Search Results - "Kaye, Julia A"

The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein by Fontaine, Krystal A, Leon, Kristoffer E, Khalid, Mir M, Tomar, Sakshi, Jimenez-Morales, David, Dunlap, Mariah, Kaye, Julia A, Shah, Priya S, Finkbeiner, Steve, Krogan, Nevan J, Ott, Melanie

“…Zika virus (ZIKV) infection of neural progenitor cells (NPCs) is associated with neurological disorders, such as microcephaly, but a detailed molecular…”
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Sequence-Level Analysis of the Major European Huntington Disease Haplotype by Lee, Jong-Min, Kim, Kyung-Hee, Shin, Aram, Chao, Michael J., Abu Elneel, Kawther, Gillis, Tammy, Mysore, Jayalakshmi Srinidhi, Kaye, Julia A., Zahed, Hengameh, Kratter, Ian H., Daub, Aaron C., Finkbeiner, Steven, Li, Hong, Roach, Jared C., Goodman, Nathan, Hood, Leroy, Myers, Richard H., MacDonald, Marcy E., Gusella, James F.

“…Huntington disease (HD) reflects the dominant consequences of a CAG-repeat expansion in HTT. Analysis of common SNP-based haplotypes has revealed that most…”
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Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans by O’Halloran, Damien M., Altshuler-Keylin, Svetlana, Zhang, Xiao-Dong, He, Chao, Morales-Phan, Christopher, Yu, Yawei, Kaye, Julia A., Brueggemann, Chantal, Chen, Tsung-Yu, L’Etoile, Noelle D.

“…In Caenorhabditis elegans , the AWC neurons are thought to deploy a cGMP signaling cascade in the detection of and response to AWC sensed odors. Prolonged…”
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High-throughput screening in primary neurons by Sharma, Punita, Ando, D Michael, Daub, Aaron, Kaye, Julia A, Finkbeiner, Steven

“…Despite years of incremental progress in our understanding of diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD),…”
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Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation by Lee, Jin I., O'Halloran, Damien M., Eastham-Anderson, Jeffery, Juang, Bi-Tzen, Kaye, Julia A., Hamilton, O. Scott, Lesch, Bluma, Goga, Andrei, L'Etoile, Noelle D., Bargmann, Cornelia

“…To navigate a complex and changing environment, an animal's sensory neurons must continually adapt to persistent cues while remaining responsive to novel…”
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DNA Breaks Promote Genomic Instability by Impeding Proper Chromosome Segregation by Kaye, Julia A., Melo, Justine A., Cheung, Stephanie K., Vaze, Moreshwar B., Haber, James E., Toczyski, David P.

“…Background: Unrepaired DNA double-stranded breaks (DSBs) can result in the whole or partial loss of chromosomes. Previously, we showed that the ends of broken…”
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Modeling Huntington's disease with induced pluripotent stem cells by Kaye, Julia A., Finkbeiner, Steven

“…Huntington's disease (HD) causes severe motor dysfunction, behavioral abnormalities, cognitive impairment and death. Investigations into its molecular…”
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Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects by Workman, Michael J., Lim, Ryan G., Wu, Jie, Frank, Aaron, Ornelas, Loren, Panther, Lindsay, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Valencia, Viviana, Gomez, Emilda, Liu, Chunyan, Moran, Ruby, Pinedo, Louis, Tsitkov, Stanislav, Ho, Ritchie, Kaye, Julia A., Thompson, Terri, Rothstein, Jeffrey D., Finkbeiner, Steven, Fraenkel, Ernest, Sareen, Dhruv, Thompson, Leslie M., Svendsen, Clive N.

