Search Results - "Kay, Gemma L."

The pathophysiology of bile acid diarrhoea: differences in the colonic microbiome, metabolome and bile acids by Sagar, Nidhi M., Duboc, Henri, Kay, Gemma L., Alam, Mohammad T., Wicaksono, Alfian N., Covington, James A., Quince, Christopher, Kokkorou, Margarita, Svolos, Vaios, Palmieri, Lola J., Gerasimidis, Konstantinos, Walters, Julian R. F., Arasaradnam, Ramesh P.

“…Bile acid diarrhoea (BAD) is a common disorder resulting from increased loss of bile acids (BAs), overlapping irritable bowel syndrome with diarrhoea (IBS-D)…”
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Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection by Charalampous, Themoula, Kay, Gemma L., Richardson, Hollian, Aydin, Alp, Baldan, Rossella, Jeanes, Christopher, Rae, Duncan, Grundy, Sara, Turner, Daniel J., Wain, John, Leggett, Richard M., Livermore, David M., O’Grady, Justin

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Development and proof-of-concept demonstration of a clinical metagenomics method for the rapid detection of bloodstream infection by Moragues-Solanas, Lluis, Le-Viet, Thanh, McSorley, Elinor, Halford, Carl, Lockhart, Daniel S, Aydin, Alp, Kay, Gemma L, Elumogo, Ngozi, Mullen, William, O'Grady, Justin, Gilmour, Matthew W

“…The timely and accurate diagnosis of bloodstream infection (BSI) is critical for patient management. With longstanding challenges for routine blood culture,…”
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Whole-genome sequencing illuminates the evolution and spread of multidrug-resistant tuberculosis in Southwest Nigeria by Senghore, Madikay, Otu, Jacob, Witney, Adam, Gehre, Florian, Doughty, Emma L, Kay, Gemma L, Butcher, Phillip, Salako, Kayode, Kehinde, Aderemi, Onyejepu, Nneka, Idigbe, Emmanuel, Corrah, Tumani, de Jong, Bouke, Pallen, Mark J, Antonio, Martin

“…Nigeria has an emerging problem with multidrug-resistant tuberculosis (MDR-TB). Whole-genome sequencing was used to understand the epidemiology of tuberculosis…”
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Recovery of a medieval Brucella melitensis genome using shotgun metagenomics by Kay, Gemma L, Sergeant, Martin J, Giuffra, Valentina, Bandiera, Pasquale, Milanese, Marco, Bramanti, Barbara, Bianucci, Raffaella, Pallen, Mark J

“…Shotgun metagenomics provides a powerful assumption-free approach to the recovery of pathogen genomes from contemporary and historical material. We sequenced…”
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Whole-Genome Sequencing of Brachyspira hyodysenteriae Isolates From England and Wales Reveals Similarities to European Isolates and Mutations Associated With Reduced Sensitivity to Antimicrobials by Stubberfield, Emma, Sheldon, Jonathan, Card, Roderick M., AbuOun, Manal, Rogers, Jon, Williamson, Susanna, Kay, Gemma L., Pallen, Mark J., Anjum, Muna F.

“…Brachyspira hyodysenteriae is the principal cause of swine dysentery, a disease that threatens economic productivity of pigs in many countries as it can spread…”
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Hybrid metagenome assemblies link carbohydrate structure with function in the human gut microbiome by Ravi, Anuradha, Troncoso-Rey, Perla, Ahn-Jarvis, Jennifer, Corbin, Kendall R., Harris, Suzanne, Harris, Hannah, Aydin, Alp, Kay, Gemma L., Le Viet, Thanh, Gilroy, Rachel, Pallen, Mark J., Page, Andrew J., O’Grady, Justin, Warren, Frederick J.

