Search Results - "Kawashima, Yusuke"

Optimization of Data-Independent Acquisition Mass Spectrometry for Deep and Highly Sensitive Proteomic Analysis by Kawashima, Yusuke, Watanabe, Eiichiro, Umeyama, Taichi, Nakajima, Daisuke, Hattori, Masahira, Honda, Kenya, Ohara, Osamu

“…Data-independent acquisition (DIA)-mass spectrometry (MS)-based proteomic analysis overtop the existing data-dependent acquisition (DDA)-MS-based proteomic…”
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Toward proteome‐wide exploration of proteins in dried blood spots using liquid chromatography‐coupled mass spectrometry by Nakajima, Daisuke, Ohara, Osamu, Kawashima, Yusuke

“…Dried blood spot (DBS) sampling is a method with advantages over conventional blood sampling in relation to collection, cost, storage, and transportation. Such…”
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Cysteinyl leukotriene metabolism of human eosinophils in allergic disease by Miyata, Jun, Fukunaga, Koichi, Kawashima, Yusuke, Ohara, Osamu, Arita, Makoto

“…Eosinophils are multifaceted immune cells with diverse functions that enhance allergic inflammation. Cysteinyl leukotrienes (cys-LTs), mainly synthesized in…”
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Development of a Simple and Stable NanoESI Spray System Using Suction Wind from the MS Inlet by Kawashima, Yusuke, Ishikawa, Masaki, Konno, Ryo, Nakajima, Daisuke, Ohara, Osamu

“…Improving the reproducibility of proteome analysis systems presents a challenge; therefore, in this study, we developed a new insertion spray ionization…”
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Data-Independent Acquisition Mass Spectrometry-Based Deep Proteome Analysis for Hydrophobic Proteins from Dried Blood Spots Enriched by Sodium Carbonate Precipitation by Nakajima, Daisuke, Ohara, Osamu, Kawashima, Yusuke

“…Dried blood spots (DBS) are widely used for screening molecular profiles, including enzymatic activity. However, hydrophilic proteins present in large amounts…”
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Difference Between HPV-Positive and HPV-Negative Non-Oropharyngeal Head and Neck Cancer: Texture Analysis Features on CT by Fujita, Akifumi, Buch, Karen, Li, Baojun, Kawashima, Yusuke, Qureshi, Muhammad M, Sakai, Osamu

“…To identify the specific texture parameter that shows significant differences between human papillomavirus (HPV)-positive (HPV) and HPV-negative (HPV)…”
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Generation of orthotopically functional salivary gland from embryonic stem cells by Tanaka, Junichi, Ogawa, Miho, Hojo, Hironori, Kawashima, Yusuke, Mabuchi, Yo, Hata, Kenji, Nakamura, Shiro, Yasuhara, Rika, Takamatsu, Koki, Irié, Tarou, Fukada, Toshiyuki, Sakai, Takayoshi, Inoue, Tomio, Nishimura, Riko, Ohara, Osamu, Saito, Ichiro, Ohba, Shinsuke, Tsuji, Takashi, Mishima, Kenji

“…Organoids generated from pluripotent stem cells are used in the development of organ replacement regenerative therapy by recapitulating the process of…”
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TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia by Ochiiwa, Hiroaki, Ailiken, Guzhanuer, Yokoyama, Masataka, Yamagata, Kazuyuki, Nagano, Hidekazu, Yoshimura, Chihoko, Muraoka, Hiromi, Ishida, Keiji, Haruma, Tomonori, Nakayama, Akitoshi, Hashimoto, Naoko, Murata, Kazutaka, Nishimura, Motoi, Kawashima, Yusuke, Ohara, Osamu, Ohkubo, Shuichi, Tanaka, Tomoaki

“…TAS4464, a potent, selective small molecule NEDD8-activating enzyme (NAE) inhibitor, leads to inactivation of cullin-RING E3 ubiquitin ligases (CRLs) and…”
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Materials chemistry of triplet dynamic nuclear polarization by Nishimura, Koki, Kouno, Hironori, Kawashima, Yusuke, Orihashi, Kana, Fujiwara, Saiya, Tateishi, Kenichiro, Uesaka, Tomohiro, Kimizuka, Nobuo, Yanai, Nobuhiro

“…Dynamic nuclear polarization with photo-excited triplet electrons (triplet-DNP) has the potential to enhance the sensitivity of nuclear magnetic resonance…”
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Mdm2 requires Sprouty4 to regulate focal adhesion formation and metastasis independent of p53 by de Queiroz, Rafaela Muniz, Efe, Gizem, Guzman, Asja, Hashimoto, Naoko, Kawashima, Yusuke, Tanaka, Tomoaki, Rustgi, Anil K., Prives, Carol

“…Although the E3 ligase Mdm2 and its homologue and binding partner MdmX are the major regulators of the p53 tumor suppressor protein, it is now evident that…”
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Proteome Analysis of Serum Purified Using Solanum tuberosum and Lycopersicon esculentum Lectins by Nakajima, Daisuke, Konno, Ryo, Miyashita, Yasuomi, Ishikawa, Masaki, Ohara, Osamu, Kawashima, Yusuke

