Association between the body mass index and the risk of Barrett's esophagus in Japan

We investigated the association between long-segment Barrett's esophagus and obesity in the Japanese population in a multicenter case-control trial. One hundred thirteen patients with endoscopically detected Barrett's esophagus with a length of more than 2 cm and the same number of sex- an...

Full description

Saved in:

Bibliographic Details
Published in:	Digestion Vol. 90; no. 1; p. 1
Main Authors:	Shinkai, Hirohiko, Iijima, Katsunori, Koike, Tomoyuki, Abe, Yasuhiko, Dairaku, Naohiro, Inomata, Yoshifumi, Kayaba, Syoichi, Ishiyama, Fumitake, Oikawa, Tomoyuki, Ohyauchi, Motoki, Ito, Hirotaka, Asonuma, Sho, Hoshi, Tatsuya, Kato, Katsuaki, Ohara, Shuichi, Shimosegawa, Tooru
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-2014
Subjects:	Barrett Esophagus - epidemiology Barrett Esophagus - ethnology Barrett Esophagus - etiology Body Mass Index Case-Control Studies Cross-Sectional Studies Female Gastroesophageal Reflux - complications Humans Japan Male Middle Aged Obesity - complications Risk Factors Japan
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We investigated the association between long-segment Barrett's esophagus and obesity in the Japanese population in a multicenter case-control trial. One hundred thirteen patients with endoscopically detected Barrett's esophagus with a length of more than 2 cm and the same number of sex- and age-matched controls were prospectively enrolled. Barrett's esophagus was diagnosed based on the Prague C and M criteria. The body mass index (BMI) of the subjects was categorized into the following groups: normal, BMI <22.9; overweight, BMI 23.0-24.9, and obese, BMI >25.0. To determine the association between BMI and the risk of Barrett's esophagus, multivariate logistic regression analyses were performed. The basically adjusted regression model adjusted for smoking and alcohol consumption revealed that overweight and obesity were significantly associated with an elevated risk of Barrett's esophagus (OR 2.4, 95% CI 1.2-4.7, and OR 2.5, 95% CI 1.3-4.6, respectively). The intensity of the association was not attenuated even after adjustment for gastroesophageal reflux disease-related parameters. An increased BMI was associated with an increased risk for Barrett's esophagus through a gastroesophageal reflux-independent mechanism in the Japanese population. Further, unlike in Caucasian populations, being even slightly overweight with a BMI of 23.0-24.9 was an independent risk factor in the Japanese population.
ISSN:	1421-9867
DOI:	10.1159/000357776