“…Complex carbohydrates that escape small intestinal digestion, are broken down in the large intestine by enzymes encoded by the gut microbiome. This is a…”
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Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection by Charalampous, Themoula, Kay, Gemma L., Richardson, Hollian, Aydin, Alp, Baldan, Rossella, Jeanes, Christopher, Rae, Duncan, Grundy, Sara, Turner, Daniel J., Wain, John, Leggett, Richard M., Livermore, David M., O’Grady, Justin

“…The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is culture, which has poor sensitivity and is too slow to guide…”
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Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe by Kay, Gemma L., Sergeant, Martin J., Zhou, Zhemin, Chan, Jacqueline Z.-M., Millard, Andrew, Quick, Joshua, Szikossy, Ildikó, Pap, Ildikó, Spigelman, Mark, Loman, Nicholas J., Achtman, Mark, Donoghue, Helen D., Pallen, Mark J.

“…Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB’ relate to what we see today. Here…”
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Determination and quantification of microbial communities and antimicrobial resistance on food through host DNA-depleted metagenomics by Bloomfield, Samuel J., Zomer, Aldert L., O'Grady, Justin, Kay, Gemma L., Wain, John, Janecko, Nicol, Palau, Raphaëlle, Mather, Alison E.

“…Food products carry bacteria unless specifically sterilised. These bacteria can be pathogenic, commensal or associated with food spoilage, and may also be…”
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CoronaHiT: high-throughput sequencing of SARS-CoV-2 genomes by Baker, Dave J, Aydin, Alp, Le-Viet, Thanh, Kay, Gemma L, Rudder, Steven, de Oliveira Martins, Leonardo, Tedim, Ana P, Kolyva, Anastasia, Diaz, Maria, Alikhan, Nabil-Fareed, Meadows, Lizzie, Bell, Andrew, Gutierrez, Ana Victoria, Trotter, Alexander J, Thomson, Nicholas M, Gilroy, Rachel, Griffith, Luke, Adriaenssens, Evelien M, Stanley, Rachael, Charles, Ian G, Elumogo, Ngozi, Wain, John, Prakash, Reenesh, Meader, Emma, Mather, Alison E, Webber, Mark A, Dervisevic, Samir, Page, Andrew J, O'Grady, Justin

“…We present CoronaHiT, a platform and throughput flexible method for sequencing SARS-CoV-2 genomes (≤ 96 on MinION or > 96 on Illumina NextSeq) depending on…”
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Identification and characterisation of enteroaggregative Escherichia coli subtypes associated with human disease by Ellis, Samuel J., Crossman, Lisa C., McGrath, Conor J., Chattaway, Marie A., Hölken, Johanna M., Brett, Bernard, Bundy, Leah, Kay, Gemma L., Wain, John, Schüller, Stephanie

“…Enteroaggregative E. coli (EAEC) are a major cause of diarrhoea worldwide. Due to their heterogeneity and carriage in healthy individuals, identification of…”
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Ceftriaxone-resistant Salmonella Typhi carries an IncI1-ST31 plasmid encoding CTX-M-15 by Djeghout, Bilal, Saha, Senjuti, Sajib, Mohammad Saiful Islam, Tanmoy, Arif Mohammad, Islam, Maksuda, Kay, Gemma L, Langridge, Gemma C, Endtz, Hubert P, Wain, John, Saha, Samir K

“…Ceftriaxone is the drug of choice for typhoid fever and the emergence of resistant Salmonella Typhi raises major concerns for treatment. There are an…”
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Evolution of Mycobacterium tuberculosis complex lineages and their role in an emerging threat of multidrug resistant tuberculosis in Bamako, Mali by Senghore, Madikay, Diarra, Bassirou, Gehre, Florian, Otu, Jacob, Worwui, Archibald, Muhammad, Abdul Khalie, Kwambana-Adams, Brenda, Kay, Gemma L., Sanogo, Moumine, Baya, Bocar, Orsega, Susan, Doumbia, Seydou, Diallo, Souleymane, de Jong, Bouke C., Pallen, Mark J., Antonio, Martin

