Search Results - "Kawauchi, Daisuke"

Epigenetic regulation in medulloblastoma pathogenesis revealed by genetically engineered mouse models by Shiraishi, Ryo, Kawauchi, Daisuke

“…Medulloblastoma is the most common malignant cerebellar tumor in children. Recent technological advances in multilayered ’omics data analysis have revealed 4…”
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Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis by Szulzewsky, Frank, Arora, Sonali, Hoellerbauer, Pia, King, Claire, Nathan, Erica, Chan, Marina, Cimino, Patrick J, Ozawa, Tatsuya, Kawauchi, Daisuke, Pajtler, Kristian W, Gilbertson, Richard J, Paddison, Patrick J, Vasioukhin, Valeri, Gujral, Taranjit S, Holland, Eric C

“…YAP1 is a transcriptional coactivator and the principal effector of the Hippo signaling pathway, which is causally implicated in human cancer. Several gene…”
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Editorial: Molecular characteristics and personalized treatment for pediatric brain tumors by Feng, Weijun, Kawauchi, Daisuke, Wan, Feng

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TNF Counterbalances the Emergence of M2 Tumor Macrophages by Kratochvill, Franz, Neale, Geoffrey, Haverkamp, Jessica M., Van de Velde, Lee-Ann, Smith, Amber M., Kawauchi, Daisuke, McEvoy, Justina, Roussel, Martine F., Dyer, Michael A., Qualls, Joseph E., Murray, Peter J.

“…Cancer can involve non-resolving, persistent inflammation where varying numbers of tumor-associated macrophages (TAMs) infiltrate and adopt different…”
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A Mouse Model of the Most Aggressive Subgroup of Human Medulloblastoma by Kawauchi, Daisuke, Robinson, Giles, Uziel, Tamar, Gibson, Paul, Rehg, Jerold, Gao, Cuilan, Finkelstein, David, Qu, Chunxu, Pounds, Stanley, Ellison, David W., Gilbertson, Richard J., Roussel, Martine F.

“…Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis…”
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Eribulin prolongs survival in an orthotopic xenograft mouse model of malignant meningioma by Nakano, Tomoyuki, Fujimoto, Kenji, Tomiyama, Arata, Takahashi, Masamichi, Achiha, Takamune, Arita, Hideyuki, Kawauchi, Daisuke, Yasukawa, Mami, Masutomi, Kenkichi, Kondo, Akihide, Narita, Yoshitaka, Maehara, Taketoshi, Ichimura, Koichi

“…Meningioma is the most common intracranial tumor, with generally favorable patient prognosis. However, patients with malignant meningioma typically experience…”
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YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis by Pajtler, Kristian W., Wei, Yiju, Okonechnikov, Konstantin, Silva, Patricia B. G., Vouri, Mikaella, Zhang, Lei, Brabetz, Sebastian, Sieber, Laura, Gulley, Melissa, Mauermann, Monika, Wedig, Tatjana, Mack, Norman, Imamura Kawasawa, Yuka, Sharma, Tanvi, Zuckermann, Marc, Andreiuolo, Felipe, Holland, Eric, Maass, Kendra, Körkel-Qu, Huiqin, Liu, Hai-Kun, Sahm, Felix, Capper, David, Bunt, Jens, Richards, Linda J., Jones, David T. W., Korshunov, Andrey, Chavez, Lukas, Lichter, Peter, Hoshino, Mikio, Pfister, Stefan M., Kool, Marcel, Li, Wei, Kawauchi, Daisuke

“…YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show…”
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The ALK inhibitors, alectinib and ceritinib, induce ALK‐independent and STAT3‐dependent glioblastoma cell death by Kawauchi, Daisuke, Takahashi, Masamichi, Satomi, Kaishi, Yamamuro, Shun, Kobayashi, Tatsuya, Uchida, Eita, Honda‐Kitahara, Mai, Narita, Yoshitaka, Iwadate, Yasuo, Ichimura, Koichi, Tomiyama, Arata

