, Aiqing, Kayne, Paul S., He, Qin, Qian, Nan-Xin, Li, Zheng Jian

“…Shake flasks and bench‐top bioreactors are widely used for cell culture process development, however, culture performances significantly differ between them…”
Get full text

Yeast histone H4 N-terminal sequence is required for promoter activation in vivo by Durrin, L K, Mann, R K, Kayne, P S, Grunstein, M

“…To search for histone domains that may regulate transcription in vivo, we made deletions and amino acid substitutions in the histone N-termini of S…”
Get more information

Sequence of glutamine synthetase from Salmonella typhimurium and implications for the protein structure by Janson, C A, Kayne, P S, Almassy, R J, Grunstein, M, Eisenberg, D

“…To aid in the interpretation of the 3.5 A resolution electron density map of glutamine synthetase (GS) from Salmonella typhimurium, the nucleotide sequence of…”
Get more information

Semi-Automated Sample Preparation for Plasma Proteomics by Ho, Keith, Xiao, Qing, Fach, Estelle M., Hulmes, Jeffrey D., Bethea, Deidra, Opiteck, Gregory J., Lu, Joseph Y., Kayne, Paul S., Hefta, Stanley A.

“…The discovery of new biomarkers will be an essential step to enhance our ability to better diagnose and treat human disease. The proteomics research community…”
Get full text

Transcriptional Profiling of the Dose Response: A More Powerful Approach for Characterizing Drug Activities: e1000512 by Ji, Rui-Ru, Silva, Heshani de, Jin, Yisheng, Bruccoleri, Robert E, Cao, Jian, He, Aiqing, Huang, Wenjun, Kayne, Paul S, Neuhaus, Isaac M, Ott, Karl-Heinz, Penhallow, Becky, Cockett, Mark I, Neubauer, Michael G, Siemers, Nathan O, Ross-Macdonald, Petra

“…The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to…”
Get full text

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci Saccharomyces cerevisiae by Johnson, L.M. (University of California, Los Angeles, CA), Kayne, P.S, Kahn, E.S, Grunstein, M

“…Repression of transcription from the silent mating loci (HMLα and HMRa) is essential for mating ability in Saccharomyces cerevisiae. This silencing is known to…”
Get full text

Ras pathways in Caenorhabditis elegans by Kayne, P S, Sternberg, P W

“…The let-60 ras gene of Caenorhabditis elegans is required for multiple aspects of development. The vulvar differentiation pathway is the most intensively…”
Get more information

Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast by Kayne, P S, Kim, U J, Han, M, Mullen, J R, Yoshizaki, F, Grunstein, M

“…Yeast histone H4 function was probed in vivo by deleting segments of this extremely conserved 102 amino acid protein. Deletions in the hydrophobic core of H4…”
Get more information

Autonomous replication sequences in the maxicircle kinetoplast DNA of Leishmania tarentolae by Hughes, D, Simpson, L, Kayne, P S, Neckelmann, N

“…Four fragments from the maxicircle DNA of Leishmania tarentolae cloned into the selectable Saccharomyces cerevisiae shuttle vector, YIp5, exhibited autonomous…”
Get more information