“…Using induced pluripotent stem cells (iPSCs) to understand the mechanisms of neurological disease holds great promise; however, there is a lack of well-curated…”
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Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites by Kedaigle, Amanda J, Fraenkel, Ernest, Atwal, Ranjit S, Wu, Min, Gusella, James F, MacDonald, Marcy E, Kaye, Julia A, Finkbeiner, Steven, Mattis, Virginia B, Tom, Colton M, Svendsen, Clive, King, Alvin R, Chen, Yumay, Stocksdale, Jennifer T, Lim, Ryan G, Casale, Malcolm, Wang, Ping H, Thompson, Leslie M, Akimov, Sergey S, Ratovitski, Tamara, Arbez, Nicolas, Ross, Christopher A

“…Altered cellular metabolism is believed to be an important contributor to pathogenesis of the neurodegenerative disorder Huntington's disease (HD). Research…”
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A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons by Kaye, Julia A, Rose, Natalie C, Goldsworthy, Brett, Goga, Andrei, L'Etoile, Noelle D

“…Prolonged stimulation leads to specific and stable changes in an animal's behavior. In interneurons, this plasticity requires spatial and temporal control of…”
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Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines by Baxi, Emily G., Thompson, Terri, Kaye, Julia A., Lim, Ryan G., Wu, Jie, Ramamoorthy, Divya, Lima, Leandro, Vaibhav, Vineet, Matlock, Andrea, Frank, Aaron, Coyne, Alyssa N., Landin, Barry, Ornelas, Loren, Mosmiller, Elizabeth, Thrower, Sara, Farr, S. Michelle, Panther, Lindsey, Gomez, Emilda, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Mandefro, Berhan, Trost, Hannah, Pinedo, Louis, Banuelos, Maria G., Liu, Chunyan, Moran, Ruby, Garcia, Veronica, Workman, Michael, Ho, Richie, Wyman, Stacia, Roggenbuck, Jennifer, Harms, Matthew B., Stocksdale, Jennifer, Miramontes, Ricardo, Wang, Keona, Venkatraman, Vidya, Holewenski, Ronald, Sundararaman, Niveda, Pandey, Rakhi, Manalo, Danica-Mae, Donde, Aneesh, Huynh, Nhan, Adam, Miriam, Wassie, Brook T., Vertudes, Edward, Amirani, Naufa, Raja, Krishna, Thomas, Reuben, Hayes, Lindsey, Lenail, Alex, Cerezo, Aianna, Luppino, Sarah, Farrar, Alanna, Pothier, Lindsay, Prina, Carolyn, Morgan, Todd, Jamil, Arish, Heintzman, Sarah, Jockel-Balsarotti, Jennifer, Karanja, Elizabeth, Markway, Jesse, McCallum, Molly, Joslin, Ben, Alibazoglu, Deniz, Kolb, Stephen, Ajroud-Driss, Senda, Baloh, Robert, Heitzman, Daragh, Miller, Tim, Glass, Jonathan D., Patel-Murray, Natasha Leanna, Yu, Hong, Sinani, Ervin, Vigneswaran, Prasha, Sherman, Alexander V., Ahmad, Omar, Roy, Promit, Beavers, Jay C., Zeiler, Steven, Krakauer, John W., Agurto, Carla, Cecchi, Guillermo, Bellard, Mary, Raghav, Yogindra, Sachs, Karen, Ehrenberger, Tobias, Bruce, Elizabeth, Cudkowicz, Merit E., Maragakis, Nicholas, Norel, Raquel, Van Eyk, Jennifer E., Finkbeiner, Steven, Berry, James, Sareen, Dhruv, Thompson, Leslie M., Fraenkel, Ernest, Svendsen, Clive N., Rothstein, Jeffrey D.

“…Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and…”
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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice by Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, Alice L, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Mónica, Díaz-Barriga, A Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Kedaigle, Amanda J, Gipson, Theresa A, Yildirim, Ferah, Ng, Christopher W, Milani, Pamela, Housman, David E, Fraenkel, Ernest, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N

