Search Results - "Kawano, Daniel"

Carrageenans: Biological properties, chemical modifications and structural analysis – A review by Campo, Vanessa Leiria, Kawano, Daniel Fábio, Silva, Dílson Braz da, Carvalho, Ivone

“…Carrageenans are sulphated linear polysaccharides of d-galactose and 3,6-anhydro- d-galactose extracted from certain red seaweeds of the Rhodophyceae class…”
Get full text

Organometallic–Erlotinib Conjugates Active against Lung Cancer Cells and as Emerging Virus Entry Inhibitors by Biegański, Przemysław, Gazecka, Monika, Nowak, Rafał, Gorski, Aleksander, Dutkiewicz, Natalia, Kawano, Daniel Fábio, Zmora, Paweł, Kowalski, Konrad

“…Conjugation of organometallic entities to drug molecules is a strategy that often results in products with new biological activity profiles compared to those…”
Get full text

Structural basis for the design of allosteric inhibitors of the Aurora kinase A enzyme in the cancer chemotherapy by de Souza, Valéria Barbosa, Kawano, Daniel Fábio

“…Aurora kinases are essential enzymes for the control of cell cycle. The specific role of aurora kinase A (AURKA) is the regulation of spindle assembly and…”
Get full text

New insights into the chemistry and antioxidant activity of coumarins by Torres, Fernando Cidade, Brucker, Natália, Andrade, Saulo Fernandes, Kawano, Daniel Fabio, Garcia, Solange Cristina, Poser, Gilsane Lino von, Eifler-Lima, Vera Lucia

“…Coumarins are considered to be privileged structures due to their broad range of biological properties, including anticoagulant, anti-neurodegenerative,…”
Get more information

Click ferrocenyl-erlotinib conjugates active against erlotinib-resistant non-small cell lung cancer cells in vitro by Biegański, Przemysław, Godel, Martina, Riganti, Chiara, Kawano, Daniel Fábio, Kopecka, Joanna, Kowalski, Konrad

“…[Display omitted] •New ferrocenyl-erlotynib derivatives were obtained with CuAAC and RuAAC reaction.•Compound 3 and 6 showed better than erlotinib anticancer…”
Get full text

The Enantiomeric Discrimination of 5-Hexyl-2-methyl-3,4-dihydro-2H-pyrrole by Sulfobutyl ether-β-cyclodextrin: A Case Study by Kawano, Daniel, Costa, Bruna, Romero-Orejón, Katherine, Loureiro, Hugo, de Jesus, Dosil, Marsaioli, Anita

“…1-Pyrrolines are important intermediates of active natural products, such as the 2,5-dialkyl-1-pyrroline derivatives found in fire ant venoms. Here,…”
Get full text

Entering the Sugar Rush Era: Revisiting the Antihyperglycemic Activities of Biguanides after a Century of Metformin Discovery by de Oliveira Neto, Xisto Antonio, Barssotti, Leticia, Fiori-Duarte, Ana Thereza, de Lima Barbosa, Helena Cristina, Kawano, Daniel Fábio

“…The development of clinically viable metformin analogs is a challenge largely to be overcome. Despite being an extremely efficient drug for the treatment of…”
Get more information

Modulation of Pseudomonas aeruginosa quorum sensing by ajoene through direct competition with small RNAs for binding at the proximal site of Hfq – A structure-based perspective by Thereza Fiori-Duarte, Ana, Bitencourt de Souza Ferreira, Luciana, Sanches Ascencio, Amanda, Fábio Kawano, Daniel

“…•Gram-negative bacteria use RNA chaperones to match small regulatory RNAs (sRNAs) with messenger RNAs for the expression of their virulence factor.•Ajoene was…”
Get full text

The decoupling of second-order linear systems with a singular mass matrix by Kawano, Daniel T., Morzfeld, Matthias, Ma, Fai

“…It was demonstrated in earlier work that a nondefective, linear dynamical system with an invertible mass matrix in free or forced motion may be decoupled in…”
Get full text

Rayleigh’s quotients and eigenvalue bounds for linear dynamical systems by Salsa, Rubens G., Kawano, Daniel T., Ma, Fai

“…The primary objective of this article is to demonstrate that Rayleigh’s quotient and its variants retain the usual properties of boundedness and stationarity…”
Get full text

Imidazoles and benzimidazoles as tubulin-modulators for anti-cancer therapy by Torres, Fernando C, García-Rubiño, M Eugenia, Lozano-López, César, Kawano, Daniel F, Eifler-Lima, Vera L, von Poser, Gilsane L, Campos, Joaquín M