“…Serum and plasma exhibit a broad dynamic range of protein concentrations, posing challenges for proteome analysis. Various technologies have been developed to…”
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A highly efficient method for extracting peptides from a single mouse hypothalamus by Nakagawa, Yuzuru, Matsui, Takashi, Konno, Ryo, Kawashima, Yusuke, Sato, Toshiya, Itakura, Makoto, Kodera, Yoshio

“…Living organisms contain a variety of endogenous peptides that function as significant regulators of many biological processes. Endogenous peptides are…”
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Suprabasin-derived bioactive peptides identified by plasma peptidomics by Taguchi, Tomomi, Kodera, Yoshio, Oba, Kazuhito, Saito, Tatsuya, Nakagawa, Yuzuru, Kawashima, Yusuke, Shichiri, Masayoshi

“…Identification of low-abundance, low-molecular-weight native peptides using non-tryptic plasma has long remained an unmet challenge, leaving potential…”
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Porphyrins as Versatile, Aggregation-Tolerant, and Biocompatible Polarizing Agents for Triplet Dynamic Nuclear Polarization of Biomolecules by Hamachi, Tomoyuki, Nishimura, Koki, Kouno, Hironori, Kawashima, Yusuke, Tateishi, Kenichiro, Uesaka, Tomohiro, Kimizuka, Nobuo, Yanai, Nobuhiro

“…Triplet dynamic nuclear polarization (triplet-DNP) achieves nuclear spin polarization at moderate temperatures by using spin polarization of photoexcited…”
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Using texture analysis of head CT images to differentiate osteoporosis from normal bone density by Kawashima, Yusuke, Fujita, Akifumi, Buch, Karen, Li, Baojun, Qureshi, Muhammad M., Chapman, Margaret N., Sakai, Osamu

“…•Several texture features demonstrated differences between normal BMD and osteoporosis on head CT.•‘Median’ may be the strongest feature for discriminating…”
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Bile proteome analysis by high‐precision mass spectrometry to examine novel biomarkers of primary sclerosing cholangitis by Kan, Motoyasu, Chiba, Tetsuhiro, Konno, Ryo, Kouchi, Yusuke, Mishima, Takashi, Kawashima, Yusuke, Kishimoto, Takashi, Ohtsuka, Masayuki, Ohara, Osamu, Kato, Naoya

“…Background Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of unknown etiology that affects the intra‐ and extrahepatic bile ducts. The…”
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A Simple Method for In-Depth Proteome Analysis of Mammalian Cell Culture Conditioned Media Containing Fetal Bovine Serum by Nakamura, Ren, Nakajima, Daisuke, Sato, Hironori, Endo, Yusuke, Ohara, Osamu, Kawashima, Yusuke

“…A conditioned medium of a cell culture is widely used for various biological applications and frequently analyzed to characterize the functional proteins…”
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Epsin-mediated degradation of IP3R1 fuels atherosclerosis by Dong, Yunzhou, Lee, Yang, Cui, Kui, He, Ming, Wang, Beibei, Bhattacharjee, Sudarshan, Zhu, Bo, Yago, Tadayuki, Zhang, Kun, Deng, Lin, Ouyang, Kunfu, Wen, Aiyun, Cowan, Douglas B., Song, Kai, Yu, Lili, Brophy, Megan L., Liu, Xiaolei, Wylie-Sears, Jill, Wu, Hao, Wong, Scott, Cui, Guanglin, Kawashima, Yusuke, Matsumoto, Hiroyuki, Kodera, Yoshio, Wojcikiewicz, Richard J. H., Srivastava, Sanjay, Bischoff, Joyce, Wang, Da-Zhi, Ley, Klaus, Chen, Hong

“…The epsin family of endocytic adapter proteins are widely expressed, and interact with both proteins and lipids to regulate a variety of cell functions…”
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Identification of trypsin-degrading commensals in the large intestine by Li, Youxian, Watanabe, Eiichiro, Kawashima, Yusuke, Plichta, Damian R., Wang, Zhujun, Ujike, Makoto, Ang, Qi Yan, Wu, Runrun, Furuichi, Munehiro, Takeshita, Kozue, Yoshida, Koji, Nishiyama, Keita, Kearney, Sean M., Suda, Wataru, Hattori, Masahira, Sasajima, Satoshi, Matsunaga, Takahiro, Zhang, Xiaoxi, Watanabe, Kazuto, Fujishiro, Jun, Norman, Jason M., Olle, Bernat, Matsuyama, Shutoku, Namkoong, Ho, Uwamino, Yoshifumi, Ishii, Makoto, Fukunaga, Koichi, Hasegawa, Naoki, Ohara, Osamu, Xavier, Ramnik J., Atarashi, Koji, Honda, Kenya

“…Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in intestinal pathological conditions 1 – 3 . However, the players…”
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Simple and Sensitive Analysis for Dried Blood Spot Proteins by Sodium Carbonate Precipitation for Clinical Proteomics by Nakajima, Daisuke, Kawashima, Yusuke, Shibata, Hirofumi, Yasumi, Takahiro, Isa, Masahiko, Izawa, Kazushi, Nishikomori, Ryuta, Heike, Toshio, Ohara, Osamu

“…Dried blood spots (DBS) are widely used for screening biomolecular profiles, including enzymatic activities. However, detection of minor proteins in DBS by…”
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