“…Glioblastoma (GBM) is the most common, but extremely malignant, brain tumor; thus, the development of novel therapeutic strategies for GBMs is imperative. Many…”
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Primary cilia control translation and the cell cycle in medulloblastoma by Youn, Yong Ha, Hou, Shirui, Wu, Chang-Chih, Kawauchi, Daisuke, Orr, Brent A, Robinson, Giles W, Finkelstein, David, Taketo, Makoto M, Gilbertson, Richard J, Roussel, Martine F, Han, Young-Goo

“…The primary cilium, a signaling organelle projecting from the surface of a cell, controls cellular physiology and behavior. The presence or absence of primary…”
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Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme by Feng, Weijun, Kawauchi, Daisuke, Körkel-Qu, Huiqin, Deng, Huan, Serger, Elisabeth, Sieber, Laura, Lieberman, Jenna Ariel, Jimeno-González, Silvia, Lambo, Sander, Hanna, Bola S., Harim, Yassin, Jansen, Malin, Neuerburg, Anna, Friesen, Olga, Zuckermann, Marc, Rajendran, Vijayanad, Gronych, Jan, Ayrault, Olivier, Korshunov, Andrey, Jones, David T. W., Kool, Marcel, Northcott, Paul A., Lichter, Peter, Cortés-Ledesma, Felipe, Pfister, Stefan M., Liu, Hai-Kun

“…Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase…”
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Lomustine and nimustine exert efficient antitumor effects against glioblastoma models with acquired temozolomide resistance by Yamamuro, Shun, Takahashi, Masamichi, Satomi, Kaishi, Sasaki, Nobuyoshi, Kobayashi, Tatsuya, Uchida, Eita, Kawauchi, Daisuke, Nakano, Tomoyuki, Fujii, Takashi, Narita, Yoshitaka, Kondo, Akihide, Wada, Kojiro, Yoshino, Atsuo, Ichimura, Koichi, Tomiyama, Arata

“…Glioblastomas (GBM) often acquire resistance against temozolomide (TMZ) after continuous treatment and recur as TMZ‐resistant GBM (TMZ‐R‐GBM). Lomustine (CCNU)…”
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Sonic Hedgehog Signaling in Cerebellar Development and Cancer by Wang, Wanchen, Shiraishi, Ryo, Kawauchi, Daisuke

“…The sonic hedgehog (SHH) pathway regulates the development of the central nervous system in vertebrates. Aberrant regulation of SHH signaling pathways often…”
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ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma by Arabzade, Amir, Zhao, Yanhua, Varadharajan, Srinidhi, Chen, Hsiao-Chi, Jessa, Selin, Rivas, Bryan, Stuckert, Austin J, Solis, Minerva, Kardian, Alisha, Tlais, Dana, Golbourn, Brian J, Stanton, Ann-Catherine J, Chan, Yuen San, Olson, Calla, Karlin, Kristen L, Kong, Kathleen, Kupp, Robert, Hu, Baoli, Injac, Sarah G, Ngo, Madeline, Wang, Peter R, De León, Luz A, Sahm, Felix, Kawauchi, Daisuke, Pfister, Stefan M, Lin, Charles Y, Hodges, H Courtney, Singh, Irtisha, Westbrook, Thomas F, Chintagumpala, Murali M, Blaney, Susan M, Parsons, Donald W, Pajtler, Kristian W, Agnihotri, Sameer, Gilbertson, Richard J, Yi, Joanna, Jabado, Nada, Kleinman, Claudia L, Bertrand, Kelsey C, Deneen, Benjamin, Mack, Stephen C

“…More than 60% of supratentorial ependymomas harbor a (ZR ) gene fusion (formerly ). To study the biology of ZR , we developed an autochthonous mouse tumor…”
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The clinical characteristics and outcomes of incidentally discovered glioblastoma by Kawauchi, Daisuke, Ohno, Makoto, Honda-Kitahara, Mai, Miyakita, Yasuji, Takahashi, Masamichi, Yanagisawa, Shunsuke, Tamura, Yukie, Kikuchi, Miyu, Ichimura, Koichi, Narita, Yoshitaka