“…The Huntington's disease (HD) induced pluripotent stem cell (iPSC) consortium describe the combined use of differentiated patient-derived iPSCs and systems…”
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Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes by Mattis, Virginia B, Svendsen, Soshana P, Ebert, Allison, Svendsen, Clive N, King, Alvin R, Casale, Malcolm, Winokur, Sara T, Batugedara, Gayani, Vawter, Marquis, Donovan, Peter J, Lock, Leslie F, Thompson, Leslie M, Zhu, Yu, Fossale, Elisa, Singh Atwal, Ranjit, Gillis, Tammy, Mysore, Jayalakshmi, Li, Jian-hong, Seong, IhnSik, Shen, Yiping, Chen, Xiaoli, Wheeler, Vanessa C, MacDonald, Marcy E, Gusella, James F, Akimov, Sergey, Arbez, Nicolas, Juopperi, Tarja, Ratovitski, Tamara, Chiang, Jason H, Kim, Woon Roung, Chighladze, Eka, Watkin, Erin, Zhong, Chun, Makri, Georgia, Cole, Robert N, Margolis, Russell L, Song, Hongjun, Ming, Guoli, Ross, Christopher A, Kaye, Julia A, Daub, Aaron, Sharma, Punita, Mason, Amanda R, Finkbeiner, Steven, Yu, Junying, Thomson, James A, Rushton, David, Brazier, Stephen P, Battersby, Alysia A, Redfern, Amanda, Tseng, Hsui-Er, Harrison, Alexander W, Kemp, Paul J, Allen, Nicholas D, Onorati, Marco, Castiglioni, Valentina, Cattaneo, Elena, Arjomand, Jamshid

“…Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded stretch of CAG trinucleotide repeats that results in neuronal…”
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Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls by Tsitkov, Stanislav, Valentine, Kelsey, Kozareva, Velina, Donde, Aneesh, Frank, Aaron, Lei, Susan, E. Van Eyk, Jennifer, Finkbeiner, Steve, Rothstein, Jeffrey D., Thompson, Leslie M., Sareen, Dhruv, Svendsen, Clive N., Fraenkel, Ernest

“…Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only a small fraction of cases explained by…”
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An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients by Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert H., Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Li, Jonathan, Lim, Ryan G., Kaye, Julia A., Dardov, Victoria, Coyne, Alyssa N., Wu, Jie, Milani, Pamela, Cheng, Andrew, Thompson, Terri G., Ornelas, Loren, Frank, Aaron, Adam, Miriam, Banuelos, Maria G., Casale, Malcolm, Cox, Veerle, Escalante-Chong, Renan, Daigle, J. Gavin, Gomez, Emilda, Hayes, Lindsey, Holewenski, Ronald, Lei, Susan, Lenail, Alex, Lima, Leandro, Mandefro, Berhan, Matlock, Andrea, Panther, Lindsay, Patel-Murray, Natasha Leanna, Pham, Jacqueline, Ramamoorthy, Divya, Sachs, Karen, Shelley, Brandon, Stocksdale, Jennifer, Trost, Hannah, Wilhelm, Mark, Venkatraman, Vidya, Wassie, Brook T., Wyman, Stacia, Yang, Stephanie, Van Eyk, Jennifer E., Lloyd, Thomas E., Finkbeiner, Steven, Fraenkel, Ernest, Rothstein, Jeffrey D., Sareen, Dhruv, Svendsen, Clive N., Thompson, Leslie M.

“…Neurodegenerative diseases are challenging for systems biology because of the lack of reliable animal models or patient samples at early disease stages…”
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A 3′UTR Pumilio-Binding Element Directs Translational Activation in Olfactory Sensory Neurons by Kaye, Julia A., Rose, Natalie C., Goldsworthy, Brett, Goga, Andrei, L'Etoile, Noelle D.

“…Prolonged stimulation leads to specific and stable changes in an animal's behavior. In interneurons, this plasticity requires spatial and temporal control of…”
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A Three-groups Non-local Model for Combining Heterogeneous Data Sources to Identify Genes Associated with Parkinson's Disease by Wixson, Troy P, Shaby, Benjamin A, Philtron, Daisy L, Consortium, International Parkinson Disease Genomics, Lima, Leandro A, Wyman, Stacia K, Kaye, Julia A, Finkbeiner, Steven

“…We seek to identify genes involved in Parkinson's Disease (PD) by combining information across different experiment types. Each experiment, taken individually,…”
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