Search Results - "Kay, Richard G"

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery by Larraufie, Pierre, Roberts, Geoffrey P., McGavigan, Anne K., Kay, Richard G., Li, Joyce, Leiter, Andrew, Melvin, Audrey, Biggs, Emma K., Ravn, Peter, Davy, Kathleen, Hornigold, David C., Yeo, Giles S.H., Hardwick, Richard H., Reimann, Frank, Gribble, Fiona M.

“…Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial…”
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Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling by Roberts, Geoffrey P, Larraufie, Pierre, Richards, Paul, Kay, Richard G, Galvin, Sam G, Miedzybrodzka, Emily L, Leiter, Andrew, Li, H Joyce, Glass, Leslie L, Ma, Marcella K L, Lam, Brian, Yeo, Giles S H, Scharfmann, Raphaël, Chiarugi, Davide, Hardwick, Richard H, Reimann, Frank, Gribble, Fiona M

“…Enteroendocrine cells (EECs) produce hormones such as glucagon-like peptide 1 and peptide YY that regulate food absorption, insulin secretion, and appetite…”
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Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture by Goldspink, Deborah A., Lu, Van B., Miedzybrodzka, Emily L., Smith, Christopher A., Foreman, Rachel E., Billing, Lawrence J., Kay, Richard G., Reimann, Frank, Gribble, Fiona M.

“…Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs…”
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Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells by Billing, Lawrence J., Larraufie, Pierre, Lewis, Jo, Leiter, Andrew, Li, Joyce, Lam, Brian, Yeo, Giles SH, Goldspink, Deborah A., Kay, Richard G., Gribble, Fiona M., Reimann, Frank

“…Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial…”
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Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine by Glass, Leslie L., Calero-Nieto, Fernando J., Jawaid, Wajid, Larraufie, Pierre, Kay, Richard G., Göttgens, Berthold, Reimann, Frank, Gribble, Fiona M.

“…To identify sub-populations of intestinal preproglucagon-expressing (PPG) cells producing Glucagon-like Peptide-1, and their associated expression profiles of…”
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Identification of Structural and Molecular Signatures Mediating Adaptive Changes in the Mouse Kidney in Response to Pregnancy by Lopez-Tello, Jorge, Jimenez-Martinez, Maria Angeles, Salazar-Petres, Esteban, Patel, Ritik, George, Amy L, Kay, Richard G, Sferruzzi-Perri, Amanda N

“…Pregnancy is characterized by adaptations in the function of several maternal body systems that ensure the development of the fetus whilst maintaining health…”
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Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells by Billing, Lawrence J., Smith, Christopher A., Larraufie, Pierre, Goldspink, Deborah A., Galvin, Sam, Kay, Richard G., Howe, Jonathan D., Walker, Ryan, Pruna, Mihai, Glass, Leslie, Pais, Ramona, Gribble, Fiona M., Reimann, Frank

“…Insulin-like peptide-5 (INSL5) is an orexigenic gut hormone found in a subset of colonic and rectal enteroendocrine L-cells together with the anorexigenic…”
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Motilin fluctuations in healthy volunteers determined by liquid chromatography mass spectrometry by Foreman, Rachel E, Bannon, Christopher A, Kay, Richard G, Reimann, Frank, Gribble, Fiona M

“…Motilin is a hormone secreted by specialised enteroendocrine cells in the small intestine, and is known to modulate gastrointestinal motility in humans,…”
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The application of ultra-performance liquid chromatography/tandem mass spectrometry to the detection and quantitation of apolipoproteins in human serum by Kay, Richard G., Gregory, Barbara, Grace, Philip B., Pleasance, Steve

“…The detection and quantitation of apolipoproteins, important markers for coronary heart disease, in serum by liquid chromatography/tandem mass spectrometry…”
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Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids by Miedzybrodzka, Emily L., Foreman, Rachel E., Lu, Van B., George, Amy L., Smith, Christopher A., Larraufie, Pierre, Kay, Richard G., Goldspink, Deborah A., Reimann, Frank, Gribble, Fiona M.

