Search Results - "Kawasumi, Aiko"
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Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2
Published in Science (American Association for the Advancement of Science) (12-10-2012)“…Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is…”
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Transcriptional regulators in the Hippo signaling pathway control organ growth in Xenopus tadpole tail regeneration
Published in Developmental biology (01-12-2014)“…The size and shape of tissues are tightly controlled by synchronized processes among cells and tissues to produce an integrated organ. The Hippo signaling…”
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Appendage‐restricted gene induction using a heated agarose gel for studying regeneration in metamorphosed Xenopus laevis and Pleurodeles waltl
Published in Development, growth & differentiation (01-02-2023)“…Amphibians and fish often regenerate lost parts of their appendages (tail, limb, and fin) after amputation. Limb regeneration in adult amphibians provides an…”
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Wound healing in mammals and amphibians: toward limb regeneration in mammals
Published in Current topics in microbiology and immunology (01-01-2013)“…Mammalian fetal skin regenerates perfectly, but adult skin repairs by the formation of scar tissue. The cause of this imperfect repair by adult skin is not…”
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Two rotating cilia in the node cavity are sufficient to break left–right symmetry in the mouse embryo
Published in Nature communications (10-01-2012)“…Determination of left–right asymmetry in mouse embryos is achieved by a leftward fluid flow (nodal flow) in the node cavity that is generated by clockwise…”
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Cells from subcutaneous tissues contribute to scarless skin regeneration in Xenopus laevis froglets
Published in Developmental dynamics (01-08-2017)“…Background: Mammals cannot regenerate the dermis and other skin structures after an injury and instead form a scar. However, a Xenopus laevis froglet can…”
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An archetype and scaling of developmental tissue dynamics across species
Published in Nature communications (11-12-2023)“…Morphometric studies have revealed the existence of simple geometric relationships among various animal shapes. However, we have little knowledge of the…”
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hoxc12/c13 as key regulators for rebooting the developmental program in Xenopus limb regeneration
Published in Nature communications (22-04-2024)“…During organ regeneration, after the initial responses to injury, gene expression patterns similar to those in normal development are reestablished during…”
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Application of local gene induction by infrared laser‐mediated microscope and temperature stimulator to amphibian regeneration study
Published in Development, growth & differentiation (01-12-2015)“…Urodele amphibians (newts and salamanders) and anuran amphibians (frogs) are excellent research models to reveal mechanisms of three‐dimensional organ…”
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Morphometric staging of organ development based on cross sectional images
Published in Journal of theoretical biology (07-03-2018)“…•An objective staging of developing organs is essential in systems biological studies.•We propose a novel method for staging based on cross sectional…”
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Fluid flow and interlinked feedback loops establish left–right asymmetric decay of Cerl2 mRNA
Published in Nature communications (27-12-2012)Get full text
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Epigenetic modification maintains intrinsic limb-cell identity in Xenopus limb bud regeneration
Published in Developmental biology (15-10-2015)“…Many amphibians can regenerate limbs, even in adulthood. If a limb is amputated, the stump generates a blastema that makes a complete, new limb in a process…”
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Left–right asymmetry in the level of active Nodal protein produced in the node is translated into left–right asymmetry in the lateral plate of mouse embryos
Published in Developmental biology (15-05-2011)“…Left–right (L–R) asymmetry in the mouse embryo is generated in the node and is dependent on cilia-driven fluid flow, but how the initial asymmetry is…”
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Fluid flow and interlinked feedback loops establish left–right asymmetric decay of Cerl2 mRNA
Published in Nature communications (01-12-2012)“…Breaking of left–right symmetry in mouse embryos requires fluid flow at the node, but the precise action of the flow has remained unknown. Here we show that…”
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Quantitative and comparative analysis of tissue deformation dynamics for chick and Xenopus limb morphogenesis
Published in Mechanisms of development (01-07-2017)Get full text
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SKIP modifies gene expression by affecting both transcription and splicing
Published in Biochemical and biophysical research communications (02-04-2004)“…SKIP has been described as a transcriptional coregulator as well as a spliceosome component, but the relationship between these functions is not clear. We…”
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11-P007 Mechanisms of left–right asymmetric signal generation around the node
Published in Mechanisms of development (01-08-2009)Get full text
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