Search Results - "Kayed, R."

Tau oligomers as potential targets for immunotherapy for Alzheimer's disease and tauopathies by Lasagna-Reeves, C A, Castillo-Carranza, D L, Jackson, G R, Kayed, R

“…The aggregation and accumulation of the microtubule-associated protein (Tau) is a pathological hallmark of Alzheimer disease (AD) and many neurodegenerative…”
Get more information

Tau oligomer antibodies as potential therapeutics for parkinson’s and other synucleinopathies by Gerson, J, Castillo-Carranza, D.L, Sengupta, U, Henson, N, Nilson, A, Kayed, R

Get full text

Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis by Clos, A.L., Lasagna-Reeves, C.A., Castillo-Carranza, D.L., Sengupta, U., Jackson, G.R., Kelly, B., Beachkofsky, T.M., Kayed, R.

“…Summary Background  Primary cutaneous nodular amyloidosis (PCNA) is thought to be a plasma cell dyscrasia. The amyloid deposits are found in the dermis and…”
Get full text

TRIM28 regulates the stability and toxicity of alpha-synuclein and tau through a common mechanism by Rousseaux, M.W.C, de Haro, M, Lasagna-Reeves, C.A, De Maio, A, Jafar-Nejad, P, Park, J, Al-Ramahi, I, Kayed, R, Botas, H, Zoghbi, H.Y

Get full text

Effects of Gum Arabic in rats with adenine-induced chronic renal failure by Ali, Badreldin H, Al-Salam, Suhail, Al Husseni, Isehaq, Kayed, Rana R, Al-Masroori, Noura, Al-Harthi, Thuriya, Al Zaabi, Mohamed, Nemmar, Abderrahim

“…Gum Arabic (GA [Acacia senegal]) is reputed, in Arabian medicinal practices, to be useful in treating patients with chronic renal failure (CRF), albeit without…”
Get more information

A specific amyloid-β protein assembly in the brain impairs memory by Glabe, Charles G, Kotilinek, Linda, Gallagher, Michela, Koh, Ming Teng, Ashe, Karen H, Kayed, Rakez, Lesné, Sylvain, Yang, Austin

“…Memory function often declines with age, and is believed to deteriorate initially because of changes in synaptic function rather than loss of neurons. Some…”
Get full text

Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis by Glabe, Charles G, Kayed, Rakez

“…Recent findings indicate that soluble amyloid oligomers may represent the primary pathologic species in degenerative diseases. These amyloid oligomers share…”
Get full text

Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers by Demuro, Angelo, Mina, Erene, Kayed, Rakez, Milton, Saskia C., Parker, Ian, Glabe, Charles G.

“…Increasing evidence suggests that amyloid peptides associated with a variety of degenerative diseases induce neurotoxicity in their intermediate oligomeric…”
Get full text

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo by Yang, Fusheng, Lim, Giselle P., Begum, Aynun N., Ubeda, Oliver J., Simmons, Mychica R., Ambegaokar, Surendra S., Chen, Pingping P., Kayed, Rakez, Glabe, Charles G., Frautschy, Sally A., Cole, Gregory M.

“…Alzheimer's disease (AD) involves amyloid β (Aβ) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and…”
Get full text

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction by Oddo, Salvatore, Caccamo, Antonella, Shepherd, Jason D, Murphy, M.Paul, Golde, Todd E, Kayed, Rakez, Metherate, Raju, Mattson, Mark P, Akbari, Yama, LaFerla, Frank M

“…The neuropathological correlates of Alzheimer's disease (AD) include amyloid-β (Aβ) plaques and neurofibrillary tangles. To study the interaction between Aβ…”
Get full text

Permeabilization of Lipid Bilayers Is a Common Conformation-dependent Activity of Soluble Amyloid Oligomers in Protein Misfolding Diseases by Kayed, Rakez, Sokolov, Yuri, Edmonds, Brian, McIntire, Theresa M, Milton, Saskia C, Hall, James E, Glabe, Charles G

“…Amyloid fibrillization is multistep process involving soluble oligomeric intermediates, including spherical oligomers and protofibrils. Amyloid oligomers have…”
Get full text

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis by Kayed, Rakez, Head, Elizabeth, Thompson, Jennifer L., McIntire, Theresa M., Milton, Saskia C., Cotman, Carl W., Glabe, Charles G.

“…Soluble oligomers are common to most amyloids and may represent the primary toxic species of amyloids, like the Aβ peptide in Alzheimer's disease (AD). Here we…”
Get full text

Methylene Blue Inhibits Amyloid Aβ Oligomerization by Promoting Fibrillization by Necula, Mihaela, Breydo, Leonid, Milton, Saskia, Kayed, Rakez, van der Veer, Wytze E, Tone, Paul, Glabe, Charles G

“…Amyloid plaques are hallmark neuropathological lesions in Alzheimer's disease, which consist of abnormally aggregated Aβ protein. Multiple Aβ aggregated…”
Get full text

Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers by Luibl, Volker, Isas, Jose M, Kayed, Rakez, Glabe, Charles G, Langen, Ralf, Chen, Jeannie

“…Protein misfolding and aggregation are thought to underlie the pathogenesis of many amyloid diseases, such as Alzheimer and Parkinson diseases, whereby a…”
Get full text

Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders by Kayed, Rakez, Jackson, George R

“…Alzheimer disease (AD) is the most common neurodegenerative disorder. Currently available therapies may slow cognitive decline but do not alter underlying…”
Get full text

Structural and Dynamic Features of Alzheimer's Aβ Peptide in Amyloid Fibrils Studied by Site-directed Spin Labeling by Török, Marianna, Milton, Saskia, Kayed, Rakez, Wu, Peng, McIntire, Theresa, Glabe, Charles G., Langen, Ralf

Get full text

Desmin-Related Cardiomyopathy in Transgenic Mice: A Cardiac Amyloidosis by Sanbe, Atsushi, Osinska, Hanna, Saffitz, Jeffrey E., Glabe, Charles G., Kayed, Rakez, Maloyan, Alina, Robbins, Jeffrey, Olson, Eric N.

“…An R120G missense mutation in the small heat shock protein α-B-crystallin ( CryAB R120 G) causes desmin-related cardiomyopathy (DRM). DRM is characterized by…”
Get full text

Soluble Aβ oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain by Kokubo, Hideko, Kayed, Rakez, Glabe, Charles G., Yamaguchi, Haruyasu

“…Soluble Aβ oligomers have recently been considered to be responsible for cognitive dysfunction prior to senile plaque (SP) formation in Alzheimer's disease…”
Get full text

Poloxamer 188 Copolymer Membrane Sealant Rescues Toxicity of Amyloid Oligomers In Vitro by Mina, Erene W., Lasagna-Reeves, Cristian, Glabe, Charles G., Kayed, Rakez

“…Amyloid oligomers and protofibrils increase cell membrane permeability, eventually leading to cell death. Here, we demonstrate that amyloid oligomer toxicity…”
Get full text

Reversal of Amyloid-Induced Heart Disease in Desmin-Related Cardiomyopathy by Sanbe, Atsushi, Osinska, Hanna, Villa, Chet, Gulick, James, Klevitsky, Raisa, Glabe, Charles G., Kayed, Rakez, Robbins, Jeffrey, Olson, Eric N.

“…Amyloid oligomers, similar to the toxic entities found in Alzheimer's disease patients and in other amyloid-based diseases, are present in cardiomyocytes…”
Get full text