The quality of life in hemodialysis patients with chronic hepatitis C virus infection

We aimed to determine the quality of life in treated and untreated hemodialysis patients with chronic hepatitis C virus infection. Ninety-five chronic renal failure patients with positive antiHCV/HCV-RNA were enrolled in this prospective study. All patients were questioned using the Short Form-36 (S...

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Bibliographic Details
Published in:	The Turkish journal of gastroenterology Vol. 20; no. 4; pp. 243 - 246
Main Authors:	Akyüz, Filiz, Beşişik, Fatih, Pinarbaşi, Binnur, Demir, Kadir, Kaymakoğlu, Sabahattin Tolga, Cakaloğlu, Yilmaz, Sever, Mehmet Sükrü, Okten, Atilla
Format:	Journal Article
Language:	English
Published:	Turkey Türk Gastroenteroloji Vakfı 01-12-2009
Subjects:	Adult Antiviral Agents - therapeutic use Anxiety - psychology Female Health Surveys Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - psychology Humans Interferon alpha-2 Interferon-alpha - therapeutic use Kidney Failure, Chronic - psychology Kidney Failure, Chronic - surgery Kidney Failure, Chronic - therapy Kidney Transplantation - psychology Male Middle Aged Motor Activity Quality of Life Recombinant Proteins Renal Dialysis - psychology Surveys and Questionnaires
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Summary:	We aimed to determine the quality of life in treated and untreated hemodialysis patients with chronic hepatitis C virus infection. Ninety-five chronic renal failure patients with positive antiHCV/HCV-RNA were enrolled in this prospective study. All patients were questioned using the Short Form-36 (SF-36) health survey to evaluate life quality after the treatment. Fifty-five (ALT>1.5 ULN) were treated with interferon-alpha-2b [3MU/tiw, sc, 6 (30 patients) and 12 (25 patients) months], and 40 (11 renal transplanted) were untreated. Fifteen patients had renal transplantation in a mean of 24.6+/-12.5 months after interferon-alpha treatment. The mean age of the patients was 37+/-10 years, and 58 were male. The mean durations of hemodialysis and renal transplantation were 6.4+/-3.8 and 5.9+/-4.6 years, respectively. Interferon treatment had a negative effect on general health perception, physical activity and anxiety about the disease (p<0.05) when compared with the untreated patients. General health perception scores were positively slightly increased in interferon responder patients (p>0.05). General health and physical activity were better in transplanted patients than patients undergoing hemodialysis (p<0.05). General health perception slightly increased positively in interferon responder patients. However, general health perception and physical activity were affected negatively by interferon treatment in the whole group analysis. Renal-transplanted patients have a better life quality compared with those on hemodialysis.
Bibliography:	TTIP
ISSN:	1300-4948 2148-5607
DOI:	10.4318/tjg.2009.0020