Search Results - "Kawase, Reiko"
-
1
Using zebrafish in systems toxicology for developmental toxicity testing
Published in Congenital anomalies (01-01-2016)“…With the high cost and the long‐term assessment of developmental toxicity testing in mammals, the vertebrate zebrafish has become a useful alternative model…”
Get full text
Journal Article -
2
Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy
Published in Frontiers in pharmacology (14-06-2016)“…Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and is associated with a number of potential outcomes, including impaired…”
Get full text
Journal Article -
3
Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish
Published in Frontiers in pharmacology (11-07-2016)“…Oligodendrocytes are major myelin-producing cells and play essential roles in the function of a healthy nervous system. However, they are also one of the most…”
Get full text
Journal Article -
4
Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers
Published in Frontiers in pharmacology (03-11-2015)“…Sleep-wake states are impaired in various neurological disorders. Impairment of sleep-wake states can be an early condition that exacerbates these disorders…”
Get full text
Journal Article -
5
In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish
Published in ACS chemical biology (19-02-2016)“…Mitochondrial dysfunction has been implicated in various drug-induced toxicities and genetic disorders. Recently, the zebrafish has emerged as a versatile…”
Get full text
Journal Article -
6
E2F4 Promotes Neuronal Regeneration and Functional Recovery after Spinal Cord Injury in Zebrafish
Published in Frontiers in pharmacology (09-05-2016)“…Mammals exhibit poor recovery after spinal cord injury (SCI), whereas non-mammalian vertebrates exhibit significant spontaneous recovery after SCI. The…”
Get full text
Journal Article -
7
EP300 Protects from Light-Induced Retinopathy in Zebrafish
Published in Frontiers in pharmacology (19-05-2016)“…Exposure of rhodopsin to bright white light can induce photoreceptor cell damage and degeneration. However, a comprehensive understanding of the mechanisms…”
Get full text
Journal Article -
8
Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension
Published in Frontiers in pharmacology (07-06-2016)“…Pulmonary arterial hypertension (PAH) is a heterogeneous disorder associated with a progressive increase in pulmonary artery resistance and pressure. Although…”
Get full text
Journal Article -
9
Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity
Published in Frontiers in pharmacology (15-09-2015)“…Both caloric restriction (CR) and resveratrol (RSV) have beneficial effects on obesity. However, the biochemical pathways that mediate these beneficial effects…”
Get full text
Journal Article -
10
Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulate Myelination in Zebrafish
Published in Frontiers in pharmacology (01-07-2016)“…Oligodendrocytes are major myelin-producing cells and play essential roles in the function of a healthy nervous system. However, they are also one of the most…”
Get full text
Journal Article -
11
DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina
Published in Frontiers in pharmacology (14-03-2016)“…Intestinal helminths cause iron-deficiency anemia in pregnant women, associated with premature delivery, low birth weight, maternal ill health, and maternal…”
Get full text
Journal Article