“…Objective With an increase in the number of imaging examinations and the development of imaging technology, a small number of glioblastomas (GBMs) are…”
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MGMT gene promoter methylation by pyrosequencing method correlates volumetric response and neurological status in IDH wild-type glioblastomas by Hosoya, Tomohiro, Takahashi, Masamichi, Honda-Kitahara, Mai, Miyakita, Yasuji, Ohno, Makoto, Yanagisawa, Shunsuke, Omura, Takaki, Kawauchi, Daisuke, Tamura, Yukie, Kikuchi, Miyu, Nakano, Tomoyuki, Yoshida, Akihiko, Igaki, Hiroshi, Matsushita, Yuko, Ichimura, Koichi, Narita, Yoshitaka

“…Purpose Although the usefulness of O 6 -methylguanine DNA methyltransferase (MGMT) promoter methylation analysis for predicting response to chemoradiotherapy…”
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Author Correction: Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage by Ghasemi, David R., Okonechnikov, Konstantin, Rademacher, Anne, Tirier, Stephan, Maass, Kendra K., Schumacher, Hanna, Joshi, Piyush, Gold, Maxwell P., Sundheimer, Julia, Statz, Britta, Rifaioglu, Ahmet S., Bauer, Katharina, Schumacher, Sabrina, Bortolomeazzi, Michele, Giangaspero, Felice, Ernst, Kati J., Clifford, Steven C., Saez-Rodriguez, Julio, Jones, David T. W., Kawauchi, Daisuke, Fraenkel, Ernest, Mallm, Jan-Philipp, Rippe, Karsten, Korshunov, Andrey, Pfister, Stefan M., Pajtler, Kristian W.

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Clinical characteristics and prognosis of Glioblastoma patients with infratentorial recurrence by Kawauchi, Daisuke, Ohno, Makoto, Honda-Kitahara, Mai, Miyakita, Yasuji, Takahashi, Masamichi, Yanagisawa, Shunsuke, Tamura, Yukie, Kikuchi, Miyu, Ichimura, Koichi, Narita, Yoshitaka

“…Glioblastoma (GBM) infrequently recurs in the infratentorial region. Such Infratentorial recurrence (ITR) has some clinically unique characteristics, such as…”
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Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons by Kobayashi, Hiroaki, Saragai, Shunsuke, Naito, Atsushi, Ichio, Koji, Kawauchi, Daisuke, Murakami, Fujio

“…The calcium ion regulates many aspects of neuronal migration, which is an indispensable process in the development of the nervous system. Calmodulin (CaM) is a…”
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Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage by Ghasemi, David R., Okonechnikov, Konstantin, Rademacher, Anne, Tirier, Stephan, Maass, Kendra K., Schumacher, Hanna, Joshi, Piyush, Gold, Maxwell P., Sundheimer, Julia, Statz, Britta, Rifaioglu, Ahmet S., Bauer, Katharina, Schumacher, Sabrina, Bortolomeazzi, Michele, Giangaspero, Felice, Ernst, Kati J., Clifford, Steven C., Saez-Rodriguez, Julio, Jones, David T. W., Kawauchi, Daisuke, Fraenkel, Ernest, Mallm, Jan-Philipp, Rippe, Karsten, Korshunov, Andrey, Pfister, Stefan M., Pajtler, Kristian W.

“…Medulloblastomas with extensive nodularity are cerebellar tumors characterized by two distinct compartments and variable disease progression. The mechanisms…”
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Ligand Installation to Polymeric Micelles for Pediatric Brain Tumor Targeting by Watanabe, Takayoshi, Mizuno, Hayato Laurence, Norimatsu, Jumpei, Obara, Takumi, Cabral, Horacio, Tsumoto, Kouhei, Nakakido, Makoto, Kawauchi, Daisuke, Anraku, Yasutaka

“…Medulloblastoma is a life-threatening disease with poor therapeutic outcomes. In chemotherapy, low drug accumulation has been a cause of these outcomes. Such…”
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