“…Motilin is a proximal small intestinal hormone with roles in gastrointestinal motility, gallbladder emptying, and hunger initiation. In vivo motilin release is…”
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MRMaid, the Web-based Tool for Designing Multiple Reaction Monitoring (MRM) Transitions by Mead, Jennifer A., Bianco, Luca, Ottone, Vanessa, Barton, Chris, Kay, Richard G., Lilley, Kathryn S., Bond, Nicholas J., Bessant, Conrad

“…Multiple reaction monitoring (MRM) of peptides uses tandem mass spectrometry to quantify selected proteins of interest, such as those previously identified in…”
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Placental secretome characterization identifies candidates for pregnancy complications by Napso, Tina, Zhao, Xiaohui, Lligoña, Marta Ibañez, Sandovici, Ionel, Kay, Richard G., George, Amy L., Gribble, Fiona M., Reimann, Frank, Meek, Claire L., Hamilton, Russell S., Sferruzzi-Perri, Amanda N.

“…Alterations in maternal physiological adaptation during pregnancy lead to complications, including abnormal birthweight and gestational diabetes. Maternal…”
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Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis by Kirwan, Peter, Kay, Richard G., Brouwers, Bas, Herranz-Pérez, Vicente, Jura, Magdalena, Larraufie, Pierre, Jerber, Julie, Pembroke, Jason, Bartels, Theresa, White, Anne, Gribble, Fiona M., Reimann, Frank, Farooqi, I. Sadaf, O'Rahilly, Stephen, Merkle, Florian T.

“…The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable…”
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Organoid Sample Preparation and Extraction for LC-MS Peptidomics by Miedzybrodzka, Emily L., Foreman, Rachel E., Galvin, Sam G., Larraufie, Pierre, George, Amy L., Goldspink, Deborah A., Reimann, Frank, Gribble, Fiona M., Kay, Richard G.

“…This protocol describes the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass…”
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Peptidomics: A Review of Clinical Applications and Methodologies by Foreman, Rachel E, George, Amy L, Reimann, Frank, Gribble, Fiona M, Kay, Richard G

“…Improvements in both liquid chromatography (LC) and mass spectrometry (MS) instrumentation have greatly enhanced proteomic and small molecule metabolomic…”
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Selective stimulation of colonic L cells improves metabolic outcomes in mice by Lewis, Jo E., Miedzybrodzka, Emily L., Foreman, Rachel E., Woodward, Orla R. M., Kay, Richard G., Goldspink, Deborah A., Gribble, Fiona M., Reimann, Frank

“…Aims/hypothesis Insulin-like peptide-5 (INSL5) is found only in distal colonic L cells, which co-express glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)…”
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Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery by Roberts, Geoffrey P., Kay, Richard G., Howard, James, Hardwick, Richard H., Reimann, Frank, Gribble, Fiona M.

“…Altered enteroendocrine hormone responses are widely believed to underlie the beneficial effects of bariatric surgery in type 2 diabetes. While elevated…”
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LC-MS/MS based detection of circulating proinsulin derived peptides in patients with altered pancreatic beta cell function by Foreman, Rachel E., Meek, Claire L., Roberts, Geoffrey P., George, Amy L., Reimann, Frank, Gribble, Fiona M., Kay, Richard G

“…•Single extraction and analysis for multiple proinsulin derived peptides in plasma.•Clear differentiation of proinsulin, des-31,32 proinsulin, insulin and…”
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Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets by Ajjaji, Dalila, Ben M'barek, Kalthoum, Mimmack, Michael L, England, Cheryl, Herscovitz, Haya, Dong, Liang, Kay, Richard G, Patel, Satish, Saudek, Vladimir, Small, Donald M, Savage, David B, Thiam, Abdou Rachid

“…Lipid droplets (LDs) in all eukaryotic cells are coated with at least one of the perilipin (Plin) family of proteins. They all regulate key intracellular…”
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Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids by Guccio, Nunzio, Alcaino, Constanza, Miedzybrodzka, Emily L, Santos-Hernández, Marta, Smith, Christopher A, Davison, Adam, Bany Bakar, Rula, Kay, Richard G, Reimann, Frank, Gribble, Fiona M

“…Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by enteroendocrine K cells in the proximal small intestine. This study aimed…”
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