“…Imidazoles and benzimidazoles are privileged heterocyclic bioactive compounds used with success in the clinical practice of innumerous diseases. Although there…”
Get more information

Decoupling of second-order linear systems by isospectral transformation by Kawano, Daniel T., Salsa, Rubens G., Ma, Fai

“…We consider the class of real second-order linear dynamical systems that admit real diagonal forms with the same eigenvalues and partial multiplicities. The…”
Get full text

In silico design and in vitro assessment of anti-Helicobacter pylori compounds as potential small-molecule arginase inhibitors by Fiori-Duarte, Ana Thereza, de Oliveira Guarnieri, João Paulo, de Oliveira Borlot, Jessica Rodrigues Pereira, Lancellotti, Marcelo, Rodrigues, Ricardo Pereira, Kitagawa, Rodrigo Rezende, Kawano, Daniel Fábio

“…Related to a variety of gastrointestinal disorders ranging from gastric ulcer to gastric adenocarcinoma, the infection caused by the gram-negative bacteria…”
Get full text

A canonical form of the equation of motion of linear dynamical systems by Kawano, Daniel T., Salsa, Rubens Goncalves, Ma, Fai, Morzfeld, Matthias

“…The equation of motion of a discrete linear system has the form of a second-order ordinary differential equation with three real and square coefficient…”
Get full text

Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole-quinazolines as antiproliferative agents displaying ERK inhibitory activity by Nunes, Paulo Sérgio Gonçalves, da Silva, Gabriel, Nascimento, Sofia, Mantoani, Susimaire Pedersoli, de Andrade, Peterson, Bernardes, Emerson Soares, Kawano, Daniel Fábio, Leopoldino, Andreia Machado, Carvalho, Ivone

“…[Display omitted] •Twelve ERK1/2 kinase inhibitors have been synthesized using CuAAC reaction.•Derivative 25a induced G0/G1 stalling in BT-20 cells and a…”
Get full text

Targeting Trypanosoma cruzi platelet-activating factor receptors: scope for the development of novel drugs to treat Chagas Disease by Kawano, Daniel Fábio, Carvalho, Ivone

“…Chagas Disease (CD), a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, accounts for the highest burden of parasitic diseases…”
Get more information

Molecular Docking Reveals the Binding Modes of Anticancer Alkylphospholipids and Lysophosphatidylcholine within the Catalytic Domain of Cytidine Triphosphate: Phosphocholine Cytidyltransferase by Neto, Xisto Antonio de Oliveira, Alves, Anna Carolina Schneider, Junior, Reinaldo Antonio Dias, Rodrigues, Ricardo Pereira, Lancellotti, Marcelo, Almeida, Wanda Pereira, Kawano, Daniel Fábio

“…Alkylphospholipids are synthetic analogues of endogenous phosphatidylcholines with a remarkable ability: induce the selective apoptosis of exponentially…”
Get full text

Identification of a novel putative inhibitor of the Plasmodium falciparum purine nucleoside phosphorylase: exploring the purine salvage pathway to design new antimalarial drugs by Kagami, Luciano Porto, das Neves, Gustavo Machado, Rodrigues, Ricardo Pereira, da Silva, Vinicius Barreto, Eifler-Lima, Vera Lucia, Kawano, Daniel Fábio

“…Malaria, a tropical parasitic disease caused by Plasmodium spp., continues to place a heavy social burden, with almost 200 million cases and more than 580,000…”
Get full text

In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained from Boehmeria caudata Sw. Aerial Parts by Paiva, Paula P de, Nunes, Julia H B, Nonato, Fabiana R, Ruiz, Ana L T G, Zafred, Rafael R T, Sousa, Ilza M O, Okubo, Márcia Y, Kawano, Daniel F, Monteiro, Paula A, Foglio, Mary A, Carvalho, João E

“…In the context of the cancer-inflammation relationship and the use of natural products as potential antitumor and anti-inflammatory agents, the…”
Get full text

Using Free Computational Resources To Illustrate the Drug Design Process in an Undergraduate Medicinal Chemistry Course by Rodrigues, Ricardo P, Andrade, Saulo F, Mantoani, Susimaire P, Eifler-Lima, Vera L, Silva, Vinicius B, Kawano, Daniel F

“…Advances in, and dissemination of, computer technologies in the field of drug research now enable the use of molecular modeling tools to teach important…”
Get full text