“…In recent years Bamako has been faced with an emerging threat from multidrug resistant TB (MDR-TB). Whole genome sequence analysis was performed on a subset of…”
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Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways by Simpson, Daniel H, Hapeshi, Alexia, Rogers, Nicola J, Brabec, Viktor, Clarkson, Guy J, Fox, David J, Hrabina, Ondrej, Kay, Gemma L, King, Andrew K, Malina, Jaroslav, Millard, Andrew D, Moat, John, Roper, David I, Song, Hualong, Waterfield, Nicholas R, Scott, Peter

“…A range of new water-compatible optically pure metallohelices - made by self-assembly of simple non-peptidic organic components around Fe ions - exhibit…”
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Bioencapsulation and Colonization Characteristics of Lactococcus lactis subsp. lactis CF4MRS in Artemia franciscana: a Biological Approach for the Control of Edwardsiellosis in Larviculture by Loh, Jiun Yan, Kay, Gemma L., Ting, Adeline Su Yien

“…Predominance of beneficial bacteria helps to establish a healthy microbiota in fish gastrointestinal system and thus to reduce emerging pathogen. In this…”
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Metagenomics and microscope revealed T. trichiura and other intestinal parasites in a cesspit of an Italian nineteenth century aristocratic palace by Chessa, Daniela, Murgia, Manuela, Sias, Emanuela, Deligios, Massimo, Mazzarello, Vittorio, Fiamma, Maura, Rovina, Daniela, Carenti, Gabriele, Ganau, Giulia, Pintore, Elisabetta, Fiori, Mauro, Kay, Gemma L., Ponzeletti, Alessandro, Cappuccinelli, Piero, Kelvin, David J., Wain, John, Rubino, Salvatore

“…This study evidenced the presence of parasites in a cesspit of an aristocratic palace of nineteenth century in Sardinia (Italy) by the use of classical…”
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An inter-laboratory study to investigate the impact of the bioinformatics component on microbiome analysis using mock communities by O’Sullivan, Denise M., Doyle, Ronan M., Temisak, Sasithon, Redshaw, Nicholas, Whale, Alexandra S., Logan, Grace, Huang, Jiabin, Fischer, Nicole, Amos, Gregory C. A., Preston, Mark D., Marchesi, Julian R., Wagner, Josef, Parkhill, Julian, Motro, Yair, Denise, Hubert, Finn, Robert D., Harris, Kathryn A., Kay, Gemma L., O’Grady, Justin, Ransom-Jones, Emma, Wu, Huihai, Laing, Emma, Studholme, David J., Benavente, Ernest Diez, Phelan, Jody, Clark, Taane G., Moran-Gilad, Jacob, Huggett, Jim F.

“…Despite the advent of whole genome metagenomics, targeted approaches (such as 16S rRNA gene amplicon sequencing) continue to be valuable for determining the…”
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Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups by Hurst, Rachel, Meader, Emma, Gihawi, Abraham, Rallapalli, Ghanasyam, Clark, Jeremy, Kay, Gemma L., Webb, Martyn, Manley, Kate, Curley, Helen, Walker, Helen, Kumar, Ravi, Schmidt, Katarzyna, Crossman, Lisa, Eeles, Rosalind A., Wedge, David C., Lynch, Andy G., Massie, Charlie E., Yazbek-Hanna, Marcelino, Rochester, Mark, Mills, Robert D., Mithen, Richard F., Traka, Maria H., Ball, Richard Y., O'Grady, Justin, Brewer, Daniel S., Wain, John, Cooper, Colin S.

“…Considerably improved characterisation of the urine and prostate microbiomes are provided, including the identification of four novel bacteria. These…”
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Forensic Analysis Reveals Acute Decompensation of Chronic Heart Failure in a 3500‐Year‐Old Egyptian Dignitary by Bianucci, Raffaella, Loynes, Robert D., Sutherland, M. Linda, Lallo, Rudy, Kay, Gemma L., Froesch, Philippe, Pallen, Mark J., Charlier, Philippe, Nerlich, Andreas G.

“…Naturally preserved and embalmed bodies from archeological contexts represent a powerful source of information for forensic investigators. They allow one to…”
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